6L6N
hASIC1a co-crystallized with Nafamostat
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0015280 | molecular_function | ligand-gated sodium channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0005272 | molecular_function | sodium channel activity |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0015280 | molecular_function | ligand-gated sodium channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0005272 | molecular_function | sodium channel activity |
| C | 0006814 | biological_process | sodium ion transport |
| C | 0015280 | molecular_function | ligand-gated sodium channel activity |
| C | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS01206 |
| Number of Residues | 21 |
| Details | ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC |
| Chain | Residue | Details |
| A | TYR305-CYS325 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical => ECO:0000305|PubMed:34319232, ECO:0007744|PDB:7RNN |
| Chain | Residue | Details |
| A | PHE50-GLN66 | |
| B | PHE50-GLN66 | |
| C | PHE50-GLN66 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1080 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:34319232, ECO:0007744|PDB:7RNN |
| Chain | Residue | Details |
| A | TYR67-GLU427 | |
| B | TYR67-GLU427 | |
| C | TYR67-GLU427 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 90 |
| Details | TRANSMEM: Discontinuously helical => ECO:0000305|PubMed:34319232, ECO:0007744|PDB:7RNN |
| Chain | Residue | Details |
| A | ILE428-TYR458 | |
| B | ILE428-TYR458 | |
| C | ILE428-TYR458 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | SITE: Involved in channel desensitization; the process by which the channel becomes unresponsive to proton stimulation => ECO:0000250|UniProtKB:Q1XA76 |
| Chain | Residue | Details |
| A | GLU79 | |
| B | GLU79 | |
| C | GLU79 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | SITE: Involved in the inhibition by the spider venom psalmotoxin-1 => ECO:0000269|PubMed:19654327 |
| Chain | Residue | Details |
| A | PHE352 | |
| B | PHE352 | |
| C | PHE352 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | SITE: Involved in proton-dependent gating => ECO:0000269|PubMed:19654327 |
| Chain | Residue | Details |
| A | ASP357 | |
| B | ASP357 | |
| C | ASP357 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:32915133, ECO:0000269|PubMed:34319232, ECO:0007744|PDB:7CFS, ECO:0007744|PDB:7CFT, ECO:0007744|PDB:7RNN |
| Chain | Residue | Details |
| A | ASN368 | |
| A | ASN395 | |
| B | ASN368 | |
| B | ASN395 | |
| C | ASN368 | |
| C | ASN395 |
