6T7F
RCR E3 ligase E2-Ubiquitin transthiolation intermediate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000209 | biological_process | protein polyubiquitination |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005768 | cellular_component | endosome |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006281 | biological_process | DNA repair |
| B | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| B | 0006513 | biological_process | protein monoubiquitination |
| B | 0006915 | biological_process | apoptotic process |
| B | 0006974 | biological_process | DNA damage response |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030514 | biological_process | negative regulation of BMP signaling pathway |
| B | 0036211 | biological_process | protein modification process |
| B | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| B | 0051865 | biological_process | protein autoubiquitination |
| B | 0061630 | molecular_function | ubiquitin protein ligase activity |
| B | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070936 | biological_process | protein K48-linked ubiquitination |
| B | 0070979 | biological_process | protein K11-linked ubiquitination |
| B | 0085020 | biological_process | protein K6-linked ubiquitination |
| B | 1903955 | biological_process | positive regulation of protein targeting to mitochondrion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 4701 |
| Chain | Residue |
| A | CYS4390 |
| A | CYS4393 |
| A | HIS4413 |
| A | CYS4416 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 4702 |
| Chain | Residue |
| A | CYS4408 |
| A | HIS4410 |
| A | CYS4437 |
| A | CYS4440 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 4703 |
| Chain | Residue |
| A | CYS4509 |
| A | CYS4537 |
| A | CYS4540 |
| A | CYS4506 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 4704 |
| Chain | Residue |
| A | CYS4549 |
| A | HIS4552 |
| A | CYS4631 |
| A | CYS4634 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 4705 |
| Chain | Residue |
| A | CYS4561 |
| A | CYS4564 |
| A | CYS4579 |
| A | CYS4582 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 4706 |
| Chain | Residue |
| A | CYS4565 |
| A | CYS4600 |
| A | CYS4614 |
| A | HIS4620 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue LWZ B 201 |
| Chain | Residue |
| A | CYS4520 |
| B | ASN77 |
| B | CYS85 |
| B | ASN114 |
| B | ASP117 |
| C | ARG72 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 51 |
| Details | Zinc finger: {"description":"RING-type; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"29643511","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29643511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5O6C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Site: {"description":"Important for catalysis","evidences":[{"source":"PubMed","id":"29643511","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
