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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6DXW

Human N-acylethanolamine-hydrolyzing acid amidase (NAAA) precursor (C126A)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006670biological_processsphingosine metabolic process
A0016020cellular_componentmembrane
A0016042biological_processlipid catabolic process
A0016787molecular_functionhydrolase activity
A0016810molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A0017040molecular_functionN-acylsphingosine amidohydrolase activity
A0017064molecular_functionfatty acid amide hydrolase activity
A0043202cellular_componentlysosomal lumen
A0047412molecular_functionN-(long-chain-acyl)ethanolamine deacylase activity
A0070062cellular_componentextracellular exosome
A0070291biological_processN-acylethanolamine metabolic process
A0070292biological_processN-acylphosphatidylethanolamine metabolic process
A0140297molecular_functionDNA-binding transcription factor binding
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0006670biological_processsphingosine metabolic process
B0016020cellular_componentmembrane
B0016042biological_processlipid catabolic process
B0016787molecular_functionhydrolase activity
B0016810molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B0017040molecular_functionN-acylsphingosine amidohydrolase activity
B0017064molecular_functionfatty acid amide hydrolase activity
B0043202cellular_componentlysosomal lumen
B0047412molecular_functionN-(long-chain-acyl)ethanolamine deacylase activity
B0070062cellular_componentextracellular exosome
B0070291biological_processN-acylethanolamine metabolic process
B0070292biological_processN-acylphosphatidylethanolamine metabolic process
B0140297molecular_functionDNA-binding transcription factor binding
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0006629biological_processlipid metabolic process
C0006631biological_processfatty acid metabolic process
C0006670biological_processsphingosine metabolic process
C0016020cellular_componentmembrane
C0016042biological_processlipid catabolic process
C0016787molecular_functionhydrolase activity
C0016810molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
C0017040molecular_functionN-acylsphingosine amidohydrolase activity
C0017064molecular_functionfatty acid amide hydrolase activity
C0043202cellular_componentlysosomal lumen
C0047412molecular_functionN-(long-chain-acyl)ethanolamine deacylase activity
C0070062cellular_componentextracellular exosome
C0070291biological_processN-acylethanolamine metabolic process
C0070292biological_processN-acylphosphatidylethanolamine metabolic process
C0140297molecular_functionDNA-binding transcription factor binding
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0006629biological_processlipid metabolic process
D0006631biological_processfatty acid metabolic process
D0006670biological_processsphingosine metabolic process
D0016020cellular_componentmembrane
D0016042biological_processlipid catabolic process
D0016787molecular_functionhydrolase activity
D0016810molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
D0017040molecular_functionN-acylsphingosine amidohydrolase activity
D0017064molecular_functionfatty acid amide hydrolase activity
D0043202cellular_componentlysosomal lumen
D0047412molecular_functionN-(long-chain-acyl)ethanolamine deacylase activity
D0070062cellular_componentextracellular exosome
D0070291biological_processN-acylethanolamine metabolic process
D0070292biological_processN-acylphosphatidylethanolamine metabolic process
D0140297molecular_functionDNA-binding transcription factor binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"17980170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18793752","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30301806","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22040171","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsSite: {"description":"Important for enzyme activity","evidences":[{"source":"PubMed","id":"18793752","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30301806","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22040171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30301806","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DXX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22040171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30301806","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DXX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17980170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22040171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30301806","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DXX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17980170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22040171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30301806","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DXW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2026-01-14

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