Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Y32

Structure of the GTPase heterodimer of human SRP54 and SRalpha

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
A	0008312	molecular_function	7S RNA binding
A	0016887	molecular_function	ATP hydrolysis activity
A	0048500	cellular_component	signal recognition particle
B	0005525	molecular_function	GTP binding
B	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
B	0016887	molecular_function	ATP hydrolysis activity
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
C	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
C	0008312	molecular_function	7S RNA binding
C	0016887	molecular_function	ATP hydrolysis activity
C	0048500	cellular_component	signal recognition particle
D	0005525	molecular_function	GTP binding
D	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
D	0016887	molecular_function	ATP hydrolysis activity
E	0003924	molecular_function	GTPase activity
E	0005525	molecular_function	GTP binding
E	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
E	0008312	molecular_function	7S RNA binding
E	0016887	molecular_function	ATP hydrolysis activity
E	0048500	cellular_component	signal recognition particle
F	0005525	molecular_function	GTP binding
F	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
F	0016887	molecular_function	ATP hydrolysis activity
G	0003924	molecular_function	GTPase activity
G	0005525	molecular_function	GTP binding
G	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
G	0008312	molecular_function	7S RNA binding
G	0016887	molecular_function	ATP hydrolysis activity
G	0048500	cellular_component	signal recognition particle
H	0005525	molecular_function	GTP binding
H	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
H	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	binding site for residue GNP A 301

Chain	Residue
A	GLN110
A	GLN147
A	GLY193
A	LYS249
A	ASP251
A	GLY274
A	THR275
A	GLY276
A	GLU277
A	MG302
A	HOH405
A	GLY111
A	HOH408
A	HOH412
A	HOH418
A	HOH419
A	HOH425
B	ASN427
B	ARG458
B	MET525
B	GNP701
B	HOH802
A	SER112
B	HOH845
A	GLY113
A	LYS114
A	THR115
A	THR116
A	LYS120
A	ARG141

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 302

Chain	Residue
A	THR115
A	GNP301
A	HOH408
A	HOH412
A	HOH418

site_id	AC3
Number of Residues	29
Details	binding site for residue GNP B 701

Chain	Residue
A	GLN110
A	ARG141
A	GNP301
B	ASN427
B	GLY428
B	VAL429
B	GLY430
B	LYS431
B	SER432
B	THR433
B	ASN434
B	LYS437
B	ARG458
B	GLN464
B	GLY523
B	LYS589
B	ASP591
B	GLY615
B	THR616
B	GLY617
B	GLN618
B	MG702
B	HOH813
B	HOH821
B	HOH827
B	HOH831
B	HOH834
B	HOH835
B	HOH845

site_id	AC4
Number of Residues	5
Details	binding site for residue MG B 702

Chain	Residue
B	SER432
B	GNP701
B	HOH813
B	HOH834
B	HOH835

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 B 703

Chain	Residue
B	ARG624
B	SER625
B	HOH820
D	ARG624

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 B 704

Chain	Residue
B	ARG624
D	ARG624
D	SER625

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 B 705

Chain	Residue
B	THR467
B	ARG470
B	HOH852

site_id	AC8
Number of Residues	24
Details	binding site for residue GNP C 301

Chain	Residue
D	ASN427
D	ARG458
D	MET525
D	GNP701
C	GLN110
C	GLY111
C	SER112
C	GLY113
C	LYS114
C	THR115
C	THR116
C	ARG141
C	GLN147
C	GLY193
C	LYS249
C	ASP251
C	GLY274
C	THR275
C	GLY276
C	GLU277
C	MG302
C	HOH403
C	HOH422
C	HOH424

site_id	AC9
Number of Residues	6
Details	binding site for residue MG C 302

Chain	Residue
C	THR115
C	ASP190
C	GNP301
C	HOH413
C	HOH422
C	HOH424

site_id	AD1
Number of Residues	2
Details	binding site for residue SO4 C 303

Chain	Residue
C	LYS47
D	LYS596

site_id	AD2
Number of Residues	26
Details	binding site for residue GNP D 701

Chain	Residue
C	GLN110
C	ARG141
C	GNP301
C	HOH403
D	VAL426
D	ASN427
D	GLY428
D	VAL429
D	GLY430
D	LYS431
D	SER432
D	THR433
D	ASN434
D	LYS437
D	ARG458
D	GLN464
D	GLY523
D	LYS589
D	ASP591
D	GLY615
D	THR616
D	GLY617
D	GLN618
D	MG702
D	HOH826
D	HOH842

site_id	AD3
Number of Residues	5
Details	binding site for residue MG D 702

Chain	Residue
D	SER432
D	GNP701
D	HOH805
D	HOH807
D	HOH826

site_id	AD4
Number of Residues	2
Details	binding site for residue SO4 D 703

Chain	Residue
D	THR467
D	ARG470

site_id	AD5
Number of Residues	29
Details	binding site for residue GNP E 301

Chain	Residue
E	GLN110
E	GLY111
E	SER112
E	GLY113
E	LYS114
E	THR115
E	THR116
E	LYS120
E	ARG141
E	GLN147
E	GLY193
E	LYS249
E	ASP251
E	GLY274
E	THR275
E	GLY276
E	GLU277
E	MG302
E	HOH403
E	HOH406
E	HOH416
E	HOH419
E	HOH421
E	HOH436
E	HOH441
F	ASN427
F	ARG458
F	MET525
F	GNP701

site_id	AD6
Number of Residues	5
Details	binding site for residue MG E 302

Chain	Residue
E	THR115
E	GNP301
E	HOH403
E	HOH416
E	HOH421

site_id	AD7
Number of Residues	22
Details	binding site for residue GNP F 701

Chain	Residue
E	GLN110
E	ARG141
E	GNP301
E	HOH406
F	GLY428
F	VAL429
F	GLY430
F	LYS431
F	SER432
F	THR433
F	ASN434
F	ARG458
F	GLN464
F	GLY523
F	LYS589
F	ASP591
F	GLY615
F	THR616
F	GLY617
F	GLN618
F	MG702
F	HOH810

site_id	AD8
Number of Residues	7
Details	binding site for residue MG F 702

Chain	Residue
F	SER432
F	ARG458
F	ASP520
F	GNP701
F	HOH810
F	HOH811
F	HOH831

site_id	AD9
Number of Residues	2
Details	binding site for residue SO4 F 703

Chain	Residue
F	ARG624
F	SER625

site_id	AE1
Number of Residues	2
Details	binding site for residue SO4 F 704

Chain	Residue
F	ALA576
F	GLN577

site_id	AE2
Number of Residues	2
Details	binding site for residue SO4 F 705

Chain	Residue
F	SER365
F	ASN368

site_id	AE3
Number of Residues	26
Details	binding site for residue GNP G 301

Chain	Residue
G	GLN110
G	GLY111
G	SER112
G	GLY113
G	LYS114
G	THR115
G	THR116
G	LYS120
G	ARG141
G	GLN147
G	GLY193
G	LYS249
G	ASP251
G	GLY274
G	THR275
G	GLY276
G	GLU277
G	MG302
G	HOH404
G	HOH412
G	HOH415
G	HOH419
H	ASN427
H	ARG458
H	MET525
H	GNP701

site_id	AE4
Number of Residues	6
Details	binding site for residue MG G 302

Chain	Residue
G	THR115
G	ASP138
G	ASP190
G	GNP301
G	HOH412
G	HOH415

site_id	AE5
Number of Residues	3
Details	binding site for residue SO4 G 303

Chain	Residue
G	SER162
G	TYR163
G	THR164

site_id	AE6
Number of Residues	28
Details	binding site for residue GNP H 701

Chain	Residue
G	GLN110
G	ARG141
G	GNP301
H	ASN427
H	GLY428
H	VAL429
H	GLY430
H	LYS431
H	SER432
H	THR433
H	ASN434
H	LYS437
H	ARG458
H	GLN464
H	GLY523
H	LYS589
H	ASP591
H	GLY615
H	THR616
H	GLY617
H	GLN618
H	MG702
H	HOH811
H	HOH830
H	HOH832
H	HOH839
H	HOH841
H	HOH843

site_id	AE7
Number of Residues	6
Details	binding site for residue MG H 702

Chain	Residue
H	SER432
H	ARG458
H	GNP701
H	HOH823
H	HOH830
H	HOH839

site_id	AE8
Number of Residues	3
Details	binding site for residue SO4 H 703

Chain	Residue
H	ARG624
H	SER625
H	HOH846

site_id	AE9
Number of Residues	2
Details	binding site for residue SO4 H 704

Chain	Residue
H	THR467
H	ARG470

site_id	AF1
Number of Residues	2
Details	binding site for residue SO4 H 705

Chain	Residue
H	ARG417
H	ARG510

site_id	AF2
Number of Residues	3
Details	binding site for residue SO4 H 706

Chain	Residue
H	LYS496
H	ASP497
H	HOH801

site_id	AF3
Number of Residues	2
Details	binding site for residue SO4 H 707

Chain	Residue
H	ALA576
H	GLN577

Functional Information from PROSITE/UniProt

site_id	PS00300
Number of Residues	14
Details	SRP54 SRP54-type proteins GTP-binding domain signature. PIiFIGTGEhIddF

Chain	Residue	Details
A	PRO269-PHE282
B	PRO610-LEU623

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
B	GLY425
H	GLY425
H	ASP520
H	THR588
B	ASP520
B	THR588
D	GLY425
D	ASP520
D	THR588
F	GLY425
F	ASP520
F	THR588

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
B	SER473
D	SER473
F	SER473
H	SER473

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
B	THR578
D	THR578
F	THR578
H	THR578

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)