6BDZ

ADAM10 Extracellular Domain Bound by the 11G2 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	L	11G2 Fab Light Chain	polymer	215	23455.9	1		Mus musculus
2	H	11G2 Fab Heavy Chain	polymer	226	24097.1	1		Mus musculus
3	A	Disintegrin and metalloproteinase domain-containing protein 10	polymer	443	48943.7	1	UniProt (O14672) Pfam (PF13574) Pfam (PF00200) Pfam (PF21299) In PDB	Homo sapiens (Human)	ADAM 10,CDw156,Kuzbanian protein homolog,Mammalian disintegrin-metalloprotease
4	B	alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G04854NQ)
5	C	alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G62182OO)
6	L	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
7	A	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
8	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
9		water	water		18.0	1	Chemie (HOH)

Sequence modifications

A: 220 - 654 (UniProt: O14672)

PDB	External Database	Details
Gln 267	Asn 267	conflict
Gln 439	Asn 439	conflict
Gln 551	Asn 551	conflict
Gly 655	-	expression tag
Gly 656	-	expression tag
His 657	-	expression tag
His 658	-	expression tag
His 659	-	expression tag
His 660	-	expression tag
His 661	-	expression tag
His 662	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	96496.8
Branched	Number of molecules	2
	Total formula weight	1335.2
Non-Polymers*	Number of molecules	4
	Total formula weight	297.6
All*	Total formula weight	98129.6

*Water molecules are not included.