6DXW

Human N-acylethanolamine-hydrolyzing acid amidase (NAAA) precursor (C126A)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0006631	biological_process	fatty acid metabolic process
A	0006670	biological_process	sphingosine metabolic process
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0017040	molecular_function	N-acylsphingosine amidohydrolase activity
A	0017064	molecular_function	fatty acid amide hydrolase activity
A	0043202	cellular_component	lysosomal lumen
A	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
A	0070062	cellular_component	extracellular exosome
A	0070291	biological_process	N-acylethanolamine metabolic process
A	0070292	biological_process	N-acylphosphatidylethanolamine metabolic process
A	0102121	molecular_function	ceramidase activity
A	0140297	molecular_function	DNA-binding transcription factor binding
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0006631	biological_process	fatty acid metabolic process
B	0006670	biological_process	sphingosine metabolic process
B	0016020	cellular_component	membrane
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B	0017040	molecular_function	N-acylsphingosine amidohydrolase activity
B	0017064	molecular_function	fatty acid amide hydrolase activity
B	0043202	cellular_component	lysosomal lumen
B	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
B	0070062	cellular_component	extracellular exosome
B	0070291	biological_process	N-acylethanolamine metabolic process
B	0070292	biological_process	N-acylphosphatidylethanolamine metabolic process
B	0102121	molecular_function	ceramidase activity
B	0140297	molecular_function	DNA-binding transcription factor binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0006631	biological_process	fatty acid metabolic process
C	0006670	biological_process	sphingosine metabolic process
C	0016020	cellular_component	membrane
C	0016042	biological_process	lipid catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
C	0017040	molecular_function	N-acylsphingosine amidohydrolase activity
C	0017064	molecular_function	fatty acid amide hydrolase activity
C	0043202	cellular_component	lysosomal lumen
C	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
C	0070062	cellular_component	extracellular exosome
C	0070291	biological_process	N-acylethanolamine metabolic process
C	0070292	biological_process	N-acylphosphatidylethanolamine metabolic process
C	0102121	molecular_function	ceramidase activity
C	0140297	molecular_function	DNA-binding transcription factor binding
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0006631	biological_process	fatty acid metabolic process
D	0006670	biological_process	sphingosine metabolic process
D	0016020	cellular_component	membrane
D	0016042	biological_process	lipid catabolic process
D	0016787	molecular_function	hydrolase activity
D	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
D	0017040	molecular_function	N-acylsphingosine amidohydrolase activity
D	0017064	molecular_function	fatty acid amide hydrolase activity
D	0043202	cellular_component	lysosomal lumen
D	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
D	0070062	cellular_component	extracellular exosome
D	0070291	biological_process	N-acylethanolamine metabolic process
D	0070292	biological_process	N-acylphosphatidylethanolamine metabolic process
D	0102121	molecular_function	ceramidase activity
D	0140297	molecular_function	DNA-binding transcription factor binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:17980170, ECO:0000269|PubMed:18793752, ECO:0000269|PubMed:30301806, ECO:0000305|PubMed:22040171

Chain	Residue	Details
A	ALA126
B	ALA126
C	ALA126
D	ALA126

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site_id	SWS_FT_FI2
Number of Residues	8
Details	SITE: Important for enzyme activity => ECO:0000269|PubMed:18793752, ECO:0000305|PubMed:30301806

Chain	Residue	Details
A	ARG142
A	ASN287
B	ARG142
B	ASN287
C	ARG142
C	ASN287
D	ARG142
D	ASN287

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22040171, ECO:0000269|PubMed:30301806, ECO:0007744|PDB:6DXW, ECO:0007744|PDB:6DXX

Chain	Residue	Details
A	ASN37
B	ASN37
C	ASN37
D	ASN37

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22040171, ECO:0000269|PubMed:30301806, ECO:0007744|PDB:6DXX

Chain	Residue	Details
A	ASN107
B	ASN107
C	ASN107
D	ASN107

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site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17980170, ECO:0000269|PubMed:22040171, ECO:0000269|PubMed:30301806, ECO:0007744|PDB:6DXW, ECO:0007744|PDB:6DXX

Chain	Residue	Details
A	ASN309
B	ASN309
C	ASN309
D	ASN309

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site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17980170, ECO:0000269|PubMed:22040171, ECO:0000269|PubMed:30301806, ECO:0007744|PDB:6DXW

Chain	Residue	Details
A	ASN333
B	ASN333
C	ASN333
D	ASN333

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