6WBN
Cryo-EM structure of human Pannexin 1 channel N255A mutant, gap junction
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0015267 | molecular_function | channel activity |
| A | 0032732 | biological_process | positive regulation of interleukin-1 production |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0015267 | molecular_function | channel activity |
| B | 0032732 | biological_process | positive regulation of interleukin-1 production |
| C | 0006812 | biological_process | monoatomic cation transport |
| C | 0015267 | molecular_function | channel activity |
| C | 0032732 | biological_process | positive regulation of interleukin-1 production |
| D | 0006812 | biological_process | monoatomic cation transport |
| D | 0015267 | molecular_function | channel activity |
| D | 0032732 | biological_process | positive regulation of interleukin-1 production |
| E | 0006812 | biological_process | monoatomic cation transport |
| E | 0015267 | molecular_function | channel activity |
| E | 0032732 | biological_process | positive regulation of interleukin-1 production |
| F | 0006812 | biological_process | monoatomic cation transport |
| F | 0015267 | molecular_function | channel activity |
| F | 0032732 | biological_process | positive regulation of interleukin-1 production |
| G | 0006812 | biological_process | monoatomic cation transport |
| G | 0015267 | molecular_function | channel activity |
| G | 0032732 | biological_process | positive regulation of interleukin-1 production |
| H | 0006812 | biological_process | monoatomic cation transport |
| H | 0015267 | molecular_function | channel activity |
| H | 0032732 | biological_process | positive regulation of interleukin-1 production |
| I | 0006812 | biological_process | monoatomic cation transport |
| I | 0015267 | molecular_function | channel activity |
| I | 0032732 | biological_process | positive regulation of interleukin-1 production |
| J | 0006812 | biological_process | monoatomic cation transport |
| J | 0015267 | molecular_function | channel activity |
| J | 0032732 | biological_process | positive regulation of interleukin-1 production |
| K | 0006812 | biological_process | monoatomic cation transport |
| K | 0015267 | molecular_function | channel activity |
| K | 0032732 | biological_process | positive regulation of interleukin-1 production |
| L | 0006812 | biological_process | monoatomic cation transport |
| L | 0015267 | molecular_function | channel activity |
| L | 0032732 | biological_process | positive regulation of interleukin-1 production |
| M | 0006812 | biological_process | monoatomic cation transport |
| M | 0015267 | molecular_function | channel activity |
| M | 0032732 | biological_process | positive regulation of interleukin-1 production |
| N | 0006812 | biological_process | monoatomic cation transport |
| N | 0015267 | molecular_function | channel activity |
| N | 0032732 | biological_process | positive regulation of interleukin-1 production |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue PTY A 401 |
| Chain | Residue |
| A | GLY99 |
| A | ASN100 |
| A | LEU101 |
| A | TRP104 |
| A | CLR405 |
| B | ILE279 |
| B | PTY402 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue PTY A 402 |
| Chain | Residue |
| A | SER239 |
| A | GLN274 |
| A | LEU275 |
| G | PTY401 |
| A | PHE235 |
| A | LEU237 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue 3PE A 403 |
| Chain | Residue |
| A | MET37 |
| A | TYR293 |
| A | ARG300 |
| A | GLU336 |
| G | PHE126 |
| G | LEU219 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue DGA A 404 |
| Chain | Residue |
| A | TYR10 |
| A | LEU17 |
| A | MET37 |
| A | ILE41 |
| G | LEU125 |
| G | PHE129 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue CLR A 405 |
| Chain | Residue |
| A | TYR230 |
| A | PTY401 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue DGA A 407 |
| Chain | Residue |
| A | LEU125 |
| A | PHE129 |
| B | TYR10 |
| B | LEU17 |
| B | MET37 |
| B | ILE41 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue PTY B 401 |
| Chain | Residue |
| B | GLY99 |
| B | ASN100 |
| B | LEU101 |
| B | TRP104 |
| B | CLR404 |
| C | ILE279 |
| C | PTY402 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue PTY B 402 |
| Chain | Residue |
| A | PTY401 |
| B | PHE235 |
| B | LEU237 |
| B | SER239 |
| B | GLN274 |
| B | LEU275 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue 3PE B 403 |
| Chain | Residue |
| A | PHE126 |
| B | MET37 |
| B | TYR293 |
| B | ARG300 |
| B | GLU336 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue CLR B 404 |
| Chain | Residue |
| B | TYR230 |
| B | PTY401 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue DGA B 406 |
| Chain | Residue |
| B | LEU125 |
| B | PHE129 |
| C | TYR10 |
| C | LEU17 |
| C | MET37 |
| C | ILE41 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue PTY C 401 |
| Chain | Residue |
| C | GLY99 |
| C | ASN100 |
| C | LEU101 |
| C | TRP104 |
| C | CLR404 |
| D | ILE279 |
| D | PTY402 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue PTY C 402 |
| Chain | Residue |
| B | PTY401 |
| C | PHE235 |
| C | LEU237 |
| C | SER239 |
| C | GLN274 |
| C | LEU275 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue 3PE C 403 |
| Chain | Residue |
| B | PHE126 |
| B | LEU219 |
| C | MET37 |
| C | TYR293 |
| C | ARG300 |
| C | GLU336 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue CLR C 404 |
| Chain | Residue |
| C | TYR230 |
| C | PTY401 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue DGA C 406 |
| Chain | Residue |
| C | LEU125 |
| C | PHE129 |
| D | TYR10 |
| D | LEU17 |
| D | MET37 |
| D | ILE41 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue PTY D 401 |
| Chain | Residue |
| D | GLY99 |
| D | ASN100 |
| D | LEU101 |
| D | TRP104 |
| D | CLR404 |
| E | ILE279 |
| E | PTY402 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue PTY D 402 |
| Chain | Residue |
| C | PTY401 |
| D | PHE235 |
| D | LEU237 |
| D | SER239 |
| D | GLN274 |
| D | LEU275 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue 3PE D 403 |
| Chain | Residue |
| C | PHE126 |
| C | LEU219 |
| D | MET37 |
| D | TYR293 |
| D | ARG300 |
| D | GLU336 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue CLR D 404 |
| Chain | Residue |
| D | TYR230 |
| D | PTY401 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue DGA D 406 |
| Chain | Residue |
| D | LEU125 |
| D | PHE129 |
| E | TYR10 |
| E | LEU17 |
| E | MET37 |
| E | ILE41 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue PTY E 401 |
| Chain | Residue |
| E | GLY99 |
| E | ASN100 |
| E | LEU101 |
| E | TRP104 |
| E | CLR404 |
| F | ILE279 |
| F | PTY402 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue PTY E 402 |
| Chain | Residue |
| D | PTY401 |
| E | PHE235 |
| E | LEU237 |
| E | SER239 |
| E | GLN274 |
| E | LEU275 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue 3PE E 403 |
| Chain | Residue |
| D | PHE126 |
| D | LEU219 |
| E | MET37 |
| E | TYR293 |
| E | ARG300 |
| E | GLU336 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue CLR E 404 |
| Chain | Residue |
| E | TYR230 |
| E | PTY401 |
| site_id | AE8 |
| Number of Residues | 6 |
| Details | binding site for residue DGA E 406 |
| Chain | Residue |
| E | LEU125 |
| E | PHE129 |
| F | TYR10 |
| F | LEU17 |
| F | MET37 |
| F | ILE41 |
| site_id | AE9 |
| Number of Residues | 7 |
| Details | binding site for residue PTY F 401 |
| Chain | Residue |
| F | GLY99 |
| F | ASN100 |
| F | LEU101 |
| F | TRP104 |
| F | CLR404 |
| G | ILE279 |
| G | PTY402 |
| site_id | AF1 |
| Number of Residues | 6 |
| Details | binding site for residue PTY F 402 |
| Chain | Residue |
| E | PTY401 |
| F | PHE235 |
| F | LEU237 |
| F | SER239 |
| F | GLN274 |
| F | LEU275 |
| site_id | AF2 |
| Number of Residues | 6 |
| Details | binding site for residue 3PE F 403 |
| Chain | Residue |
| E | PHE126 |
| E | LEU219 |
| F | MET37 |
| F | TYR293 |
| F | ARG300 |
| F | GLU336 |
| site_id | AF3 |
| Number of Residues | 2 |
| Details | binding site for residue CLR F 404 |
| Chain | Residue |
| F | TYR230 |
| F | PTY401 |
| site_id | AF4 |
| Number of Residues | 6 |
| Details | binding site for residue DGA F 406 |
| Chain | Residue |
| F | LEU125 |
| F | PHE129 |
| G | TYR10 |
| G | LEU17 |
| G | MET37 |
| G | ILE41 |
| site_id | AF5 |
| Number of Residues | 8 |
| Details | binding site for residue PTY G 401 |
| Chain | Residue |
| A | LEU52 |
| A | ILE279 |
| A | PTY402 |
| G | GLY99 |
| G | ASN100 |
| G | LEU101 |
| G | TRP104 |
| G | CLR404 |
| site_id | AF6 |
| Number of Residues | 6 |
| Details | binding site for residue PTY G 402 |
| Chain | Residue |
| F | PTY401 |
| G | PHE235 |
| G | LEU237 |
| G | SER239 |
| G | GLN274 |
| G | LEU275 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue 3PE G 403 |
| Chain | Residue |
| F | PHE126 |
| F | LEU219 |
| G | MET37 |
| G | TYR293 |
| G | ARG300 |
| G | GLU336 |
| site_id | AF8 |
| Number of Residues | 2 |
| Details | binding site for residue CLR G 404 |
| Chain | Residue |
| G | TYR230 |
| G | PTY401 |
| site_id | AF9 |
| Number of Residues | 8 |
| Details | binding site for residue PTY H 401 |
| Chain | Residue |
| H | GLY99 |
| H | ASN100 |
| H | LEU101 |
| H | TRP104 |
| H | CLR404 |
| I | LEU52 |
| I | ILE279 |
| I | PTY402 |
| site_id | AG1 |
| Number of Residues | 6 |
| Details | binding site for residue PTY H 402 |
| Chain | Residue |
| H | PHE235 |
| H | LEU237 |
| H | SER239 |
| H | GLN274 |
| H | LEU275 |
| N | PTY402 |
| site_id | AG2 |
| Number of Residues | 6 |
| Details | binding site for residue 3PE H 403 |
| Chain | Residue |
| H | MET37 |
| H | TYR293 |
| H | ARG300 |
| H | GLU336 |
| N | PHE126 |
| N | LEU219 |
| site_id | AG3 |
| Number of Residues | 2 |
| Details | binding site for residue CLR H 404 |
| Chain | Residue |
| H | TYR230 |
| H | PTY401 |
| site_id | AG4 |
| Number of Residues | 6 |
| Details | binding site for residue DGA H 406 |
| Chain | Residue |
| H | LEU125 |
| H | PHE129 |
| I | TYR10 |
| I | LEU17 |
| I | MET37 |
| I | ILE41 |
| site_id | AG5 |
| Number of Residues | 7 |
| Details | binding site for residue PTY I 401 |
| Chain | Residue |
| I | GLY99 |
| I | ASN100 |
| I | LEU101 |
| I | TRP104 |
| I | CLR404 |
| J | ILE279 |
| J | PTY402 |
| site_id | AG6 |
| Number of Residues | 6 |
| Details | binding site for residue PTY I 402 |
| Chain | Residue |
| H | PTY401 |
| I | PHE235 |
| I | LEU237 |
| I | SER239 |
| I | GLN274 |
| I | LEU275 |
| site_id | AG7 |
| Number of Residues | 6 |
| Details | binding site for residue 3PE I 403 |
| Chain | Residue |
| H | PHE126 |
| H | LEU219 |
| I | MET37 |
| I | TYR293 |
| I | ARG300 |
| I | GLU336 |
| site_id | AG8 |
| Number of Residues | 2 |
| Details | binding site for residue CLR I 404 |
| Chain | Residue |
| I | TYR230 |
| I | PTY401 |
| site_id | AG9 |
| Number of Residues | 6 |
| Details | binding site for residue DGA I 406 |
| Chain | Residue |
| I | LEU125 |
| I | PHE129 |
| J | TYR10 |
| J | LEU17 |
| J | MET37 |
| J | ILE41 |
| site_id | AH1 |
| Number of Residues | 7 |
| Details | binding site for residue PTY J 401 |
| Chain | Residue |
| J | GLY99 |
| J | ASN100 |
| J | LEU101 |
| J | TRP104 |
| J | CLR404 |
| K | ILE279 |
| K | PTY402 |
| site_id | AH2 |
| Number of Residues | 6 |
| Details | binding site for residue PTY J 402 |
| Chain | Residue |
| I | PTY401 |
| J | PHE235 |
| J | LEU237 |
| J | SER239 |
| J | GLN274 |
| J | LEU275 |
| site_id | AH3 |
| Number of Residues | 6 |
| Details | binding site for residue 3PE J 403 |
| Chain | Residue |
| I | PHE126 |
| I | LEU219 |
| J | MET37 |
| J | TYR293 |
| J | ARG300 |
| J | GLU336 |
| site_id | AH4 |
| Number of Residues | 2 |
| Details | binding site for residue CLR J 404 |
| Chain | Residue |
| J | TYR230 |
| J | PTY401 |
| site_id | AH5 |
| Number of Residues | 6 |
| Details | binding site for residue DGA J 406 |
| Chain | Residue |
| J | LEU125 |
| J | PHE129 |
| K | TYR10 |
| K | LEU17 |
| K | MET37 |
| K | ILE41 |
| site_id | AH6 |
| Number of Residues | 7 |
| Details | binding site for residue PTY K 401 |
| Chain | Residue |
| K | GLY99 |
| K | ASN100 |
| K | LEU101 |
| K | TRP104 |
| K | CLR404 |
| L | ILE279 |
| L | PTY402 |
| site_id | AH7 |
| Number of Residues | 6 |
| Details | binding site for residue PTY K 402 |
| Chain | Residue |
| J | PTY401 |
| K | PHE235 |
| K | LEU237 |
| K | SER239 |
| K | GLN274 |
| K | LEU275 |
| site_id | AH8 |
| Number of Residues | 6 |
| Details | binding site for residue 3PE K 403 |
| Chain | Residue |
| J | PHE126 |
| J | LEU219 |
| K | MET37 |
| K | TYR293 |
| K | ARG300 |
| K | GLU336 |
| site_id | AH9 |
| Number of Residues | 2 |
| Details | binding site for residue CLR K 404 |
| Chain | Residue |
| K | TYR230 |
| K | PTY401 |
| site_id | AI1 |
| Number of Residues | 6 |
| Details | binding site for residue DGA K 406 |
| Chain | Residue |
| K | LEU125 |
| K | PHE129 |
| L | TYR10 |
| L | LEU17 |
| L | MET37 |
| L | ILE41 |
| site_id | AI2 |
| Number of Residues | 7 |
| Details | binding site for residue PTY L 401 |
| Chain | Residue |
| L | GLY99 |
| L | ASN100 |
| L | LEU101 |
| L | TRP104 |
| L | CLR404 |
| M | ILE279 |
| M | PTY402 |
| site_id | AI3 |
| Number of Residues | 6 |
| Details | binding site for residue PTY L 402 |
| Chain | Residue |
| K | PTY401 |
| L | PHE235 |
| L | LEU237 |
| L | SER239 |
| L | GLN274 |
| L | LEU275 |
| site_id | AI4 |
| Number of Residues | 6 |
| Details | binding site for residue 3PE L 403 |
| Chain | Residue |
| K | PHE126 |
| K | LEU219 |
| L | MET37 |
| L | TYR293 |
| L | ARG300 |
| L | GLU336 |
| site_id | AI5 |
| Number of Residues | 2 |
| Details | binding site for residue CLR L 404 |
| Chain | Residue |
| L | TYR230 |
| L | PTY401 |
| site_id | AI6 |
| Number of Residues | 6 |
| Details | binding site for residue DGA L 406 |
| Chain | Residue |
| L | LEU125 |
| L | PHE129 |
| M | TYR10 |
| M | LEU17 |
| M | MET37 |
| M | ILE41 |
| site_id | AI7 |
| Number of Residues | 7 |
| Details | binding site for residue PTY M 401 |
| Chain | Residue |
| M | GLY99 |
| M | ASN100 |
| M | LEU101 |
| M | TRP104 |
| M | CLR404 |
| N | ILE279 |
| N | PTY403 |
| site_id | AI8 |
| Number of Residues | 6 |
| Details | binding site for residue PTY M 402 |
| Chain | Residue |
| L | PTY401 |
| M | PHE235 |
| M | LEU237 |
| M | SER239 |
| M | GLN274 |
| M | LEU275 |
| site_id | AI9 |
| Number of Residues | 6 |
| Details | binding site for residue 3PE M 403 |
| Chain | Residue |
| L | PHE126 |
| L | LEU219 |
| M | MET37 |
| M | TYR293 |
| M | ARG300 |
| M | GLU336 |
| site_id | AJ1 |
| Number of Residues | 2 |
| Details | binding site for residue CLR M 404 |
| Chain | Residue |
| M | TYR230 |
| M | PTY401 |
| site_id | AJ2 |
| Number of Residues | 6 |
| Details | binding site for residue DGA M 406 |
| Chain | Residue |
| M | LEU125 |
| M | PHE129 |
| N | TYR10 |
| N | LEU17 |
| N | MET37 |
| N | ILE41 |
| site_id | AJ3 |
| Number of Residues | 6 |
| Details | binding site for residue DGA N 401 |
| Chain | Residue |
| H | TYR10 |
| H | LEU17 |
| H | MET37 |
| H | ILE41 |
| N | LEU125 |
| N | PHE129 |
| site_id | AJ4 |
| Number of Residues | 7 |
| Details | binding site for residue PTY N 402 |
| Chain | Residue |
| H | ILE279 |
| H | PTY402 |
| N | GLY99 |
| N | ASN100 |
| N | LEU101 |
| N | TRP104 |
| N | CLR405 |
| site_id | AJ5 |
| Number of Residues | 6 |
| Details | binding site for residue PTY N 403 |
| Chain | Residue |
| M | PTY401 |
| N | PHE235 |
| N | LEU237 |
| N | SER239 |
| N | GLN274 |
| N | LEU275 |
| site_id | AJ6 |
| Number of Residues | 6 |
| Details | binding site for residue 3PE N 404 |
| Chain | Residue |
| M | PHE126 |
| M | LEU219 |
| N | MET37 |
| N | TYR293 |
| N | ARG300 |
| N | GLU336 |
| site_id | AJ7 |
| Number of Residues | 2 |
| Details | binding site for residue CLR N 405 |
| Chain | Residue |
| N | TYR230 |
| N | PTY402 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1120 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00351","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 994 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"Q9JIP4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"30814251","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17715132","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30918116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494015","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33947837","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
