6NYO
Crystal structure of a human Cdc34-ubiquitin thioester mimetic
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue U94 A 301 |
| Chain | Residue |
| A | PRO48 |
| A | TRP151 |
| A | HOH559 |
| E | GLY47 |
| E | LYS48 |
| E | GLU51 |
| E | HOH234 |
| E | HOH235 |
| A | ASN50 |
| A | THR51 |
| A | LEU52 |
| A | TYR53 |
| A | PHE58 |
| A | ILE128 |
| A | LEU131 |
| A | ASN132 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | LYS63 |
| A | PHE64 |
| A | PRO65 |
| A | HOH471 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 303 |
| Chain | Residue |
| A | TYR39 |
| A | PHE64 |
| A | ILE66 |
| A | HOH404 |
| A | HOH410 |
| A | HOH418 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO E 101 |
| Chain | Residue |
| E | THR7 |
| E | LEU8 |
| E | LEU69 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO E 102 |
| Chain | Residue |
| A | GLU133 |
| A | ASN135 |
| E | ARG72 |
| E | LEU73 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KskIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| E | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 166 |
| Details | Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | Region: {"description":"Important for ubiquitin transfer","evidences":[{"source":"PubMed","id":"38326650","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38326650","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8PQL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 75 |
| Details | Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)"} |
| Chain | Residue | Details |
