7B51
Crystal structure of human CRM1 covalently modified by 2-mercaptoethanol at Cys528
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000054 | biological_process | ribosomal subunit export from nucleus |
| A | 0000055 | biological_process | ribosomal large subunit export from nucleus |
| A | 0000056 | biological_process | ribosomal small subunit export from nucleus |
| A | 0000776 | cellular_component | kinetochore |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005049 | molecular_function | nuclear export signal receptor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005635 | cellular_component | nuclear envelope |
| A | 0005642 | cellular_component | annulate lamellae |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006406 | biological_process | mRNA export from nucleus |
| A | 0006611 | biological_process | protein export from nucleus |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0006913 | biological_process | nucleocytoplasmic transport |
| A | 0010824 | biological_process | regulation of centrosome duplication |
| A | 0015030 | cellular_component | Cajal body |
| A | 0015031 | biological_process | protein transport |
| A | 0016020 | cellular_component | membrane |
| A | 0031267 | molecular_function | small GTPase binding |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0032434 | biological_process | regulation of proteasomal ubiquitin-dependent protein catabolic process |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034504 | biological_process | protein localization to nucleus |
| A | 0042176 | biological_process | regulation of protein catabolic process |
| A | 0042254 | biological_process | ribosome biogenesis |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0046825 | biological_process | regulation of protein export from nucleus |
| A | 0051028 | biological_process | mRNA transport |
| A | 1990904 | cellular_component | ribonucleoprotein complex |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0006913 | biological_process | nucleocytoplasmic transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER391 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS446 | |
| A | LYS693 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q80U96 |
| Chain | Residue | Details |
| A | THR448 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q80U96 |
| Chain | Residue | Details |
| A | SER450 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q80U96 |
| Chain | Residue | Details |
| A | TYR454 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1031 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.12, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| B | ALA2 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | THR24 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:31075303 |
| Chain | Residue | Details |
| B | LYS37 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| B | LYS60 | |
| B | LYS99 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| B | LYS71 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:29040603 |
| Chain | Residue | Details |
| B | LYS134 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62827 |
| Chain | Residue | Details |
| B | LYS159 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate |
| Chain | Residue | Details |
| B | LYS71 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS152 |
