Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6UJA

Integrin alpha-v beta-8 in complex with pro-TGF-beta1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001570biological_processvasculogenesis
A0001618molecular_functionvirus receptor activity
A0001704biological_processformation of primary germ layer
A0001846molecular_functionopsonin binding
A0001968molecular_functionfibronectin binding
A0002020molecular_functionprotease binding
A0005080molecular_functionprotein kinase C binding
A0005102molecular_functionsignaling receptor binding
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007229biological_processintegrin-mediated signaling pathway
A0008284biological_processpositive regulation of cell population proliferation
A0008305cellular_componentintegrin complex
A0009888biological_processtissue development
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010745biological_processnegative regulation of macrophage derived foam cell differentiation
A0010888biological_processnegative regulation of lipid storage
A0010989biological_processnegative regulation of low-density lipoprotein particle clearance
A0015026molecular_functioncoreceptor activity
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0017134molecular_functionfibroblast growth factor binding
A0019960molecular_functionC-X3-C chemokine binding
A0030335biological_processpositive regulation of cell migration
A0031258cellular_componentlamellipodium membrane
A0031527cellular_componentfilopodium membrane
A0031528cellular_componentmicrovillus membrane
A0031589biological_processcell-substrate adhesion
A0031994molecular_functioninsulin-like growth factor I binding
A0032369biological_processnegative regulation of lipid transport
A0032587cellular_componentruffle membrane
A0033627biological_processcell adhesion mediated by integrin
A0033690biological_processpositive regulation of osteoblast proliferation
A0034113biological_processheterotypic cell-cell adhesion
A0034446biological_processsubstrate adhesion-dependent cell spreading
A0034682cellular_componentintegrin alphav-beta1 complex
A0034683cellular_componentintegrin alphav-beta3 complex
A0034684cellular_componentintegrin alphav-beta5 complex
A0034685cellular_componentintegrin alphav-beta6 complex
A0034686cellular_componentintegrin alphav-beta8 complex
A0035313biological_processwound healing, spreading of epidermal cells
A0035579cellular_componentspecific granule membrane
A0035866cellular_componentalphav-beta3 integrin-PKCalpha complex
A0035867cellular_componentalphav-beta3 integrin-IGF-1-IGF1R complex
A0035868cellular_componentalphav-beta3 integrin-HMGB1 complex
A0035987biological_processendodermal cell differentiation
A0038023molecular_functionsignaling receptor activity
A0038027biological_processapolipoprotein A-I-mediated signaling pathway
A0038132molecular_functionneuregulin binding
A0043277biological_processapoptotic cell clearance
A0045335cellular_componentphagocytic vesicle
A0045785biological_processpositive regulation of cell adhesion
A0046718biological_processsymbiont entry into host cell
A0046872molecular_functionmetal ion binding
A0050431molecular_functiontransforming growth factor beta binding
A0050748biological_processnegative regulation of lipoprotein metabolic process
A0050764biological_processregulation of phagocytosis
A0050840molecular_functionextracellular matrix binding
A0050919biological_processnegative chemotaxis
A0051057biological_processpositive regulation of small GTPase mediated signal transduction
A0070062cellular_componentextracellular exosome
A0070371biological_processERK1 and ERK2 cascade
A0070588biological_processcalcium ion transmembrane transport
A0071604biological_processtransforming growth factor beta production
A0085017biological_processentry into host cell by a symbiont-containing vacuole
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0098609biological_processcell-cell adhesion
A1902533biological_processpositive regulation of intracellular signal transduction
A1990430molecular_functionextracellular matrix protein binding
A2000536biological_processnegative regulation of entry of bacterium into host cell
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
B0001570biological_processvasculogenesis
B0005178molecular_functionintegrin binding
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0007155biological_processcell adhesion
B0007160biological_processcell-matrix adhesion
B0007166biological_processcell surface receptor signaling pathway
B0007229biological_processintegrin-mediated signaling pathway
B0008305cellular_componentintegrin complex
B0009986cellular_componentcell surface
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0015026molecular_functioncoreceptor activity
B0016477biological_processcell migration
B0030154biological_processcell differentiation
B0033627biological_processcell adhesion mediated by integrin
B0034686cellular_componentintegrin alphav-beta8 complex
B0045766biological_processpositive regulation of angiogenesis
B0046872molecular_functionmetal ion binding
B0051216biological_processcartilage development
B0060674biological_processplacenta blood vessel development
B0070062cellular_componentextracellular exosome
B0098609biological_processcell-cell adhesion
B1990430molecular_functionextracellular matrix protein binding
D0001570biological_processvasculogenesis
D0001657biological_processureteric bud development
D0001837biological_processepithelial to mesenchymal transition
D0001843biological_processneural tube closure
D0002062biological_processchondrocyte differentiation
D0002244biological_processhematopoietic progenitor cell differentiation
D0002460biological_processadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
D0002859biological_processnegative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
D0003179biological_processheart valve morphogenesis
D0003180biological_processaortic valve morphogenesis
D0005114molecular_functiontype II transforming growth factor beta receptor binding
D0005125molecular_functioncytokine activity
D0005160molecular_functiontransforming growth factor beta receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005902cellular_componentmicrovillus
D0006611biological_processprotein export from nucleus
D0006754biological_processATP biosynthetic process
D0006796biological_processphosphate-containing compound metabolic process
D0006954biological_processinflammatory response
D0007179biological_processtransforming growth factor beta receptor signaling pathway
D0007435biological_processsalivary gland morphogenesis
D0007507biological_processheart development
D0008083molecular_functiongrowth factor activity
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0009611biological_processresponse to wounding
D0009986cellular_componentcell surface
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0010718biological_processpositive regulation of epithelial to mesenchymal transition
D0010763biological_processpositive regulation of fibroblast migration
D0010936biological_processnegative regulation of macrophage cytokine production
D0014003biological_processoligodendrocyte development
D0014008biological_processpositive regulation of microglia differentiation
D0016202biological_processregulation of striated muscle tissue development
D0019899molecular_functionenzyme binding
D0021915biological_processneural tube development
D0030154biological_processcell differentiation
D0030214biological_processhyaluronan catabolic process
D0030308biological_processnegative regulation of cell growth
D0030335biological_processpositive regulation of cell migration
D0031012cellular_componentextracellular matrix
D0031293biological_processmembrane protein intracellular domain proteolysis
D0031334biological_processpositive regulation of protein-containing complex assembly
D0032355biological_processresponse to estradiol
D0032570biological_processresponse to progesterone
D0032667biological_processregulation of interleukin-23 production
D0032700biological_processnegative regulation of interleukin-17 production
D0032740biological_processpositive regulation of interleukin-17 production
D0032755biological_processpositive regulation of interleukin-6 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0032801biological_processreceptor catabolic process
D0032930biological_processpositive regulation of superoxide anion generation
D0032967biological_processpositive regulation of collagen biosynthetic process
D0034713molecular_functiontype I transforming growth factor beta receptor binding
D0034714molecular_functiontype III transforming growth factor beta receptor binding
D0042127biological_processregulation of cell population proliferation
D0042306biological_processregulation of protein import into nucleus
D0042307biological_processpositive regulation of protein import into nucleus
D0042802molecular_functionidentical protein binding
D0043117biological_processpositive regulation of vascular permeability
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043410biological_processpositive regulation of MAPK cascade
D0043536biological_processpositive regulation of blood vessel endothelial cell migration
D0043537biological_processnegative regulation of blood vessel endothelial cell migration
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0045066biological_processregulatory T cell differentiation
D0045216biological_processcell-cell junction organization
D0045591biological_processpositive regulation of regulatory T cell differentiation
D0045596biological_processnegative regulation of cell differentiation
D0045599biological_processnegative regulation of fat cell differentiation
D0045662biological_processnegative regulation of myoblast differentiation
D0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
D0045786biological_processnegative regulation of cell cycle
D0045892biological_processnegative regulation of DNA-templated transcription
D0045893biological_processpositive regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0048298biological_processpositive regulation of isotype switching to IgA isotypes
D0048535biological_processlymph node development
D0048642biological_processnegative regulation of skeletal muscle tissue development
D0048661biological_processpositive regulation of smooth muscle cell proliferation
D0050680biological_processnegative regulation of epithelial cell proliferation
D0050714biological_processpositive regulation of protein secretion
D0050729biological_processpositive regulation of inflammatory response
D0050921biological_processpositive regulation of chemotaxis
D0051247biological_processpositive regulation of protein metabolic process
D0051781biological_processpositive regulation of cell division
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0055010biological_processventricular cardiac muscle tissue morphogenesis
D0060325biological_processface morphogenesis
D0060391biological_processpositive regulation of SMAD protein signal transduction
D0070168biological_processnegative regulation of biomineral tissue development
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0070723biological_processresponse to cholesterol
D0071404biological_processcellular response to low-density lipoprotein particle stimulus
D0071456biological_processcellular response to hypoxia
D0071560biological_processcellular response to transforming growth factor beta stimulus
D0071895biological_processodontoblast differentiation
D0072562cellular_componentblood microparticle
D0085029biological_processextracellular matrix assembly
D0090263biological_processpositive regulation of canonical Wnt signaling pathway
D0097191biological_processextrinsic apoptotic signaling pathway
D0098586biological_processcellular response to virus
D1900126biological_processnegative regulation of hyaluronan biosynthetic process
D1900182biological_processpositive regulation of protein localization to nucleus
D1902462biological_processpositive regulation of mesenchymal stem cell proliferation
D1902894biological_processnegative regulation of miRNA transcription
D1902895biological_processpositive regulation of miRNA transcription
D1903077biological_processnegative regulation of protein localization to plasma membrane
D1904018biological_processpositive regulation of vasculature development
D1904894biological_processpositive regulation of receptor signaling pathway via STAT
D1990402biological_processembryonic liver development
D2000048biological_processnegative regulation of cell-cell adhesion mediated by cadherin
D2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
D2000353biological_processpositive regulation of endothelial cell apoptotic process
D2000636biological_processpositive regulation of primary miRNA processing
D2000727biological_processpositive regulation of cardiac muscle cell differentiation
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CqCfsGweGDrC
ChainResidueDetails
BCYS530-CYS541
site_idPS00070
Number of Residues12
DetailsALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. VnSKGQVCSGRG
ChainResidueDetails
BVAL552-GLY563
site_idPS00242
Number of Residues8
DetailsINTEGRIN_ALPHA Integrins alpha chain signature. YRmGFFkR
ChainResidueDetails
ATYR986-ARG993
site_idPS00243
Number of Residues14
DetailsI_EGF_1 Integrins beta chain EGF (I-EGF) domain signature. CsGr..GvCvCgkCsC
ChainResidueDetails
BCYS478-CYS491
BCYS559-CYS572
site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. IhePkgYhanfClGpC
ChainResidueDetails
DILE282-CYS297
site_idPS01186
Number of Residues14
DetailsEGF_2 EGF-like domain signature 2. CqCfsGWegdrcq..C
ChainResidueDetails
BCYS530-CYS543
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues66
DetailsRepeat: {"description":"FG-GAP 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues61
DetailsRepeat: {"description":"FG-GAP 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues52
DetailsRepeat: {"description":"FG-GAP 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues54
DetailsRepeat: {"description":"FG-GAP 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues65
DetailsRepeat: {"description":"FG-GAP 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues57
DetailsRepeat: {"description":"FG-GAP 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues63
DetailsRepeat: {"description":"FG-GAP 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FFG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues238
DetailsDomain: {"description":"VWFA","evidences":[{"source":"PubMed","id":"31792290","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsBinding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"31792290","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OM1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OM2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsBinding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"31792290","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OM2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsBinding site: {"description":"in LIMBS binding site","evidences":[{"source":"PubMed","id":"31792290","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OM1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OM2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"31792290","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OM1","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"31792290","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OM1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OM2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsMotif: {"description":"Cell attachment site","evidences":[{"source":"PubMed","id":"21677751","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21677751","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5VQF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21677751","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

PDB statisticsPDBj update infoContact PDBjnumon