6Y23

DDR1 kinase autoinhibited by its juxtamembrane region

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
A	0016020	cellular_component	membrane
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
B	0016020	cellular_component	membrane
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
C	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 A 1001

Chain	Residue
A	PRO593
A	GLY594
A	LYS674
C	PRO593
C	GLY594
C	LYS674

---

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 1002

Chain	Residue
A	ARG755
A	SER899

---

site_id	AC3
Number of Residues	2
Details	binding site for residue SO4 A 1003

Chain	Residue
A	ARG841
A	HIS716

---

site_id	AC4
Number of Residues	2
Details	binding site for residue SO4 A 1004

Chain	Residue
A	ARG755
A	ARG903

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 A 1005

Chain	Residue
A	ARG645
A	LYS646
A	GLY647
B	ASN777

---

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 B 1001

Chain	Residue
B	HIS716
B	ARG841

---

site_id	AC7
Number of Residues	2
Details	binding site for residue SO4 C 1001

Chain	Residue
C	ARG755
C	THR759

---

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 C 1002

Chain	Residue
C	ARG841
C	HOH1101

---

Functional Information from PROSITE/UniProt

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV

Chain	Residue	Details
A	PHE762-VAL774

---

site_id	PS00239
Number of Residues	9
Details	RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. NLYagdYYR

Chain	Residue	Details
A	ASN790-ARG798

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP766
B	ASP766
C	ASP766

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU616
B	LEU616
C	LEU616

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	LYS655
B	LYS655
C	LYS655

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	SER631
B	SER631
C	SER631

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000305|PubMed:16337946

Chain	Residue	Details
A	TYR740
B	TYR740
C	TYR740

---

site_id	SWS_FT_FI6
Number of Residues	9
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:24509848

Chain	Residue	Details
A	TYR792
A	TYR796
A	TYR797
B	TYR792
B	TYR796
B	TYR797
C	TYR792
C	TYR796
C	TYR797

---