6LKN

Crystal structure of ATP11C-CDC50A in PtdSer-bound E2P state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0005215	molecular_function	transporter activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005765	cellular_component	lysosomal membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006869	biological_process	lipid transport
A	0012505	cellular_component	endomembrane system
A	0015914	biological_process	phospholipid transport
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0031901	cellular_component	early endosome membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0045332	biological_process	phospholipid translocation
A	0046872	molecular_function	metal ion binding
A	0055037	cellular_component	recycling endosome
A	0055038	cellular_component	recycling endosome membrane
A	0090555	molecular_function	phosphatidylethanolamine flippase activity
A	0090556	molecular_function	phosphatidylserine floppase activity
A	0140326	molecular_function	ATPase-coupled intramembrane lipid transporter activity
A	0140331	biological_process	aminophospholipid translocation
A	0140346	molecular_function	phosphatidylserine flippase activity
A	1990531	cellular_component	phospholipid-translocating ATPase complex
C	0005198	molecular_function	structural molecule activity
C	0005515	molecular_function	protein binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005794	cellular_component	Golgi apparatus
C	0005886	cellular_component	plasma membrane
C	0006855	biological_process	xenobiotic transmembrane transport
C	0006869	biological_process	lipid transport
C	0010976	biological_process	positive regulation of neuron projection development
C	0015247	molecular_function	aminophospholipid flippase activity
C	0015917	biological_process	aminophospholipid transport
C	0016020	cellular_component	membrane
C	0016324	cellular_component	apical plasma membrane
C	0030658	cellular_component	transport vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0031901	cellular_component	early endosome membrane
C	0031902	cellular_component	late endosome membrane
C	0035577	cellular_component	azurophil granule membrane
C	0035579	cellular_component	specific granule membrane
C	0036010	biological_process	protein localization to endosome
C	0045332	biological_process	phospholipid translocation
C	0061092	biological_process	positive regulation of phospholipid translocation
C	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
C	0140331	biological_process	aminophospholipid translocation
C	1990531	cellular_component	phospholipid-translocating ATPase complex
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0005215	molecular_function	transporter activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005765	cellular_component	lysosomal membrane
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005886	cellular_component	plasma membrane
E	0006869	biological_process	lipid transport
E	0012505	cellular_component	endomembrane system
E	0015914	biological_process	phospholipid transport
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0031901	cellular_component	early endosome membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0045332	biological_process	phospholipid translocation
E	0046872	molecular_function	metal ion binding
E	0055037	cellular_component	recycling endosome
E	0055038	cellular_component	recycling endosome membrane
E	0090555	molecular_function	phosphatidylethanolamine flippase activity
E	0090556	molecular_function	phosphatidylserine floppase activity
E	0140326	molecular_function	ATPase-coupled intramembrane lipid transporter activity
E	0140331	biological_process	aminophospholipid translocation
E	0140346	molecular_function	phosphatidylserine flippase activity
E	1990531	cellular_component	phospholipid-translocating ATPase complex
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005783	cellular_component	endoplasmic reticulum
F	0005794	cellular_component	Golgi apparatus
F	0005886	cellular_component	plasma membrane
F	0006855	biological_process	xenobiotic transmembrane transport
F	0006869	biological_process	lipid transport
F	0010976	biological_process	positive regulation of neuron projection development
F	0015247	molecular_function	aminophospholipid flippase activity
F	0015917	biological_process	aminophospholipid transport
F	0016020	cellular_component	membrane
F	0016324	cellular_component	apical plasma membrane
F	0030658	cellular_component	transport vesicle membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0031901	cellular_component	early endosome membrane
F	0031902	cellular_component	late endosome membrane
F	0035577	cellular_component	azurophil granule membrane
F	0035579	cellular_component	specific granule membrane
F	0036010	biological_process	protein localization to endosome
F	0045332	biological_process	phospholipid translocation
F	0061092	biological_process	positive regulation of phospholipid translocation
F	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
F	0140331	biological_process	aminophospholipid translocation
F	1990531	cellular_component	phospholipid-translocating ATPase complex
I	0000166	molecular_function	nucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0005215	molecular_function	transporter activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005765	cellular_component	lysosomal membrane
I	0005783	cellular_component	endoplasmic reticulum
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0005886	cellular_component	plasma membrane
I	0006869	biological_process	lipid transport
I	0012505	cellular_component	endomembrane system
I	0015914	biological_process	phospholipid transport
I	0016020	cellular_component	membrane
I	0016887	molecular_function	ATP hydrolysis activity
I	0031901	cellular_component	early endosome membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0045332	biological_process	phospholipid translocation
I	0046872	molecular_function	metal ion binding
I	0055037	cellular_component	recycling endosome
I	0055038	cellular_component	recycling endosome membrane
I	0090555	molecular_function	phosphatidylethanolamine flippase activity
I	0090556	molecular_function	phosphatidylserine floppase activity
I	0140326	molecular_function	ATPase-coupled intramembrane lipid transporter activity
I	0140331	biological_process	aminophospholipid translocation
I	0140346	molecular_function	phosphatidylserine flippase activity
I	1990531	cellular_component	phospholipid-translocating ATPase complex
J	0005198	molecular_function	structural molecule activity
J	0005515	molecular_function	protein binding
J	0005783	cellular_component	endoplasmic reticulum
J	0005794	cellular_component	Golgi apparatus
J	0005886	cellular_component	plasma membrane
J	0006855	biological_process	xenobiotic transmembrane transport
J	0006869	biological_process	lipid transport
J	0010976	biological_process	positive regulation of neuron projection development
J	0015247	molecular_function	aminophospholipid flippase activity
J	0015917	biological_process	aminophospholipid transport
J	0016020	cellular_component	membrane
J	0016324	cellular_component	apical plasma membrane
J	0030658	cellular_component	transport vesicle membrane
J	0031410	cellular_component	cytoplasmic vesicle
J	0031901	cellular_component	early endosome membrane
J	0031902	cellular_component	late endosome membrane
J	0035577	cellular_component	azurophil granule membrane
J	0035579	cellular_component	specific granule membrane
J	0036010	biological_process	protein localization to endosome
J	0045332	biological_process	phospholipid translocation
J	0061092	biological_process	positive regulation of phospholipid translocation
J	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
J	0140331	biological_process	aminophospholipid translocation
J	1990531	cellular_component	phospholipid-translocating ATPase complex
M	0000166	molecular_function	nucleotide binding
M	0000287	molecular_function	magnesium ion binding
M	0005215	molecular_function	transporter activity
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005765	cellular_component	lysosomal membrane
M	0005783	cellular_component	endoplasmic reticulum
M	0005789	cellular_component	endoplasmic reticulum membrane
M	0005886	cellular_component	plasma membrane
M	0006869	biological_process	lipid transport
M	0012505	cellular_component	endomembrane system
M	0015914	biological_process	phospholipid transport
M	0016020	cellular_component	membrane
M	0016887	molecular_function	ATP hydrolysis activity
M	0031901	cellular_component	early endosome membrane
M	0034220	biological_process	monoatomic ion transmembrane transport
M	0045332	biological_process	phospholipid translocation
M	0046872	molecular_function	metal ion binding
M	0055037	cellular_component	recycling endosome
M	0055038	cellular_component	recycling endosome membrane
M	0090555	molecular_function	phosphatidylethanolamine flippase activity
M	0090556	molecular_function	phosphatidylserine floppase activity
M	0140326	molecular_function	ATPase-coupled intramembrane lipid transporter activity
M	0140331	biological_process	aminophospholipid translocation
M	0140346	molecular_function	phosphatidylserine flippase activity
M	1990531	cellular_component	phospholipid-translocating ATPase complex
N	0005198	molecular_function	structural molecule activity
N	0005515	molecular_function	protein binding
N	0005783	cellular_component	endoplasmic reticulum
N	0005794	cellular_component	Golgi apparatus
N	0005886	cellular_component	plasma membrane
N	0006855	biological_process	xenobiotic transmembrane transport
N	0006869	biological_process	lipid transport
N	0010976	biological_process	positive regulation of neuron projection development
N	0015247	molecular_function	aminophospholipid flippase activity
N	0015917	biological_process	aminophospholipid transport
N	0016020	cellular_component	membrane
N	0016324	cellular_component	apical plasma membrane
N	0030658	cellular_component	transport vesicle membrane
N	0031410	cellular_component	cytoplasmic vesicle
N	0031901	cellular_component	early endosome membrane
N	0031902	cellular_component	late endosome membrane
N	0035577	cellular_component	azurophil granule membrane
N	0035579	cellular_component	specific granule membrane
N	0036010	biological_process	protein localization to endosome
N	0045332	biological_process	phospholipid translocation
N	0061092	biological_process	positive regulation of phospholipid translocation
N	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
N	0140331	biological_process	aminophospholipid translocation
N	1990531	cellular_component	phospholipid-translocating ATPase complex

Functional Information from PROSITE/UniProt

site_id	PS00154
Number of Residues	7
Details	ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT

Chain	Residue	Details
A	BFD409-THR415

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	952
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	324
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	864
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"description":"4-aspartylphosphate intermediate","evidences":[{"source":"UniProtKB","id":"Q9Y2Q0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9Y2Q0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04191","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32493773","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6LKN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Site: {"description":"Cleavage; by CASP3, CASP6 and CASP7","evidences":[{"source":"PubMed","id":"24904167","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Site: {"description":"Cleavage; by CASP3","evidences":[{"source":"PubMed","id":"24904167","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Site: {"description":"Cleavage; by CASP3 and CASP7","evidences":[{"source":"PubMed","id":"24904167","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1016
Details	Topological domain: {"description":"Exoplasmic loop","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"31416931","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6K7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31416931","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6K7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31416931","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6K7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---