5ZLN
Crystal structure of mouse TLR9 in complex with two DNAs (CpG DNA and TCGCCA DNA)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001817 | biological_process | regulation of cytokine production |
| A | 0002237 | biological_process | response to molecule of bacterial origin |
| A | 0002755 | biological_process | MyD88-dependent toll-like receptor signaling pathway |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0016021 | cellular_component | integral component of membrane |
| A | 0034162 | biological_process | toll-like receptor 9 signaling pathway |
| A | 0045087 | biological_process | innate immune response |
| A | 0050729 | biological_process | positive regulation of inflammatory response |
| B | 0001817 | biological_process | regulation of cytokine production |
| B | 0002237 | biological_process | response to molecule of bacterial origin |
| B | 0002755 | biological_process | MyD88-dependent toll-like receptor signaling pathway |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0016021 | cellular_component | integral component of membrane |
| B | 0034162 | biological_process | toll-like receptor 9 signaling pathway |
| B | 0045087 | biological_process | innate immune response |
| B | 0050729 | biological_process | positive regulation of inflammatory response |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 50 |
| Details | Repeat: {"description":"LRR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"LRR 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"LRR 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 50 |
| Details | Repeat: {"description":"LRR 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 48 |
| Details | Repeat: {"description":"LRR 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 13"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 48 |
| Details | Repeat: {"description":"LRR 15"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 16"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 17"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 54 |
| Details | Repeat: {"description":"LRR 18"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 48 |
| Details | Repeat: {"description":"LRR 19"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"LRR 20"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 21"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 22"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 23"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"LRR 24"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 25"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 26"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 54 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q2EEY0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 4 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"Q9NR96","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 30 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI29 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25686612","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3WPF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI30 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25686612","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3WPF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WPH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI31 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25686612","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3WPF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WPH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WPI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
