6BDZ

ADAM10 Extracellular Domain Bound by the 11G2 Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TFAHEVGHNF

Chain	Residue	Details
A	THR380-PHE389

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR215-HIS221

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	236
Details	Domain: {"description":"Peptidase M12B","evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	94
Details	Domain: {"description":"Disintegrin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00068","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"29224781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29430990","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24055016","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29224781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37516108","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ESV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29224781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37516108","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ESV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29224781","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BE6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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