6P08
Ternary structure of the E52D mutant of ANT-4'' with Neomycin, AMP and Pyrophosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0046677 | biological_process | response to antibiotic |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016779 | molecular_function | nucleotidyltransferase activity |
| D | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue PPV A 302 |
| Chain | Residue |
| A | GLY38 |
| D | HOH944 |
| A | SER39 |
| A | ARG42 |
| A | SER49 |
| A | THR187 |
| A | MG304 |
| A | AMP306 |
| A | HOH982 |
| D | LYS149 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue MG A 303 |
| Chain | Residue |
| A | ASP50 |
| A | ASP52 |
| A | NMY301 |
| A | MG304 |
| A | AMP306 |
| A | HOH901 |
| A | HOH911 |
| A | HOH913 |
| D | GLU145 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 304 |
| Chain | Residue |
| A | ASP50 |
| A | ASP52 |
| A | PPV302 |
| A | MG303 |
| A | AMP306 |
| A | HOH927 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue MG A 308 |
| Chain | Residue |
| A | GLU145 |
| A | AMP305 |
| A | NMY307 |
| D | ASP50 |
| D | ASP52 |
| D | MG302 |
| D | HOH914 |
| D | HOH923 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue PPV D 301 |
| Chain | Residue |
| A | LYS149 |
| A | AMP305 |
| D | GLY38 |
| D | SER39 |
| D | ARG42 |
| D | SER49 |
| D | THR187 |
| D | MG302 |
| D | HOH901 |
| D | HOH902 |
| D | HOH904 |
| D | HOH906 |
| D | HOH909 |
| D | HOH932 |
| D | HOH972 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue MG D 302 |
| Chain | Residue |
| A | AMP305 |
| A | MG308 |
| D | ASP50 |
| D | ASP52 |
| D | PPV301 |
| D | HOH901 |
| D | HOH902 |
| site_id | AC7 |
| Number of Residues | 29 |
| Details | binding site for residues NMY A 301 and AMP A 306 |
| Chain | Residue |
| A | TYR37 |
| A | GLY38 |
| A | ARG42 |
| A | ASP50 |
| A | ASP52 |
| A | GLU63 |
| A | GLU67 |
| A | GLU76 |
| A | ASP80 |
| A | LEU85 |
| A | TYR88 |
| A | LEU98 |
| A | THR99 |
| A | GLN102 |
| A | THR186 |
| A | PPV302 |
| A | MG303 |
| A | MG304 |
| A | HOH901 |
| A | HOH906 |
| A | HOH909 |
| A | HOH912 |
| A | HOH924 |
| A | HOH950 |
| A | HOH969 |
| A | HOH982 |
| D | GLU141 |
| D | GLU145 |
| D | LYS149 |
| site_id | AC8 |
| Number of Residues | 27 |
| Details | binding site for residues AMP A 305 and NMY A 307 |
| Chain | Residue |
| D | ASP50 |
| D | ASP52 |
| D | GLU63 |
| D | GLU67 |
| D | GLU76 |
| D | ASP80 |
| D | TYR88 |
| D | THR99 |
| D | GLN102 |
| D | PPV301 |
| D | MG302 |
| D | HOH949 |
| A | GLU141 |
| A | GLU145 |
| A | LYS149 |
| A | MG308 |
| A | HOH907 |
| A | HOH930 |
| A | HOH932 |
| A | HOH949 |
| A | HOH952 |
| A | HOH975 |
| A | HOH988 |
| A | HOH993 |
| D | TYR37 |
| D | GLY38 |
| D | ARG42 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 226 |
| Details | Region: {"description":"C-terminal domain","evidences":[{"source":"PubMed","id":"7577914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8218273","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"7577914","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"7577914","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1KNY","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6P06","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38250052","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NML","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NMN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21040710","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UN8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"6UN8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"7577914","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KNY","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38250052","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NMK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NML","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NMN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P01","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UN8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"7577914","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1KNY","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
