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6S4U

LXRbeta ligand binding domain in comlpex with small molecule inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0006629biological_processlipid metabolic process
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0006629biological_processlipid metabolic process
C0003677molecular_functionDNA binding
C0004879molecular_functionnuclear receptor activity
C0006629biological_processlipid metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue KVK A 501
ChainResidue
APHE271
AARG319
APHE329
ALEU330
APHE340
ALEU345
APHE349
AHIS435
ALEU442
ALEU449
ATHR272
ALEU274
AALA275
ASER278
AGLU281
AMET312
AGLU315
ATHR316

site_idAC2
Number of Residues16
Detailsbinding site for residue KVK B 501
ChainResidue
BSER242
BPHE271
BTHR272
BLEU274
BSER278
BGLU281
BMET312
BGLU315
BTHR316
BARG319
BPHE329
BLEU330
BLEU345
BPHE349
BHIS435
BLEU449

site_idAC3
Number of Residues16
Detailsbinding site for residue KVK C 501
ChainResidue
CPHE271
CLEU274
CALA275
CSER278
CGLU281
CMET312
CGLU315
CTHR316
CARG319
CPHE329
CLEU330
CPHE340
CLEU345
CPHE349
CILE353
CHIS435

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000269|PubMed:20159957
ChainResidueDetails
ALYS410
ALYS448
BLYS410
BLYS448
CLYS410
CLYS448

229183

PDB entries from 2024-12-18

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