2W5Z
Ternary Complex of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and histone peptide.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A4970 |
| Chain | Residue |
| A | CYS3909 |
| A | CYS3957 |
| A | CYS3959 |
| A | CYS3964 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SAH A4971 |
| Chain | Residue |
| A | PHE3904 |
| A | ASN3906 |
| A | HIS3907 |
| A | TYR3944 |
| A | PRO3956 |
| A | CYS3957 |
| A | ASN3958 |
| C | MLY4 |
| A | ILE3838 |
| A | HIS3839 |
| A | ARG3841 |
| A | TYR3883 |
| A | ARG3903 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A4972 |
| Chain | Residue |
| A | ASN3919 |
| A | LYS3924 |
| A | ARG3932 |
| A | LYS3933 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A4973 |
| Chain | Residue |
| A | ARG3916 |
| A | ARG3936 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoarginine; alternate => ECO:0000305 |
| Chain | Residue | Details |
| C | ARG2 | |
| A | ARG3841 | |
| A | ASN3958 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000250|UniProtKB:P68431, ECO:0000269|PubMed:15681610 |
| Chain | Residue | Details |
| C | THR3 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11747826, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| C | MLY4 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 |
| Chain | Residue | Details |
| C | GLN5 | |
| A | CYS3957 | |
| A | CYS3959 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000250|UniProtKB:P68431 |
| Chain | Residue | Details |
| C | THR6 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000269|PubMed:15485929 |
| Chain | Residue | Details |
| C | ARG8 |
