6LUR

Human PUF60 UHM domain (thioredoxin fusion) in complex with a small molecule binder

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0015035	molecular_function	protein-disulfide reductase activity
A	0030337	molecular_function	DNA polymerase processivity factor activity
A	0045454	biological_process	cell redox homeostasis
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0015035	molecular_function	protein-disulfide reductase activity
B	0030337	molecular_function	DNA polymerase processivity factor activity
B	0045454	biological_process	cell redox homeostasis
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0015035	molecular_function	protein-disulfide reductase activity
C	0030337	molecular_function	DNA polymerase processivity factor activity
C	0045454	biological_process	cell redox homeostasis
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0015035	molecular_function	protein-disulfide reductase activity
D	0030337	molecular_function	DNA polymerase processivity factor activity
D	0045454	biological_process	cell redox homeostasis
E	0003676	molecular_function	nucleic acid binding
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0015035	molecular_function	protein-disulfide reductase activity
E	0030337	molecular_function	DNA polymerase processivity factor activity
E	0045454	biological_process	cell redox homeostasis
F	0003676	molecular_function	nucleic acid binding
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0015035	molecular_function	protein-disulfide reductase activity
F	0030337	molecular_function	DNA polymerase processivity factor activity
F	0045454	biological_process	cell redox homeostasis
G	0003676	molecular_function	nucleic acid binding
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0015035	molecular_function	protein-disulfide reductase activity
G	0030337	molecular_function	DNA polymerase processivity factor activity
G	0045454	biological_process	cell redox homeostasis
H	0003676	molecular_function	nucleic acid binding
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0015035	molecular_function	protein-disulfide reductase activity
H	0030337	molecular_function	DNA polymerase processivity factor activity
H	0045454	biological_process	cell redox homeostasis

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue EVU B 601

Chain	Residue
B	MET466
B	LEU476
B	GLU479
B	VAL480
B	GLU483
B	PHE534
B	HOH773

---

site_id	AC2
Number of Residues	6
Details	binding site for residue EVU B 602

Chain	Residue
B	ILE508
C	LEU361
C	LYS362
C	GLY428
B	LYS499
B	GLU504

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EVU B 603

Chain	Residue
B	ALA449
B	GLY453
B	SER454
B	ALA455
F	MET381

---

site_id	AC4
Number of Residues	6
Details	binding site for residue EVU C 601

Chain	Residue
C	MET466
C	LEU476
C	GLU479
C	GLU483
C	CYS484
C	PHE534

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EVU C 602

Chain	Residue
C	ALA449
C	GLY453
C	SER454
C	ALA455

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EVU D 601

Chain	Residue
D	MET466
D	GLU479
D	GLU483
D	CYS484
D	PHE534

---

site_id	AC7
Number of Residues	6
Details	binding site for residue EVU D 602

Chain	Residue
A	LYS499
A	ILE508
D	ASP357
D	LEU361
D	LYS362
D	GLY428

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EVU E 601

Chain	Residue
E	LEU463
E	MET466
E	LEU476
E	GLU479
E	VAL480
E	GLU483
E	PHE534

---

Functional Information from PROSITE/UniProt

site_id	PS00194
Number of Residues	19
Details	THIOREDOXIN_1 Thioredoxin family active site. LVdFWaeWCGPCKmIapiL

Chain	Residue	Details
A	LEU368-LEU386

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Active site: {"description":"Nucleophile"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Site: {"description":"Deprotonates C-terminal active site Cys"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Site: {"description":"Contributes to redox potential value"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	107
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	696
Details	Domain: {"description":"RRM 3; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---