6LKN

Crystal structure of ATP11C-CDC50A in PtdSer-bound E2P state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0005215	molecular_function	transporter activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005765	cellular_component	lysosomal membrane
A	0005768	cellular_component	endosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006869	biological_process	lipid transport
A	0012505	cellular_component	endomembrane system
A	0015914	biological_process	phospholipid transport
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0031901	cellular_component	early endosome membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0045332	biological_process	phospholipid translocation
A	0046872	molecular_function	metal ion binding
A	0055037	cellular_component	recycling endosome
A	0055038	cellular_component	recycling endosome membrane
A	0090555	molecular_function	phosphatidylethanolamine flippase activity
A	0090556	molecular_function	phosphatidylserine floppase activity
A	0140326	molecular_function	ATPase-coupled intramembrane lipid transporter activity
A	0140331	biological_process	aminophospholipid translocation
A	0140346	molecular_function	phosphatidylserine flippase activity
A	1990531	cellular_component	phospholipid-translocating ATPase complex
C	0005198	molecular_function	structural molecule activity
C	0005515	molecular_function	protein binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005794	cellular_component	Golgi apparatus
C	0005886	cellular_component	plasma membrane
C	0006855	biological_process	xenobiotic transmembrane transport
C	0006869	biological_process	lipid transport
C	0010976	biological_process	positive regulation of neuron projection development
C	0015247	molecular_function	aminophospholipid flippase activity
C	0015917	biological_process	aminophospholipid transport
C	0016020	cellular_component	membrane
C	0016324	cellular_component	apical plasma membrane
C	0030658	cellular_component	transport vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0031901	cellular_component	early endosome membrane
C	0031902	cellular_component	late endosome membrane
C	0035577	cellular_component	azurophil granule membrane
C	0035579	cellular_component	specific granule membrane
C	0036010	biological_process	protein localization to endosome
C	0045332	biological_process	phospholipid translocation
C	0061092	biological_process	positive regulation of phospholipid translocation
C	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
C	0140331	biological_process	aminophospholipid translocation
C	1990531	cellular_component	phospholipid-translocating ATPase complex
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0005215	molecular_function	transporter activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005765	cellular_component	lysosomal membrane
E	0005768	cellular_component	endosome
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005886	cellular_component	plasma membrane
E	0006869	biological_process	lipid transport
E	0012505	cellular_component	endomembrane system
E	0015914	biological_process	phospholipid transport
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0031901	cellular_component	early endosome membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0045332	biological_process	phospholipid translocation
E	0046872	molecular_function	metal ion binding
E	0055037	cellular_component	recycling endosome
E	0055038	cellular_component	recycling endosome membrane
E	0090555	molecular_function	phosphatidylethanolamine flippase activity
E	0090556	molecular_function	phosphatidylserine floppase activity
E	0140326	molecular_function	ATPase-coupled intramembrane lipid transporter activity
E	0140331	biological_process	aminophospholipid translocation
E	0140346	molecular_function	phosphatidylserine flippase activity
E	1990531	cellular_component	phospholipid-translocating ATPase complex
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005783	cellular_component	endoplasmic reticulum
F	0005794	cellular_component	Golgi apparatus
F	0005886	cellular_component	plasma membrane
F	0006855	biological_process	xenobiotic transmembrane transport
F	0006869	biological_process	lipid transport
F	0010976	biological_process	positive regulation of neuron projection development
F	0015247	molecular_function	aminophospholipid flippase activity
F	0015917	biological_process	aminophospholipid transport
F	0016020	cellular_component	membrane
F	0016324	cellular_component	apical plasma membrane
F	0030658	cellular_component	transport vesicle membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0031901	cellular_component	early endosome membrane
F	0031902	cellular_component	late endosome membrane
F	0035577	cellular_component	azurophil granule membrane
F	0035579	cellular_component	specific granule membrane
F	0036010	biological_process	protein localization to endosome
F	0045332	biological_process	phospholipid translocation
F	0061092	biological_process	positive regulation of phospholipid translocation
F	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
F	0140331	biological_process	aminophospholipid translocation
F	1990531	cellular_component	phospholipid-translocating ATPase complex
I	0000166	molecular_function	nucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0005215	molecular_function	transporter activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005765	cellular_component	lysosomal membrane
I	0005768	cellular_component	endosome
I	0005783	cellular_component	endoplasmic reticulum
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0005886	cellular_component	plasma membrane
I	0006869	biological_process	lipid transport
I	0012505	cellular_component	endomembrane system
I	0015914	biological_process	phospholipid transport
I	0016020	cellular_component	membrane
I	0016887	molecular_function	ATP hydrolysis activity
I	0031901	cellular_component	early endosome membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0045332	biological_process	phospholipid translocation
I	0046872	molecular_function	metal ion binding
I	0055037	cellular_component	recycling endosome
I	0055038	cellular_component	recycling endosome membrane
I	0090555	molecular_function	phosphatidylethanolamine flippase activity
I	0090556	molecular_function	phosphatidylserine floppase activity
I	0140326	molecular_function	ATPase-coupled intramembrane lipid transporter activity
I	0140331	biological_process	aminophospholipid translocation
I	0140346	molecular_function	phosphatidylserine flippase activity
I	1990531	cellular_component	phospholipid-translocating ATPase complex
J	0005198	molecular_function	structural molecule activity
J	0005515	molecular_function	protein binding
J	0005783	cellular_component	endoplasmic reticulum
J	0005794	cellular_component	Golgi apparatus
J	0005886	cellular_component	plasma membrane
J	0006855	biological_process	xenobiotic transmembrane transport
J	0006869	biological_process	lipid transport
J	0010976	biological_process	positive regulation of neuron projection development
J	0015247	molecular_function	aminophospholipid flippase activity
J	0015917	biological_process	aminophospholipid transport
J	0016020	cellular_component	membrane
J	0016324	cellular_component	apical plasma membrane
J	0030658	cellular_component	transport vesicle membrane
J	0031410	cellular_component	cytoplasmic vesicle
J	0031901	cellular_component	early endosome membrane
J	0031902	cellular_component	late endosome membrane
J	0035577	cellular_component	azurophil granule membrane
J	0035579	cellular_component	specific granule membrane
J	0036010	biological_process	protein localization to endosome
J	0045332	biological_process	phospholipid translocation
J	0061092	biological_process	positive regulation of phospholipid translocation
J	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
J	0140331	biological_process	aminophospholipid translocation
J	1990531	cellular_component	phospholipid-translocating ATPase complex
M	0000166	molecular_function	nucleotide binding
M	0000287	molecular_function	magnesium ion binding
M	0005215	molecular_function	transporter activity
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005765	cellular_component	lysosomal membrane
M	0005768	cellular_component	endosome
M	0005783	cellular_component	endoplasmic reticulum
M	0005789	cellular_component	endoplasmic reticulum membrane
M	0005886	cellular_component	plasma membrane
M	0006869	biological_process	lipid transport
M	0012505	cellular_component	endomembrane system
M	0015914	biological_process	phospholipid transport
M	0016020	cellular_component	membrane
M	0016887	molecular_function	ATP hydrolysis activity
M	0031901	cellular_component	early endosome membrane
M	0034220	biological_process	monoatomic ion transmembrane transport
M	0045332	biological_process	phospholipid translocation
M	0046872	molecular_function	metal ion binding
M	0055037	cellular_component	recycling endosome
M	0055038	cellular_component	recycling endosome membrane
M	0090555	molecular_function	phosphatidylethanolamine flippase activity
M	0090556	molecular_function	phosphatidylserine floppase activity
M	0140326	molecular_function	ATPase-coupled intramembrane lipid transporter activity
M	0140331	biological_process	aminophospholipid translocation
M	0140346	molecular_function	phosphatidylserine flippase activity
M	1990531	cellular_component	phospholipid-translocating ATPase complex
N	0005198	molecular_function	structural molecule activity
N	0005515	molecular_function	protein binding
N	0005783	cellular_component	endoplasmic reticulum
N	0005794	cellular_component	Golgi apparatus
N	0005886	cellular_component	plasma membrane
N	0006855	biological_process	xenobiotic transmembrane transport
N	0006869	biological_process	lipid transport
N	0010976	biological_process	positive regulation of neuron projection development
N	0015247	molecular_function	aminophospholipid flippase activity
N	0015917	biological_process	aminophospholipid transport
N	0016020	cellular_component	membrane
N	0016324	cellular_component	apical plasma membrane
N	0030658	cellular_component	transport vesicle membrane
N	0031410	cellular_component	cytoplasmic vesicle
N	0031901	cellular_component	early endosome membrane
N	0031902	cellular_component	late endosome membrane
N	0035577	cellular_component	azurophil granule membrane
N	0035579	cellular_component	specific granule membrane
N	0036010	biological_process	protein localization to endosome
N	0045332	biological_process	phospholipid translocation
N	0061092	biological_process	positive regulation of phospholipid translocation
N	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
N	0140331	biological_process	aminophospholipid translocation
N	1990531	cellular_component	phospholipid-translocating ATPase complex

Functional Information from PROSITE/UniProt

site_id	PS00154
Number of Residues	7
Details	ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT

Chain	Residue	Details
A	BFD409-THR415

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	244
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
C	ALA2-THR49
A	TRP1067-LEU1087
E	PHE64-VAL82
E	THR84-ILE104
E	ILE288-THR308
E	PHE344-GLU364
E	PHE877-PHE897
E	ALA906-LEU926
E	LEU953-GLY973
E	TRP993-LEU1013
E	PHE1024-ILE1044
C	ASN347-ILE361
E	TRP1067-LEU1087
I	PHE64-VAL82
I	THR84-ILE104
I	ILE288-THR308
I	PHE344-GLU364
I	PHE877-PHE897
I	ALA906-LEU926
I	LEU953-GLY973
I	TRP993-LEU1013
I	PHE1024-ILE1044
F	ALA2-THR49
I	TRP1067-LEU1087
M	PHE64-VAL82
M	THR84-ILE104
M	ILE288-THR308
M	PHE344-GLU364
M	PHE877-PHE897
M	ALA906-LEU926
M	LEU953-GLY973
M	TRP993-LEU1013
M	PHE1024-ILE1044
F	ASN347-ILE361
M	TRP1067-LEU1087
J	ALA2-THR49
J	ASN347-ILE361
N	ALA2-THR49
N	ASN347-ILE361
A	PHE1024-ILE1044

---

site_id	SWS_FT_FI2
Number of Residues	160
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
C	VAL50-VAL70
E	TRP1045-THR1066
I	ASP83
I	LEU309-ASP343
I	SER898-ALA905
I	THR974-ASN992
I	TRP1045-THR1066
M	ASP83
M	LEU309-ASP343
M	SER898-ALA905
M	THR974-ASN992
C	GLY326-ILE346
M	TRP1045-THR1066
F	VAL50-VAL70
F	GLY326-ILE346
J	VAL50-VAL70
J	GLY326-ILE346
N	VAL50-VAL70
N	GLY326-ILE346
E	THR974-ASN992

---

site_id	SWS_FT_FI3
Number of Residues	1016
Details	TOPO_DOM: Exoplasmic loop => ECO:0000255

Chain	Residue	Details
C	THR71-LEU325
E	LYS1088-LEU1129
I	LYS105-SER287
I	MET365-TYR876
I	GLU927-GLN952
I	ASP1014-HIS1023
I	LYS1088-LEU1129
M	LYS105-SER287
M	MET365-TYR876
M	GLU927-GLN952
M	ASP1014-HIS1023
F	THR71-LEU325
M	LYS1088-LEU1129
J	THR71-LEU325
N	THR71-LEU325
A	LYS1088-LEU1129
E	LYS105-SER287
E	MET365-TYR876
E	GLU927-GLN952
E	ASP1014-HIS1023

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
C	ALA2
F	ALA2
J	ALA2
N	ALA2

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:31416931, ECO:0007744|PDB:6K7G, ECO:0007744|PDB:6K7H, ECO:0007744|PDB:6K7I, ECO:0007744|PDB:6K7J, ECO:0007744|PDB:6K7K, ECO:0007744|PDB:6K7L, ECO:0007744|PDB:6K7M

Chain	Residue	Details
C	ASN107
E	ASN819
I	BFD409
I	LYS410
I	THR411
I	PHE540
I	ASN819
M	BFD409
M	LYS410
M	THR411
M	PHE540
F	ASN107
M	ASN819
J	ASN107
N	ASN107
A	ASN819
E	BFD409
E	LYS410
E	THR411
E	PHE540

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:31416931, ECO:0007744|PDB:6K7G, ECO:0007744|PDB:6K7H, ECO:0007744|PDB:6K7I, ECO:0007744|PDB:6K7J, ECO:0007744|PDB:6K7K, ECO:0007744|PDB:6K7L, ECO:0007744|PDB:6K7M

Chain	Residue	Details
C	ASN180
E	LYS563
E	ARG594
E	THR674
E	GLY675
E	ASP676
E	ARG789
E	LYS795
I	GLU498
I	LYS563
I	ARG594
F	ASN180
I	THR674
I	GLY675
I	ASP676
I	ARG789
I	LYS795
M	GLU498
M	LYS563
M	ARG594
M	THR674
M	GLY675
J	ASN180
M	ASP676
M	ARG789
M	LYS795
N	ASN180
A	GLY675
A	ASP676
A	ARG789
A	LYS795
E	GLU498

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973

Chain	Residue	Details
C	GLN190
F	GLN190
J	GLN190
N	GLN190
I	ASP816
I	ASP820
M	ASP816
M	ASP820

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:31416931, ECO:0007744|PDB:6K7G, ECO:0007744|PDB:6K7H, ECO:0007744|PDB:6K7I, ECO:0007744|PDB:6K7J, ECO:0007744|PDB:6K7K, ECO:0007744|PDB:6K7L, ECO:0007744|PDB:6K7M

Chain	Residue	Details
C	ASN294
F	ASN294
J	ASN294
N	ASN294

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	SITE: Cleavage; by CASP3 => ECO:0000269|PubMed:24904167

Chain	Residue	Details
A	ASP445
E	ASP445
I	ASP445
M	ASP445

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	SITE: Cleavage; by CASP3 and CASP7 => ECO:0000269|PubMed:24904167

Chain	Residue	Details
A	ASP481
E	ASP481
I	ASP481
M	ASP481

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER442
E	SER442
I	SER442
M	SER442

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1105
E	SER1105
I	SER1105
M	SER1105

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:29123098, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1113
E	SER1113
I	SER1113
M	SER1113

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1123
E	SER1123
I	SER1123
M	SER1123

---