6GY2
Crystal structure of human Plk1-PBD in complex with WSSSLATPPTLSSpTVLI phosphopeptide from BRCA2
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 701 |
| Chain | Residue |
| A | GLY393 |
| A | LEU394 |
| A | VAL395 |
| A | TYR453 |
| A | SER471 |
| A | LYS475 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for Ligand residues TPO C 207 through VAL C 208 bound to SER C 206 |
| Chain | Residue |
| B | HIS538 |
| B | LYS540 |
| C | SER206 |
| C | LEU209 |
| C | HOH301 |
| B | HIS489 |
| B | LEU490 |
| B | LEU491 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for Ligand residues TPO D 207 through VAL D 208 bound to SER D 206 |
| Chain | Residue |
| A | HIS489 |
| A | LEU490 |
| A | LEU491 |
| A | HIS538 |
| A | LYS540 |
| A | HOH801 |
| D | SER206 |
| D | LEU209 |
| D | HOH301 |
| D | HOH302 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 156 |
| Details | Domain: {"description":"POLO box 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 164 |
| Details | Domain: {"description":"POLO box 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | Region: {"description":"Linker"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Region: {"description":"Important for interaction with phosphorylated proteins","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23455478","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
