6U9K
MLL1 SET N3861I/Q3867L bound to inhibitor 18 (TC-5153)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Histone-lysine N-methyltransferase | polymer | 158 | 18243.2 | 2 | UniProt (B4DIJ7) Pfam (PF00856) UniProt (by SIFTS) (Q03164) In PDB | Homo sapiens (Human) | |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A, B | 5'-([(3S)-3-amino-3-carboxypropyl]{[1-(3,3-diphenylpropyl)azetidin-3-yl]methyl}amino)-5'-deoxyadenosine | non-polymer | 630.7 | 2 | Chemie (Q2V) | |||
| 4 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 167 | Chemie (HOH) |
Sequence modifications
A, B: 3813 - 3969 (UniProt: B4DIJ7)
| PDB | External Database | Details |
|---|---|---|
| Ser 3812 | - | expression tag |
| Ile 3861 | Asn 215 | engineered mutation |
| Leu 3867 | Gln 221 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36486.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1484.4 | |
| All* | Total formula weight | 37970.8 |
