6DCA
Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 L 301 |
| Chain | Residue |
| H | SER97 |
| L | LYS30 |
| L | TYR32 |
| P | THR403 |
| P | SER404 |
| P | HOH501 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 M 301 |
| Chain | Residue |
| M | TYR32 |
| Q | SER404 |
| I | ASP96 |
| I | SER97 |
| M | LYS30 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 R 501 |
| Chain | Residue |
| J | SER97 |
| J | HOH323 |
| N | LYS30 |
| N | TYR32 |
| R | THR403 |
| R | SER404 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 S 501 |
| Chain | Residue |
| K | SER97 |
| O | LYS30 |
| O | TYR32 |
| S | SER404 |
| S | HOH601 |
| S | HOH602 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide LEU Q 408 and NH2 Q 409 |
| Chain | Residue |
| I | THR33 |
| I | HIS35 |
| I | GLY95 |
| I | ASP96 |
| I | TRP99 |
| M | TYR32 |
| M | GLY91 |
| M | LEU96 |
| Q | PRO405 |
| Q | ARG406 |
| Q | HIS407 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide LEU R 408 and NH2 R 409 |
| Chain | Residue |
| J | THR33 |
| J | HIS35 |
| J | GLY95 |
| J | ASP96 |
| J | TRP99 |
| N | TYR32 |
| N | GLY91 |
| R | PRO405 |
| R | ARG406 |
| R | HIS407 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide LEU S 408 and NH2 S 409 |
| Chain | Residue |
| K | THR33 |
| K | HIS35 |
| K | GLY95 |
| K | ASP96 |
| K | TRP99 |
| O | TYR32 |
| O | GLY91 |
| S | PRO405 |
| S | ARG406 |
| S | HIS407 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by CK1 and PDPK1","evidences":[{"source":"PubMed","id":"14761950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15546861","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19451179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21327254","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9614189","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15546861","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
