6ULA

Crystal structure of human GAC in complex with inhibitor UPGL00012

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004359	molecular_function	glutaminase activity
A	0006541	biological_process	glutamine metabolic process
B	0004359	molecular_function	glutaminase activity
B	0006541	biological_process	glutamine metabolic process
C	0004359	molecular_function	glutaminase activity
C	0006541	biological_process	glutamine metabolic process
D	0004359	molecular_function	glutaminase activity
D	0006541	biological_process	glutamine metabolic process
E	0004359	molecular_function	glutaminase activity
E	0006541	biological_process	glutamine metabolic process
F	0004359	molecular_function	glutaminase activity
F	0006541	biological_process	glutamine metabolic process
G	0004359	molecular_function	glutaminase activity
G	0006541	biological_process	glutamine metabolic process
H	0004359	molecular_function	glutaminase activity
H	0006541	biological_process	glutamine metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue QA4 A 601

Chain	Residue
A	LYS320
B	ASN324
B	GLU325
B	TYR394
C	ARG317
A	LEU321
A	PHE322
A	LEU323
A	TYR394
B	LYS320
B	LEU321
B	PHE322
B	LEU323

---

site_id	AC2
Number of Residues	14
Details	binding site for residue QA4 C 601

Chain	Residue
C	PHE318
C	LYS320
C	LEU321
C	PHE322
C	LEU323
C	ASN324
C	TYR394
D	LYS320
D	LEU321
D	PHE322
D	LEU323
D	ASN324
D	GLU325
D	TYR394

---

site_id	AC3
Number of Residues	13
Details	binding site for residue QA4 E 602

Chain	Residue
E	LYS320
E	LEU321
E	PHE322
E	LEU323
E	GLU325
E	TYR394
G	LYS320
G	LEU321
G	PHE322
G	LEU323
G	ASN324
G	TYR394
H	ARG317

---

site_id	AC4
Number of Residues	17
Details	binding site for Di-peptide QA4 E 601 and ARG E 317

Chain	Residue
E	GLY315
E	LEU316
E	PHE318
F	LYS320
F	LEU321
F	PHE322
F	LEU323
F	TYR394
H	PHE318
H	LYS320
H	LEU321
H	PHE322
H	LEU323
H	ASN324
H	GLU325
H	ASP327
H	TYR394

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	Region: {"description":"Highly mobile activation loop","evidences":[{"source":"UniProtKB","id":"D3Z7P3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22049910","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22538822","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24451979","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3CZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UNW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VP1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22049910","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22538822","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24451979","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3CZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UNW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VP1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"D3Z7P3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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