6FC1
Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae in the cap-bound state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003743 | molecular_function | translation initiation factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006413 | biological_process | translational initiation |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003743 | molecular_function | translation initiation factor activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006413 | biological_process | translational initiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue MGP A 301 |
| Chain | Residue |
| A | TRP58 |
| A | HOH436 |
| A | HOH444 |
| A | HOH490 |
| A | HOH509 |
| A | HOH512 |
| A | LYS90 |
| A | GLU103 |
| A | TRP104 |
| A | GLU105 |
| A | ARG157 |
| A | LYS162 |
| A | HOH424 |
| A | HOH425 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | LYS111 |
| A | HOH401 |
| A | HOH437 |
| C | LEU89 |
| C | GLY121 |
| C | ARG157 |
| C | ASN161 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 201 |
| Chain | Residue |
| B | ARG146 |
| B | HOH338 |
| B | HOH352 |
| C | ASN40 |
| D | TYR104 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue MGP C 301 |
| Chain | Residue |
| C | TRP58 |
| C | GLU103 |
| C | TRP104 |
| C | GLU105 |
| C | ARG157 |
| C | LYS162 |
| C | HOH403 |
| C | HOH419 |
| C | HOH450 |
| C | HOH463 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 302 |
| Chain | Residue |
| B | LYS141 |
| B | LYS143 |
| C | ASP146 |
| C | SER147 |
| C | GLN148 |
| C | HOH401 |
| C | HOH506 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 303 |
| Chain | Residue |
| B | GLU134 |
| C | GLU144 |
| C | ASP145 |
| C | ARG177 |
| C | LYS181 |
| C | HOH444 |
| C | HOH536 |
| D | TYR97 |
| D | PRO99 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 304 |
| Chain | Residue |
| C | GLU170 |
| C | SER210 |
| C | HOH445 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 201 |
| Chain | Residue |
| B | ASP129 |
| D | PRO93 |
| D | TYR97 |
| D | HOH314 |
Functional Information from PROSITE/UniProt
| site_id | PS00813 |
| Number of Residues | 24 |
| Details | IF4E Eukaryotic initiation factor 4E signature. DYhvFRndVrPeWEDeanakGGKW |
| Chain | Residue | Details |
| A | ASP92-TRP115 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
