6L6N

hASIC1a co-crystallized with Nafamostat

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Acid-sensing ion channel 1	polymer	454	51701.9	3	UniProt (P78348) Pfam (PF00858)	Homo sapiens (Human)	ASIC1,Amiloride-sensitive cation channel 2,neuronal,Brain sodium channel 2,BNaC2
2	D (A)	2-acetamido-2-deoxy-alpha-D-glucopyranose	non-polymer		221.2	1	Chemie (NDG)
3	E, F, I, J (A, B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
4	G, K (B, C)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5	H (B)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
6	L, M, N (A, B, C)	water	water		18.0	43	Chemie (HOH)

Sequence modifications

A, B, C: 25 - 464 (UniProt: P78348)

PDB	External Database	Details
Gly 11	-	expression tag
Ser 12	-	expression tag
Gly 13	-	expression tag
Gly 14	-	expression tag
Ser 15	-	expression tag
Gly 16	-	expression tag
Leu 17	-	expression tag
Glu 18	-	expression tag
Val 19	-	expression tag
Leu 20	-	expression tag
Phe 21	-	expression tag
Gln 22	-	expression tag
Gly 23	-	expression tag
Pro 24	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	155105.6
Non-Polymers*	Number of molecules	8
	Total formula weight	1239.0
All*	Total formula weight	156344.6

*Water molecules are not included.