6U9K
MLL1 SET N3861I/Q3867L bound to inhibitor 18 (TC-5153)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 4001 |
| Chain | Residue |
| A | CYS3909 |
| A | CYS3957 |
| A | CYS3959 |
| A | CYS3964 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue Q2V A 4002 |
| Chain | Residue |
| A | CYS3882 |
| A | TYR3883 |
| A | PHE3904 |
| A | ASN3906 |
| A | HIS3907 |
| A | TYR3944 |
| A | PRO3956 |
| A | CYS3957 |
| A | ASN3958 |
| A | LEU3968 |
| A | HOH4105 |
| A | HOH4136 |
| A | ILE3838 |
| A | HIS3839 |
| A | ARG3841 |
| A | GLY3879 |
| A | GLY3881 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 4001 |
| Chain | Residue |
| B | CYS3909 |
| B | CYS3957 |
| B | CYS3959 |
| B | CYS3964 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 4002 |
| Chain | Residue |
| A | GLY3937 |
| B | MET3816 |
| B | ARG3916 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for residue Q2V B 4003 |
| Chain | Residue |
| B | ILE3838 |
| B | HIS3839 |
| B | ARG3841 |
| B | GLY3879 |
| B | GLY3881 |
| B | CYS3882 |
| B | TYR3883 |
| B | PHE3904 |
| B | ASN3906 |
| B | HIS3907 |
| B | TYR3944 |
| B | PRO3956 |
| B | CYS3957 |
| B | ASN3958 |
| B | HOH4104 |
| B | HOH4139 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 232 |
| Details | Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19187761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26886794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F6L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19187761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26886794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W5Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19187761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26886794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F6L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16990798","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187761","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2W5Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F6L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16990798","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187761","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2W5Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F6L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-methylcysteine; by autocatalysis","evidences":[{"source":"PubMed","id":"24235145","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
