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6SGE

Crystal structure of Human RHOB-GTP in complex with nanobody B6

Functional Information from GO Data
ChainGOidnamespacecontents
A0000281biological_processmitotic cytokinesis
A0001525biological_processangiogenesis
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0006886biological_processintracellular protein transport
A0006915biological_processapoptotic process
A0007015biological_processactin filament organization
A0007155biological_processcell adhesion
A0007165biological_processsignal transduction
A0007264biological_processsmall GTPase-mediated signal transduction
A0007266biological_processRho protein signal transduction
A0008333biological_processendosome to lysosome transport
A0010008cellular_componentendosome membrane
A0010595biological_processpositive regulation of endothelial cell migration
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0019003molecular_functionGDP binding
A0030154biological_processcell differentiation
A0030334biological_processregulation of cell migration
A0030336biological_processnegative regulation of cell migration
A0031902cellular_componentlate endosome membrane
A0032154cellular_componentcleavage furrow
A0043065biological_processpositive regulation of apoptotic process
A0045766biological_processpositive regulation of angiogenesis
A0045786biological_processnegative regulation of cell cycle
A0061154biological_processendothelial tube morphogenesis
A0070062cellular_componentextracellular exosome
A0070301biological_processcellular response to hydrogen peroxide
A0071479biological_processcellular response to ionizing radiation
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0099159biological_processregulation of modification of postsynaptic structure
C0000281biological_processmitotic cytokinesis
C0001525biological_processangiogenesis
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005768cellular_componentendosome
C0005769cellular_componentearly endosome
C0005770cellular_componentlate endosome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0006886biological_processintracellular protein transport
C0006915biological_processapoptotic process
C0007015biological_processactin filament organization
C0007155biological_processcell adhesion
C0007165biological_processsignal transduction
C0007264biological_processsmall GTPase-mediated signal transduction
C0007266biological_processRho protein signal transduction
C0008333biological_processendosome to lysosome transport
C0010008cellular_componentendosome membrane
C0010595biological_processpositive regulation of endothelial cell migration
C0015031biological_processprotein transport
C0016020cellular_componentmembrane
C0019003molecular_functionGDP binding
C0030154biological_processcell differentiation
C0030334biological_processregulation of cell migration
C0030336biological_processnegative regulation of cell migration
C0031902cellular_componentlate endosome membrane
C0032154cellular_componentcleavage furrow
C0043065biological_processpositive regulation of apoptotic process
C0045766biological_processpositive regulation of angiogenesis
C0045786biological_processnegative regulation of cell cycle
C0061154biological_processendothelial tube morphogenesis
C0070062cellular_componentextracellular exosome
C0070301biological_processcellular response to hydrogen peroxide
C0071479biological_processcellular response to ionizing radiation
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0099159biological_processregulation of modification of postsynaptic structure
Functional Information from PDB Data
site_idAC1
Number of Residues29
Detailsbinding site for residue GTP A 201
ChainResidue
AGLY14
APRO36
ATHR37
AGLY62
ALYS118
AASP120
ALEU121
ASER160
AALA161
ALYS162
AMG202
AALA15
AHOH316
AHOH329
AHOH353
AHOH362
AHOH376
AHOH408
AHOH422
AHOH440
AHOH460
BASN113
ACYS16
AGLY17
ALYS18
ATHR19
ACYS20
APHE30
ATYR34

site_idAC2
Number of Residues5
Detailsbinding site for residue MG A 202
ChainResidue
ATHR19
ATHR37
AGTP201
AHOH316
AHOH362

site_idAC3
Number of Residues5
Detailsbinding site for residue MG A 203
ChainResidue
AGLU40
ATRP58
AASP59
ASER73
DTYR60

site_idAC4
Number of Residues29
Detailsbinding site for residue GTP C 201
ChainResidue
CGLY14
CALA15
CCYS16
CGLY17
CLYS18
CTHR19
CCYS20
CPHE30
CTYR34
CPRO36
CTHR37
CGLY62
CLYS118
CASP120
CLEU121
CSER160
CALA161
CLYS162
CMG202
CHOH303
CHOH312
CHOH315
CHOH345
CHOH378
CHOH379
CHOH387
CHOH427
CHOH449
DASN113

site_idAC5
Number of Residues5
Detailsbinding site for residue MG C 202
ChainResidue
CTHR19
CTHR37
CGTP201
CHOH315
CHOH345

site_idAC6
Number of Residues5
Detailsbinding site for residue MG C 203
ChainResidue
CVAL38
CTHR60
CALA61
CHOH326
CHOH372

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLY12
AASP59
AASN117
CGLY12
CASP59
CASN117

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: ADP-ribosylasparagine; by botulinum toxin => ECO:0000250
ChainResidueDetails
AASN41
CASN41

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62746
ChainResidueDetails
ATYR154
CTYR154

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR34
CTYR34

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB => ECO:0000269|PubMed:24905543
ChainResidueDetails
ATHR37
CTHR37

226707

PDB entries from 2024-10-30

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