Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6MII

Crystal structure of minichromosome maintenance protein MCM/DNA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005524	molecular_function	ATP binding
B	0003677	molecular_function	DNA binding
B	0005524	molecular_function	ATP binding
C	0003677	molecular_function	DNA binding
C	0005524	molecular_function	ATP binding
D	0003677	molecular_function	DNA binding
D	0005524	molecular_function	ATP binding
E	0003677	molecular_function	DNA binding
E	0005524	molecular_function	ATP binding
F	0003677	molecular_function	DNA binding
F	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue 08T A 2001

Chain	Residue
A	SER302
A	GLN348
A	ASN448
A	ILE495
A	MG2003
A	HOH2101
A	HOH2102
A	HOH2103
B	GLU422
B	GLN423
B	ARG473
A	ILE303
B	PRO559
B	ARG560
B	GLU563
A	TYR304
A	PRO342
A	GLY343
A	THR344
A	ALA345
A	LYS346
A	SER347

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 2002

Chain	Residue
A	HIS144
A	CYS149
A	CYS171
A	CYS174

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 2003

Chain	Residue
A	SER347
A	08T2001
A	HOH2101
A	HOH2102
A	HOH2103

site_id	AC4
Number of Residues	22
Details	binding site for residue 08T B 2001

Chain	Residue
B	SER302
B	ILE303
B	TYR304
B	PRO342
B	GLY343
B	THR344
B	ALA345
B	LYS346
B	SER347
B	GLN348
B	ASN448
B	ILE495
B	MG2003
B	HOH2101
B	HOH2102
C	GLU422
C	GLN423
C	ARG473
C	PRO559
C	ARG560
C	GLU563
C	HOH2101

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN B 2002

Chain	Residue
B	HIS144
B	CYS149
B	CYS171
B	CYS174

site_id	AC6
Number of Residues	5
Details	binding site for residue MG B 2003

Chain	Residue
B	SER347
B	08T2001
B	HOH2101
B	HOH2102
C	HOH2101

site_id	AC7
Number of Residues	21
Details	binding site for residue 08T C 2001

Chain	Residue
C	SER302
C	ILE303
C	TYR304
C	PRO342
C	GLY343
C	THR344
C	ALA345
C	LYS346
C	SER347
C	GLN348
C	ASN448
C	MG2003
C	HOH2102
C	HOH2103
D	GLU422
D	GLN423
D	ARG473
D	PRO559
D	ARG560
D	GLU563
D	HOH2102

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN C 2002

Chain	Residue
C	HIS144
C	CYS149
C	CYS171
C	CYS174

site_id	AC9
Number of Residues	5
Details	binding site for residue MG C 2003

Chain	Residue
C	SER347
C	08T2001
C	HOH2102
C	HOH2103
D	HOH2102

site_id	AD1
Number of Residues	17
Details	binding site for residue ADP D 2001

Chain	Residue
D	GLN348
D	ILE495
D	MG2003
D	HOH2101
D	HOH2104
E	GLU422
E	GLN423
E	PRO559
E	ARG560
E	GLU563
D	SER302
D	TYR304
D	GLY343
D	THR344
D	ALA345
D	LYS346
D	SER347

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN D 2002

Chain	Residue
D	HIS144
D	CYS149
D	CYS171
D	CYS174

site_id	AD3
Number of Residues	5
Details	binding site for residue MG D 2003

Chain	Residue
D	SER347
D	ADP2001
D	HOH2101
D	HOH2103
D	HOH2104

site_id	AD4
Number of Residues	19
Details	binding site for residue ADP E 2001

Chain	Residue
E	SER302
E	ILE303
E	TYR304
E	GLY343
E	THR344
E	ALA345
E	LYS346
E	SER347
E	GLN348
E	ILE495
E	MG2003
E	HOH2102
E	HOH2103
F	GLU422
F	GLN423
F	ARG473
F	PRO559
F	ARG560
F	GLU563

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN E 2002

Chain	Residue
E	HIS144
E	CYS149
E	CYS171
E	CYS174

site_id	AD6
Number of Residues	5
Details	binding site for residue MG E 2003

Chain	Residue
E	SER347
E	ADP2001
E	HOH2101
E	HOH2102
E	HOH2103

site_id	AD7
Number of Residues	17
Details	binding site for residue ADP F 2001

Chain	Residue
A	PRO559
A	ARG560
A	GLU563
F	SER302
F	ILE303
F	TYR304
F	PRO342
F	GLY343
F	THR344
F	ALA345
F	LYS346
F	SER347
F	GLN348
F	ILE495
F	MG2003
F	HOH2102
F	HOH2103

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN F 2002

Chain	Residue
F	HIS144
F	CYS149
F	CYS171
F	CYS174

site_id	AD9
Number of Residues	5
Details	binding site for residue MG F 2003

Chain	Residue
F	SER347
F	ADP2001
F	HOH2101
F	HOH2102
F	HOH2103

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Motif: {"description":"Walker A","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	18
Details	Motif: {"description":"Walker B","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18417534","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36499022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FDG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36499022","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31308367","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31308367","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36499022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31308367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	6
Details	Site: {"description":"Arginine finger","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17964268","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)