Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6B67

Human PP2Calpha (PPM1A) complexed with cyclic peptide c(MpSIpYVA)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	0043169	molecular_function	cation binding
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0006470	biological_process	protein dephosphorylation
B	0043169	molecular_function	cation binding
C	0004722	molecular_function	protein serine/threonine phosphatase activity
C	0006470	biological_process	protein dephosphorylation
C	0043169	molecular_function	cation binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 301

Chain	Residue
A	ASP60
A	GLY61
A	HOH405
A	HOH424
D	SEP2
D	HOH101

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 302

Chain	Residue
A	HOH405
A	HOH453
A	HOH510
A	ASP60
A	ASP239
A	ASP282

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 303

Chain	Residue
A	ASP239
A	ASP243
A	HOH504
A	HOH581
A	HOH584
D	HOH105

site_id	AC4
Number of Residues	5
Details	binding site for residue CA A 304

Chain	Residue
A	GLU265
A	HOH416
A	HOH568
B	GLN16
B	GLU265

site_id	AC5
Number of Residues	6
Details	binding site for residue CA B 301

Chain	Residue
B	ASP60
B	GLY61
B	HOH406
B	HOH438
E	SEP2
E	HOH101

site_id	AC6
Number of Residues	8
Details	binding site for residue CA B 302

Chain	Residue
B	ASP60
B	ASP239
B	ASP282
B	HOH406
B	HOH414
B	HOH441
B	HOH469
E	SEP2

site_id	AC7
Number of Residues	5
Details	binding site for residue CA B 303

Chain	Residue
B	ASP239
B	ASP243
B	HOH549
B	HOH578
E	HOH112

site_id	AC8
Number of Residues	6
Details	binding site for residue CA C 301

Chain	Residue
C	ASP60
C	GLY61
C	HOH413
F	SEP2
F	HOH101
F	HOH102

site_id	AC9
Number of Residues	8
Details	binding site for residue CA C 302

Chain	Residue
C	ASP60
C	ASP239
C	ASP282
C	HOH407
C	HOH467
C	HOH511
F	SEP2
F	HOH101

site_id	AD1
Number of Residues	4
Details	binding site for residue CA C 303

Chain	Residue
C	ASP239
C	ASP243
C	HOH411
C	HOH573

site_id	AD2
Number of Residues	11
Details	binding site for Di-peptide MET D 1 and 48V D 7

Chain	Residue
A	ARG186
A	ALA192
A	ARG281
C	TYR277
C	HOH478
D	SEP2
D	ILE3
D	PTR4
D	VAL5
D	ALA6
D	HOH105

site_id	AD3
Number of Residues	16
Details	binding site for Di-peptide MET D 1 and SEP D 2

Chain	Residue
A	ARG33
A	ASP60
A	GLY61
A	HIS62
A	ARG186
A	SER190
A	LEU191
A	ALA192
A	CA301
A	HOH405
A	HOH425
A	HOH453
D	ILE3
D	PTR4
D	48V7
D	HOH101

site_id	AD4
Number of Residues	19
Details	binding site for Di-peptide SEP D 2 and ILE D 3

Chain	Residue
A	HOH453
D	MET1
D	PTR4
D	VAL5
D	HOH101
D	HOH104
D	HOH106
A	ARG33
A	ASP60
A	GLY61
A	HIS62
A	ALA63
A	ARG186
A	SER190
A	LEU191
A	ALA192
A	CA301
A	HOH405
A	HOH425

site_id	AD5
Number of Residues	11
Details	binding site for Di-peptide ILE D 3 and PTR D 4

Chain	Residue
A	GLY2
A	ALA3
A	ALA63
A	ARG186
D	MET1
D	SEP2
D	VAL5
D	ALA6
D	HOH102
D	HOH104
D	HOH106

site_id	AD6
Number of Residues	12
Details	binding site for Di-peptide PTR D 4 and VAL D 5

Chain	Residue
A	GLY2
A	ALA3
A	ARG186
C	ARG257
C	GLU270
C	HOH451
D	MET1
D	ILE3
D	ALA6
D	48V7
D	HOH102
D	HOH104

site_id	AD7
Number of Residues	11
Details	binding site for Di-peptide ALA D 6 and 48V D 7

Chain	Residue
A	ARG186
A	ARG281
C	ASP273
C	THR274
C	TYR277
C	HOH478
D	MET1
D	PTR4
D	VAL5
D	HOH103
D	HOH105

site_id	AD8
Number of Residues	14
Details	binding site for Di-peptide MET E 1 and 48V E 7

Chain	Residue
A	TYR277
B	ARG33
B	ARG186
B	ALA192
B	ARG281
B	ASP282
E	SEP2
E	ILE3
E	PTR4
E	VAL5
E	ALA6
E	HOH104
E	HOH106
E	HOH108

site_id	AD9
Number of Residues	18
Details	binding site for Di-peptide MET E 1 and SEP E 2

Chain	Residue
B	ARG33
B	ASP60
B	GLY61
B	HIS62
B	ARG186
B	SER190
B	LEU191
B	ALA192
B	ASP282
B	CA301
B	CA302
B	HOH406
B	HOH523
E	ILE3
E	PTR4
E	48V7
E	HOH101
E	HOH102

site_id	AE1
Number of Residues	20
Details	binding site for Di-peptide SEP E 2 and ILE E 3

Chain	Residue
B	ARG33
B	ASP60
B	GLY61
B	HIS62
B	ALA63
B	ARG186
B	SER190
B	LEU191
B	ALA192
B	CA301
B	CA302
B	HOH406
B	HOH523
E	MET1
E	PTR4
E	VAL5
E	HOH101
E	HOH102
E	HOH103
E	HOH107

site_id	AE2
Number of Residues	13
Details	binding site for Di-peptide ILE E 3 and PTR E 4

Chain	Residue
A	LYS266
B	GLY2
B	ALA3
B	ALA63
B	ARG186
B	HOH433
E	MET1
E	SEP2
E	VAL5
E	ALA6
E	HOH103
E	HOH107
E	HOH109

site_id	AE3
Number of Residues	13
Details	binding site for Di-peptide PTR E 4 and VAL E 5

Chain	Residue
A	ARG257
A	LYS266
A	HOH410
B	GLY2
B	ALA3
B	ARG186
B	HOH433
E	MET1
E	ILE3
E	ALA6
E	48V7
E	HOH107
E	HOH109

site_id	AE4
Number of Residues	12
Details	binding site for Di-peptide ALA E 6 and 48V E 7

Chain	Residue
A	ASP273
A	THR274
A	TYR277
B	ARG186
B	ARG281
E	MET1
E	PTR4
E	VAL5
E	HOH104
E	HOH105
E	HOH106
E	HOH108

site_id	AE5
Number of Residues	19
Details	binding site for Di-peptide MET F 1 and SEP F 2

Chain	Residue
C	ARG33
C	ASP60
C	GLY61
C	HIS62
C	ARG186
C	LEU191
C	ALA192
C	ARG281
C	CA301
C	CA302
C	HOH407
C	HOH434
C	HOH457
C	HOH511
F	ILE3
F	PTR4
F	48V7
F	HOH101
F	HOH102

site_id	AE6
Number of Residues	9
Details	binding site for Di-peptide MET F 1 and 48V F 7

Chain	Residue
C	ARG33
C	ARG186
C	ALA192
C	ARG281
F	SEP2
F	ILE3
F	PTR4
F	VAL5
F	ALA6

site_id	AE7
Number of Residues	18
Details	binding site for Di-peptide SEP F 2 and ILE F 3

Chain	Residue
C	ARG33
C	ASP60
C	GLY61
C	HIS62
C	ARG186
C	SER190
C	LEU191
C	ALA192
C	CA301
C	CA302
C	HOH407
C	HOH434
C	HOH457
C	HOH511
F	MET1
F	PTR4
F	HOH101
F	HOH102

site_id	AE8
Number of Residues	7
Details	binding site for Di-peptide ILE F 3 and PTR F 4

Chain	Residue
C	ARG186
C	SER190
C	LEU191
F	MET1
F	SEP2
F	VAL5
F	ALA6

site_id	AE9
Number of Residues	5
Details	binding site for Di-peptide PTR F 4 and VAL F 5

Chain	Residue
C	ARG186
F	MET1
F	ILE3
F	ALA6
F	48V7

site_id	AF1
Number of Residues	4
Details	binding site for Di-peptide ALA F 6 and 48V F 7

Chain	Residue
C	ARG281
F	MET1
F	PTR4
F	VAL5

Functional Information from PROSITE/UniProt

site_id	PS01032
Number of Residues	9
Details	PPM_1 PPM-type phosphatase domain signature. FFAVYDGHA

Chain	Residue	Details
A	PHE55-ALA63

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	804
Details	Domain: {"description":"PPM-type phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01082","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9003755","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A6Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Lipidation: {"description":"N-myristoyl glycine","evidences":[{"source":"PubMed","id":"20213681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)