Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HYT

Crystal structure of DHX8 helicase domain bound to ADP at 2.3 Angstrom

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003676	molecular_function	nucleic acid binding
A	0003724	molecular_function	RNA helicase activity
A	0005524	molecular_function	ATP binding
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003676	molecular_function	nucleic acid binding
B	0003724	molecular_function	RNA helicase activity
B	0005524	molecular_function	ATP binding
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003676	molecular_function	nucleic acid binding
C	0003724	molecular_function	RNA helicase activity
C	0005524	molecular_function	ATP binding
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0003676	molecular_function	nucleic acid binding
D	0003724	molecular_function	RNA helicase activity
D	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue ADP A 1301

Chain	Residue
A	THR590
A	PHE825
A	THR847
A	ASP849
A	ARG893
A	MG1302
A	HOH1405
A	HOH1436
A	HOH1455
A	HOH1465
A	GLY591
A	SER592
A	GLY593
A	LYS594
A	THR595
A	THR596
A	SER625
A	ARG629

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 1302

Chain	Residue
A	THR595
A	ADP1301
A	HOH1405
A	HOH1436
A	HOH1465
A	HOH1493

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 1303

Chain	Residue
A	PHE1018
A	LYS1032
A	ASP1041
A	THR1044
A	GLU1164

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 1304

Chain	Residue
A	PRO805
A	SER832
A	HOH1422
A	HOH1433

site_id	AC5
Number of Residues	2
Details	binding site for residue EDO A 1305

Chain	Residue
A	HIS1136
A	ARG1163

site_id	AC6
Number of Residues	2
Details	binding site for residue DMS A 1306

Chain	Residue
A	THR736
A	HOH1411

site_id	AC7
Number of Residues	2
Details	binding site for residue DMS A 1308

Chain	Residue
A	ALA605
A	GLY606

site_id	AC8
Number of Residues	3
Details	binding site for residue ACT A 1309

Chain	Residue
A	THR749
A	THR763
A	ARG901

site_id	AC9
Number of Residues	2
Details	binding site for residue CL A 1310

Chain	Residue
A	TYR568
A	LYS571

site_id	AD1
Number of Residues	18
Details	binding site for residue ADP B 1301

Chain	Residue
B	THR590
B	GLY591
B	SER592
B	GLY593
B	LYS594
B	THR595
B	THR596
B	SER625
B	ARG629
B	PHE825
B	THR847
B	ASP849
B	ARG893
B	MG1302
B	HOH1404
B	HOH1415
B	HOH1427
B	HOH1485

site_id	AD2
Number of Residues	7
Details	binding site for residue MG B 1302

Chain	Residue
B	THR595
B	ASP685
B	ADP1301
B	HOH1404
B	HOH1415
B	HOH1427
B	HOH1492

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO B 1303

Chain	Residue
B	HIS768
B	PRO805
B	HOH1422
C	PRO896

site_id	AD4
Number of Residues	5
Details	binding site for residue EDO B 1304

Chain	Residue
B	TYR742
B	THR894
B	GLY895
C	PRO773
C	ARG833

site_id	AD5
Number of Residues	5
Details	binding site for residue EDO B 1305

Chain	Residue
B	PHE1018
B	LYS1032
B	ASP1041
B	THR1044
B	GLU1164

site_id	AD6
Number of Residues	2
Details	binding site for residue DMS B 1306

Chain	Residue
B	GLN766
B	GLU771

site_id	AD7
Number of Residues	1
Details	binding site for residue DMS B 1307

Chain	Residue
B	ARG1163

site_id	AD8
Number of Residues	1
Details	binding site for residue DMS B 1308

Chain	Residue
B	THR736

site_id	AD9
Number of Residues	1
Details	binding site for residue DMS B 1309

Chain	Residue
B	ASP968

site_id	AE1
Number of Residues	2
Details	binding site for residue DMS B 1310

Chain	Residue
B	ALA605
B	GLY606

site_id	AE2
Number of Residues	1
Details	binding site for residue DMS B 1311

Chain	Residue
B	GLY858

site_id	AE3
Number of Residues	1
Details	binding site for residue DMS B 1312

Chain	Residue
B	GLN1104

site_id	AE4
Number of Residues	2
Details	binding site for residue CL B 1314

Chain	Residue
B	TYR568
B	LYS571

site_id	AE5
Number of Residues	17
Details	binding site for residue ADP C 1301

Chain	Residue
C	THR595
C	THR596
C	SER625
C	ARG629
C	PHE825
C	THR847
C	ASP849
C	MG1302
C	HOH1406
C	HOH1408
C	HOH1430
C	HOH1432
C	THR590
C	GLY591
C	SER592
C	GLY593
C	LYS594

site_id	AE6
Number of Residues	6
Details	binding site for residue MG C 1302

Chain	Residue
C	THR595
C	ADP1301
C	HOH1406
C	HOH1408
C	HOH1430
C	HOH1480

site_id	AE7
Number of Residues	5
Details	binding site for residue EDO C 1303

Chain	Residue
C	THR645
C	ILE646
C	PHE648
C	GLU649
C	MET665

site_id	AE8
Number of Residues	5
Details	binding site for residue EDO C 1304

Chain	Residue
C	PHE1018
C	LYS1032
C	ASP1041
C	THR1044
C	GLU1164

site_id	AE9
Number of Residues	2
Details	binding site for residue DMS C 1306

Chain	Residue
C	PHE735
C	THR736

site_id	AF1
Number of Residues	2
Details	binding site for residue DMS C 1307

Chain	Residue
C	GLN1104
C	TRP1172

site_id	AF2
Number of Residues	5
Details	binding site for residue DMS C 1308

Chain	Residue
C	GLN640
C	CYS651
C	THR652
D	GLU649
D	DMS1305

site_id	AF3
Number of Residues	2
Details	binding site for residue CL C 1309

Chain	Residue
C	TYR568
C	LYS571

site_id	AF4
Number of Residues	20
Details	binding site for residue ADP D 1301

Chain	Residue
D	LEU565
D	THR590
D	GLY591
D	SER592
D	GLY593
D	LYS594
D	THR595
D	THR596
D	SER625
D	ARG629
D	PHE825
D	THR847
D	ASP849
D	ARG893
D	MG1302
D	HOH1407
D	HOH1408
D	HOH1427
D	HOH1443
D	HOH1447

site_id	AF5
Number of Residues	6
Details	binding site for residue MG D 1302

Chain	Residue
D	THR595
D	ADP1301
D	HOH1407
D	HOH1408
D	HOH1447
D	HOH1501

site_id	AF6
Number of Residues	7
Details	binding site for residue EDO D 1303

Chain	Residue
D	PHE1018
D	LYS1032
D	ASP1041
D	THR1044
D	LEU1045
D	ALA1140
D	GLU1164

site_id	AF7
Number of Residues	5
Details	binding site for residue EDO D 1304

Chain	Residue
A	TYR742
A	PRO896
D	PRO773
D	SER832
D	ARG833

site_id	AF8
Number of Residues	4
Details	binding site for residue DMS D 1305

Chain	Residue
C	GLU649
C	DMS1308
D	CYS651
D	THR652

site_id	AF9
Number of Residues	3
Details	binding site for residue DMS D 1306

Chain	Residue
D	GLN766
D	THR770
D	TYR900

site_id	AG1
Number of Residues	2
Details	binding site for residue DMS D 1307

Chain	Residue
D	PHE735
D	THR736

site_id	AG2
Number of Residues	2
Details	binding site for residue DMS D 1308

Chain	Residue
D	HIS1136
D	ARG1163

site_id	AG3
Number of Residues	2
Details	binding site for residue CL D 1309

Chain	Residue
D	TYR568
D	LYS571

Functional Information from PROSITE/UniProt

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AiIMLDEAHE

Chain	Residue	Details
A	ALA680-GLU689

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00541

Chain	Residue	Details
A	GLY588
B	GLY588
C	GLY588
D	GLY588

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)