6DCA
Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 L 301 |
| Chain | Residue |
| H | SER97 |
| L | LYS30 |
| L | TYR32 |
| P | THR403 |
| P | SER404 |
| P | HOH501 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 M 301 |
| Chain | Residue |
| M | TYR32 |
| Q | SER404 |
| I | ASP96 |
| I | SER97 |
| M | LYS30 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 R 501 |
| Chain | Residue |
| J | SER97 |
| J | HOH323 |
| N | LYS30 |
| N | TYR32 |
| R | THR403 |
| R | SER404 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 S 501 |
| Chain | Residue |
| K | SER97 |
| O | LYS30 |
| O | TYR32 |
| S | SER404 |
| S | HOH601 |
| S | HOH602 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide LEU Q 408 and NH2 Q 409 |
| Chain | Residue |
| I | THR33 |
| I | HIS35 |
| I | GLY95 |
| I | ASP96 |
| I | TRP99 |
| M | TYR32 |
| M | GLY91 |
| M | LEU96 |
| Q | PRO405 |
| Q | ARG406 |
| Q | HIS407 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide LEU R 408 and NH2 R 409 |
| Chain | Residue |
| J | THR33 |
| J | HIS35 |
| J | GLY95 |
| J | ASP96 |
| J | TRP99 |
| N | TYR32 |
| N | GLY91 |
| R | PRO405 |
| R | ARG406 |
| R | HIS407 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide LEU S 408 and NH2 S 409 |
| Chain | Residue |
| K | THR33 |
| K | HIS35 |
| K | GLY95 |
| K | ASP96 |
| K | TRP99 |
| O | TYR32 |
| O | GLY91 |
| S | PRO405 |
| S | ARG406 |
| S | HIS407 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:9326300 |
| Chain | Residue | Details |
| P | LYS383 | |
| S | LYS383 | |
| S | LYS385 | |
| S | LYS395 | |
| P | LYS385 | |
| P | LYS395 | |
| Q | LYS383 | |
| Q | LYS385 | |
| Q | LYS395 | |
| R | LYS383 | |
| R | LYS385 | |
| R | LYS395 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| P | LYS385 | |
| Q | LYS385 | |
| R | LYS385 | |
| S | LYS385 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| P | TYR394 | |
| Q | TYR394 | |
| R | TYR394 | |
| S | TYR394 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| P | SER396 | |
| Q | SER396 | |
| R | SER396 | |
| S | SER396 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; alternate => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| P | SER400 | |
| Q | SER400 | |
| R | SER400 | |
| S | SER400 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| P | THR403 | |
| Q | THR403 | |
| R | THR403 | |
| S | THR403 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| P | SER404 | |
| Q | SER404 | |
| R | SER404 | |
| S | SER404 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000269|PubMed:21327254 |
| Chain | Residue | Details |
| P | SER400 | |
| Q | SER400 | |
| R | SER400 | |
| S | SER400 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| P | LYS385 | |
| Q | LYS385 | |
| R | LYS385 | |
| S | LYS385 |
