6IRZ

Crystal structure of the zebrafish cap-specific adenosine methyltransferase bound to SAH and m7G-capped RNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016422	molecular_function	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
A	0099122	molecular_function	RNA polymerase II C-terminal domain binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue SAH A 701

Chain	Residue
A	GLN495
A	ASN522
A	CYS529
A	SER530
A	ALA531
A	PHE545
A	GLU556
A	ASN558
A	PRO560
A	HOH804
A	HOH820
A	GLY496
A	HOH829
A	HOH878
A	HOH909
A	LEU498
A	PHE503
A	GLU515
A	CYS516
A	PHE517
A	ALA518
A	SER519

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site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 702

Chain	Residue
A	LEU241
A	LYS245
A	PRO253
A	LEU254
A	ALA531
A	HOH804

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site_id	AC3
Number of Residues	8
Details	binding site for residue EDO A 703

Chain	Residue
A	PRO201
A	HIS202
A	PRO203
A	PRO419
A	PRO420
A	LYS468
A	SER471
A	HOH862

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site_id	AC4
Number of Residues	6
Details	binding site for residue EDO A 704

Chain	Residue
A	ARG413
A	LEU414
A	ASP462
A	PHE538
A	HOH807
A	HOH821

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site_id	AC5
Number of Residues	9
Details	binding site for residue M7G A 705

Chain	Residue
A	ARG239
A	ARG269
A	GLU563
A	TRP593
A	ASP595
A	PRO596
A	PRO597
A	HIS642
A	HOH801

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30467178","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30467178","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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