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6U9K

MLL1 SET N3861I/Q3867L bound to inhibitor 18 (TC-5153)

Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 4001
ChainResidue
ACYS3909
ACYS3957
ACYS3959
ACYS3964

site_idAC2
Number of Residues17
Detailsbinding site for residue Q2V A 4002
ChainResidue
ACYS3882
ATYR3883
APHE3904
AASN3906
AHIS3907
ATYR3944
APRO3956
ACYS3957
AASN3958
ALEU3968
AHOH4105
AHOH4136
AILE3838
AHIS3839
AARG3841
AGLY3879
AGLY3881

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN B 4001
ChainResidue
BCYS3909
BCYS3957
BCYS3959
BCYS3964

site_idAC4
Number of Residues3
Detailsbinding site for residue GOL B 4002
ChainResidue
AGLY3937
BMET3816
BARG3916

site_idAC5
Number of Residues16
Detailsbinding site for residue Q2V B 4003
ChainResidue
BILE3838
BHIS3839
BARG3841
BGLY3879
BGLY3881
BCYS3882
BTYR3883
BPHE3904
BASN3906
BHIS3907
BTYR3944
BPRO3956
BCYS3957
BASN3958
BHOH4104
BHOH4139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:26886794, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:5F5E, ECO:0007744|PDB:5F6L
ChainResidueDetails
BHIS3839
BARG3841
BASN3958
AHIS3839
AARG3841
AASN3958

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:26886794, ECO:0007744|PDB:2W5Z, ECO:0007744|PDB:5F5E
ChainResidueDetails
ATYR3883
BTYR3883

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:26886794, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:5F5E, ECO:0007744|PDB:5F6L
ChainResidueDetails
AASN3906
BASN3906

site_idSWS_FT_FI4
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:16990798, ECO:0000269|PubMed:19187761, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:2W5Z, ECO:0007744|PDB:5F5E, ECO:0007744|PDB:5F6L
ChainResidueDetails
ACYS3959
BCYS3909
BCYS3957
BCYS3959
ACYS3909
ACYS3957

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:16990798, ECO:0000269|PubMed:19187761, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:2W5Z, ECO:0007744|PDB:5F6L
ChainResidueDetails
ACYS3964
BCYS3964

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: S-methylcysteine; by autocatalysis => ECO:0000269|PubMed:24235145
ChainResidueDetails
ACYS3882
BCYS3882

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PDB entries from 2024-06-12

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