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6I5T

Cryo-EM informed directed evolution of Nitrilase 4 leads to a change in quaternary structure.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000257molecular_functionnitrilase activity
A0003824molecular_functioncatalytic activity
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0016787molecular_functionhydrolase activity
A0016829molecular_functionlyase activity
A0016836molecular_functionhydro-lyase activity
A0018822molecular_functionnitrile hydratase activity
A0019499biological_processcyanide metabolic process
A0047427molecular_functioncyanoalanine nitrilase activity
A0047558molecular_function3-cyanoalanine hydratase activity
A0051410biological_processdetoxification of nitrogen compound
A0080061molecular_functionindole-3-acetonitrile nitrilase activity
B0000257molecular_functionnitrilase activity
B0003824molecular_functioncatalytic activity
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0016787molecular_functionhydrolase activity
B0016829molecular_functionlyase activity
B0016836molecular_functionhydro-lyase activity
B0018822molecular_functionnitrile hydratase activity
B0019499biological_processcyanide metabolic process
B0047427molecular_functioncyanoalanine nitrilase activity
B0047558molecular_function3-cyanoalanine hydratase activity
B0051410biological_processdetoxification of nitrogen compound
B0080061molecular_functionindole-3-acetonitrile nitrilase activity
C0000257molecular_functionnitrilase activity
C0003824molecular_functioncatalytic activity
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0016787molecular_functionhydrolase activity
C0016829molecular_functionlyase activity
C0016836molecular_functionhydro-lyase activity
C0018822molecular_functionnitrile hydratase activity
C0019499biological_processcyanide metabolic process
C0047427molecular_functioncyanoalanine nitrilase activity
C0047558molecular_function3-cyanoalanine hydratase activity
C0051410biological_processdetoxification of nitrogen compound
C0080061molecular_functionindole-3-acetonitrile nitrilase activity
D0000257molecular_functionnitrilase activity
D0003824molecular_functioncatalytic activity
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0016787molecular_functionhydrolase activity
D0016829molecular_functionlyase activity
D0016836molecular_functionhydro-lyase activity
D0018822molecular_functionnitrile hydratase activity
D0019499biological_processcyanide metabolic process
D0047427molecular_functioncyanoalanine nitrilase activity
D0047558molecular_function3-cyanoalanine hydratase activity
D0051410biological_processdetoxification of nitrogen compound
D0080061molecular_functionindole-3-acetonitrile nitrilase activity
E0000257molecular_functionnitrilase activity
E0003824molecular_functioncatalytic activity
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0016787molecular_functionhydrolase activity
E0016829molecular_functionlyase activity
E0016836molecular_functionhydro-lyase activity
E0018822molecular_functionnitrile hydratase activity
E0019499biological_processcyanide metabolic process
E0047427molecular_functioncyanoalanine nitrilase activity
E0047558molecular_function3-cyanoalanine hydratase activity
E0051410biological_processdetoxification of nitrogen compound
E0080061molecular_functionindole-3-acetonitrile nitrilase activity
F0000257molecular_functionnitrilase activity
F0003824molecular_functioncatalytic activity
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0016787molecular_functionhydrolase activity
F0016829molecular_functionlyase activity
F0016836molecular_functionhydro-lyase activity
F0018822molecular_functionnitrile hydratase activity
F0019499biological_processcyanide metabolic process
F0047427molecular_functioncyanoalanine nitrilase activity
F0047558molecular_function3-cyanoalanine hydratase activity
F0051410biological_processdetoxification of nitrogen compound
F0080061molecular_functionindole-3-acetonitrile nitrilase activity
Functional Information from PROSITE/UniProt
site_idPS00920
Number of Residues16
DetailsNITRIL_CHT_1 Nitrilases / cyanide hydratase signature 1. GsqLVvFpEafIgGYP
ChainResidueDetails
FGLY68-PRO83

site_idPS00921
Number of Residues14
DetailsNITRIL_CHT_2 Nitrilases / cyanide hydratase active site signature. GAaiCWENrmPSlR
ChainResidueDetails
FGLY193-ARG206

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00054
ChainResidueDetails
FGLU76
EGLU76
DGLU76
CGLU76
BGLU76
AGLU76

site_idSWS_FT_FI2
Number of Residues6
DetailsACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU00054
ChainResidueDetails
FLYS163
ELYS163
DLYS163
CLYS163
BLYS163
ALYS163

site_idSWS_FT_FI3
Number of Residues6
DetailsACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU00054, ECO:0000255|PROSITE-ProRule:PRU10105
ChainResidueDetails
FCYS197
ECYS197
DCYS197
CCYS197
BCYS197
ACYS197

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: N-acetylserine => ECO:0000250|UniProtKB:P32962
ChainResidueDetails
FSER2
ESER2
DSER2
CSER2
BSER2
ASER2

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PDB entries from 2024-07-17

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