6GY2
Crystal structure of human Plk1-PBD in complex with WSSSLATPPTLSSpTVLI phosphopeptide from BRCA2
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 701 |
| Chain | Residue |
| A | GLY393 |
| A | LEU394 |
| A | VAL395 |
| A | TYR453 |
| A | SER471 |
| A | LYS475 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for Ligand residues TPO C 207 through VAL C 208 bound to SER C 206 |
| Chain | Residue |
| B | HIS538 |
| B | LYS540 |
| C | SER206 |
| C | LEU209 |
| C | HOH301 |
| B | HIS489 |
| B | LEU490 |
| B | LEU491 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for Ligand residues TPO D 207 through VAL D 208 bound to SER D 206 |
| Chain | Residue |
| A | HIS489 |
| A | LEU490 |
| A | LEU491 |
| A | HIS538 |
| A | LYS540 |
| A | HOH801 |
| D | SER206 |
| D | LEU209 |
| D | HOH301 |
| D | HOH302 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| A | SER375 | |
| A | SER450 | |
| B | SER375 | |
| B | SER450 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| A | THR498 | |
| B | THR498 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23455478 |
| Chain | Residue | Details |
| A | LYS492 | |
| B | LYS492 |
