6C7I
Crystal structure of human phosphodiesterase 2A with 1-(2-chloro-5-methoxy-phenyl)-N-isobutyl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| C | 0007165 | biological_process | signal transduction |
| C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| D | 0007165 | biological_process | signal transduction |
| D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue EP7 A 1001 |
| Chain | Residue |
| A | THR768 |
| A | HOH1119 |
| A | HOH1128 |
| A | HOH1142 |
| A | HOH1219 |
| A | HOH1237 |
| A | HOH1270 |
| D | LYS584 |
| A | LEU770 |
| A | ASP808 |
| A | LEU809 |
| A | GLN812 |
| A | ILE826 |
| A | PHE830 |
| A | GLN859 |
| A | PHE862 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 1002 |
| Chain | Residue |
| A | HIS660 |
| A | HIS696 |
| A | ASP697 |
| A | ASP808 |
| A | HOH1136 |
| A | HOH1249 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1003 |
| Chain | Residue |
| A | ASP697 |
| A | HOH1134 |
| A | HOH1136 |
| A | HOH1176 |
| A | HOH1191 |
| A | HOH1265 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | binding site for residue EP7 B 1001 |
| Chain | Residue |
| B | HIS656 |
| B | THR768 |
| B | LEU770 |
| B | ASP808 |
| B | LEU809 |
| B | GLN812 |
| B | ILE826 |
| B | PHE830 |
| B | GLN859 |
| B | PHE862 |
| B | ILE866 |
| B | HOH1106 |
| B | HOH1149 |
| B | HOH1151 |
| B | HOH1225 |
| B | HOH1248 |
| B | HOH1264 |
| B | HOH1343 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 1002 |
| Chain | Residue |
| B | HIS660 |
| B | HIS696 |
| B | ASP697 |
| B | ASP808 |
| B | HOH1110 |
| B | HOH1254 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 1003 |
| Chain | Residue |
| B | ASP697 |
| B | HOH1110 |
| B | HOH1119 |
| B | HOH1154 |
| B | HOH1165 |
| B | HOH1260 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residue EP7 C 1001 |
| Chain | Residue |
| C | THR768 |
| C | LEU770 |
| C | ASP808 |
| C | GLN812 |
| C | ILE826 |
| C | PHE830 |
| C | PHE862 |
| C | HOH1113 |
| C | HOH1120 |
| C | HOH1169 |
| C | HOH1199 |
| C | HOH1222 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue ZN C 1002 |
| Chain | Residue |
| C | HIS660 |
| C | HIS696 |
| C | ASP697 |
| C | ASP808 |
| C | HOH1103 |
| C | HOH1193 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 1003 |
| Chain | Residue |
| C | ASP697 |
| C | HOH1103 |
| C | HOH1134 |
| C | HOH1147 |
| C | HOH1192 |
| C | HOH1246 |
| site_id | AD1 |
| Number of Residues | 15 |
| Details | binding site for residue EP7 D 1001 |
| Chain | Residue |
| A | ASP588 |
| A | GLN591 |
| D | THR768 |
| D | LEU770 |
| D | ASP808 |
| D | LEU809 |
| D | GLN812 |
| D | ILE826 |
| D | PHE830 |
| D | PHE862 |
| D | HOH1118 |
| D | HOH1175 |
| D | HOH1223 |
| D | HOH1253 |
| D | HOH1294 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN D 1002 |
| Chain | Residue |
| D | ASP697 |
| D | ASP808 |
| D | HOH1144 |
| D | HOH1184 |
| D | HIS660 |
| D | HIS696 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 1003 |
| Chain | Residue |
| D | ASP697 |
| D | HOH1140 |
| D | HOH1144 |
| D | HOH1168 |
| D | HOH1169 |
| D | HOH1251 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGtnNsF |
| Chain | Residue | Details |
| A | HIS696-PHE707 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083 |
| Chain | Residue | Details |
| A | SER912 | |
| B | SER912 | |
| C | SER912 | |
| D | SER912 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q922S4 |
| Chain | Residue | Details |
| A | PHE687 | |
| B | GLN755 | |
| C | PHE687 | |
| C | GLY702 | |
| C | SER721 | |
| C | ASN744 | |
| C | GLN755 | |
| D | PHE687 | |
| D | GLY702 | |
| D | SER721 | |
| D | ASN744 | |
| A | GLY702 | |
| D | GLN755 | |
| A | SER721 | |
| A | ASN744 | |
| A | GLN755 | |
| B | PHE687 | |
| B | GLY702 | |
| B | SER721 | |
| B | ASN744 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15938621, ECO:0000269|PubMed:19828435, ECO:0000269|PubMed:23899287, ECO:0007744|PDB:1Z1L, ECO:0007744|PDB:3IBJ, ECO:0007744|PDB:3ITM, ECO:0007744|PDB:3ITU, ECO:0007744|PDB:4HTX, ECO:0007744|PDB:4HTZ, ECO:0007744|PDB:4JIB |
| Chain | Residue | Details |
| A | LEU916 | |
| B | LEU916 | |
| C | LEU916 | |
| D | LEU916 |
