2W5Z
Ternary Complex of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and histone peptide.
Summary for 2W5Z
Entry DOI | 10.2210/pdb2w5z/pdb |
Related | 2AGH 2J2S 2W5Y |
Descriptor | HISTONE-LYSINE N-METHYLTRANSFERASE HRX, HISTONE PEPTIDE, ZINC ION, ... (6 entities in total) |
Functional Keywords | transcription regulation, chromosomal rearrangement, protein lysine methyltransferase, proto-oncogene, phosphoprotein, ubl conjugation, s-adenosyl-l-methionine, mixed lineage leukaemia, polymorphism, transcription, metal-binding, zinc-finger, dna-binding, bromodomain, transferase, methyltransferase, chromatin regulator, alternative splicing, histone modification, mll1, zinc, kmt2a, nucleus, apoptosis, set domain |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus. MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164 |
Total number of polymer chains | 2 |
Total formula weight | 23939.70 |
Authors | Southall, S.M.,Wong, P.S.,Odho, Z.,Roe, S.M.,Wilson, J.R. (deposition date: 2008-12-15, release date: 2009-02-10, Last modification date: 2011-07-13) |
Primary citation | Southall, S.M.,Wong, P.S.,Odho, Z.,Roe, S.M.,Wilson, J.R. Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks. Mol.Cell, 33:181-, 2009 Cited by PubMed: 19187761DOI: 10.1016/J.MOLCEL.2008.12.029 PDB entries with the same primary citation |
Experimental method |
Structure validation
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