Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0015280 | molecular_function | ligand-gated sodium channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0005272 | molecular_function | sodium channel activity |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0015280 | molecular_function | ligand-gated sodium channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0005272 | molecular_function | sodium channel activity |
| C | 0006814 | biological_process | sodium ion transport |
| C | 0015280 | molecular_function | ligand-gated sodium channel activity |
| C | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS01206 |
| Number of Residues | 21 |
| Details | ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC |
| Chain | Residue | Details |
| A | TYR305-CYS325 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 69 |
| Details | TRANSMEM: Helical => ECO:0000250 |
| Chain | Residue | Details |
| A | TRP46-PHE69 | |
| B | TRP46-PHE69 | |
| C | TRP46-PHE69 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1071 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS70-GLU427 | |
| B | HIS70-GLU427 | |
| C | HIS70-GLU427 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 78 |
| Details | TRANSMEM: Discontinuously helical => ECO:0000250 |
| Chain | Residue | Details |
| A | ILE428-PHE454 | |
| B | ILE428-PHE454 | |
| C | ILE428-PHE454 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | SITE: Important for channel gating => ECO:0000250 |
| Chain | Residue | Details |
| B | TYR71 | |
| B | TRP287 | |
| C | TYR71 | |
| C | TRP287 | |
| A | TYR71 | |
| A | TRP287 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | SITE: Important for channel desensitizing => ECO:0000250 |
| Chain | Residue | Details |
| B | GLU79 | |
| C | GLU79 | |
| A | GLU79 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | SITE: Important for interaction with the spider venom psalmotoxin-1 => ECO:0000269|PubMed:19654327 |
| Chain | Residue | Details |
| B | PHE352 | |
| C | PHE352 | |
| A | PHE352 | |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | SITE: Key residue for defining the pH sensitivity of ASIC1 (isoform 1) => ECO:0000269|PubMed:19654327 |
| Chain | Residue | Details |
| B | ASP357 | |
| C | ASP357 | |
| A | ASP357 | |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN368 | |
| B | ASN395 | |
| C | ASN368 | |
| C | ASN395 | |
| A | ASN368 | |
| A | ASN395 | |
