Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5ZG3

Crystal structure of the GluA2o LBD in complex with glutamate and TAK-137

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
F	0015276	molecular_function	ligand-gated monoatomic ion channel activity
F	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 9C6 A 1001

Chain	Residue
A	ILE502
B	LYS751
B	ASN775
A	PRO515
A	PHE516
A	SER750
A	LYS751
A	GLY752
B	LYS514
B	PRO515
B	SER750

site_id	AC2
Number of Residues	14
Details	binding site for residue GLU A 1002

Chain	Residue
A	TYR471
A	PRO499
A	LEU500
A	THR501
A	ARG506
A	LEU671
A	GLY674
A	SER675
A	THR676
A	GLU726
A	TYR753
A	HOH1116
A	HOH1134
A	HOH1148

site_id	AC3
Number of Residues	13
Details	binding site for residue GLU B 901

Chain	Residue
B	TYR471
B	PRO499
B	LEU500
B	THR501
B	ARG506
B	GLY674
B	SER675
B	THR676
B	GLU726
B	TYR753
B	HOH1006
B	HOH1014
B	HOH1027

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 902

Chain	Residue
B	GLU452
B	LYS455
B	HIS456
B	GLN777

site_id	AC5
Number of Residues	3
Details	binding site for residue ACT B 903

Chain	Residue
B	GLU443
B	LYS786
B	HOH1060

site_id	AC6
Number of Residues	5
Details	binding site for residue ACT B 904

Chain	Residue
B	ALA473
B	ASP475
B	ASN482
B	SER673
B	HOH1040

site_id	AC7
Number of Residues	2
Details	binding site for residue ZN B 905

Chain	Residue
B	HIS456
B	HOH1154

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN C 801

Chain	Residue
A	GLU452
A	HIS456
C	GLU699
C	HOH1085

site_id	AC9
Number of Residues	14
Details	binding site for residue GLU C 802

Chain	Residue
C	TYR471
C	PRO499
C	LEU500
C	THR501
C	ARG506
C	LEU671
C	GLY674
C	SER675
C	THR676
C	GLU726
C	TYR753
C	HOH935
C	HOH956
C	HOH958

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN C 803

Chain	Residue
C	GLU452
C	HIS456
C	LEU774
C	HOH1082

site_id	AD2
Number of Residues	3
Details	binding site for residue ACT C 804

Chain	Residue
C	ARG713
C	SER717
C	LYS720

site_id	AD3
Number of Residues	5
Details	binding site for residue ACT C 805

Chain	Residue
C	ASP781
C	HOH1063
D	ASN747
D	ASP749
D	SER750

site_id	AD4
Number of Residues	6
Details	binding site for residue ACT C 806

Chain	Residue
C	ASN747
C	LEU748
C	ASP749
C	SER750
C	HOH1078
D	ASP781

site_id	AD5
Number of Residues	1
Details	binding site for residue ZN D 801

Chain	Residue
D	ASP689

site_id	AD6
Number of Residues	24
Details	binding site for residue 9C6 D 802

Chain	Residue
C	HOH1077
D	ILE502
D	PRO515
D	PHE516
D	MET517
D	SER518
D	SER750
D	LYS751
D	GLY752
D	ASN775
D	HOH901
D	HOH902
D	HOH1048
D	HOH1073
C	ILE502
C	PRO515
C	PHE516
C	MET517
C	SER518
C	SER750
C	LYS751
C	GLY752
C	ASN775
C	HOH1053

site_id	AD7
Number of Residues	14
Details	binding site for residue GLU D 803

Chain	Residue
D	TYR471
D	PRO499
D	LEU500
D	THR501
D	ARG506
D	LEU671
D	GLY674
D	SER675
D	THR676
D	GLU726
D	TYR753
D	HOH934
D	HOH979
D	HOH983

site_id	AD8
Number of Residues	3
Details	binding site for residue ZN D 804

Chain	Residue
D	HIS433
D	GLU440
D	ACT807

site_id	AD9
Number of Residues	3
Details	binding site for residue ZN D 805

Chain	Residue
D	GLU452
D	HIS456
D	HOH1083

site_id	AE1
Number of Residues	2
Details	binding site for residue ACT D 806

Chain	Residue
D	ARG713
D	LYS720

site_id	AE2
Number of Residues	5
Details	binding site for residue ACT D 807

Chain	Residue
D	LYS430
D	HIS433
D	GLU440
D	ZN804
D	HOH908

site_id	AE3
Number of Residues	4
Details	binding site for residue ZN D 808

Chain	Residue
D	GLU699
D	HOH1078
E	GLU452
E	HIS456

site_id	AE4
Number of Residues	11
Details	binding site for residue 9C6 E 1001

Chain	Residue
E	ILE502
E	PRO515
E	PHE516
E	SER750
E	LYS751
E	GLY752
F	LYS514
F	PRO515
F	SER750
F	LYS751
F	ASN775

site_id	AE5
Number of Residues	14
Details	binding site for residue GLU E 1002

Chain	Residue
E	TYR471
E	PRO499
E	LEU500
E	THR501
E	ARG506
E	LEU671
E	GLY674
E	SER675
E	THR676
E	GLU726
E	TYR753
E	HOH1106
E	HOH1142
E	HOH1154

site_id	AE6
Number of Residues	2
Details	binding site for residue ZN E 1003

Chain	Residue
E	HIS433
E	ACT1004

site_id	AE7
Number of Residues	3
Details	binding site for residue ACT E 1004

Chain	Residue
E	MET429
E	HIS433
E	ZN1003

site_id	AE8
Number of Residues	2
Details	binding site for residue ZN F 801

Chain	Residue
F	HIS433
F	ACT806

site_id	AE9
Number of Residues	13
Details	binding site for residue GLU F 802

Chain	Residue
F	TYR471
F	PRO499
F	LEU500
F	THR501
F	ARG506
F	GLY674
F	SER675
F	THR676
F	GLU726
F	TYR753
F	HOH907
F	HOH915
F	HOH917

site_id	AF1
Number of Residues	2
Details	binding site for residue ZN F 803

Chain	Residue
F	GLU452
F	HIS456

site_id	AF2
Number of Residues	2
Details	binding site for residue ZN F 804

Chain	Residue
F	ASP475
F	ACT805

site_id	AF3
Number of Residues	4
Details	binding site for residue ACT F 805

Chain	Residue
F	ASP475
F	ASP477
F	THR478
F	ZN804

site_id	AF4
Number of Residues	3
Details	binding site for residue ACT F 806

Chain	Residue
F	HIS433
F	GLU434
F	ZN801

site_id	AF5
Number of Residues	5
Details	binding site for residue ACT F 807

Chain	Residue
F	ALA473
F	ARG474
F	ASP475
F	ASN482
F	SER673

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:20614889, ECO:0007744\|PDB:2XHD

Chain	Residue	Details
A	PRO499
C	THR501
C	SER675
C	THR676
D	PRO499
D	THR501
D	SER675
D	THR676
E	PRO499
E	THR501
E	SER675
A	THR501
E	THR676
F	PRO499
F	THR501
F	SER675
F	THR676
A	SER675
A	THR676
B	PRO499
B	THR501
B	SER675
B	THR676
C	PRO499

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:20614889, ECO:0000269\|PubMed:21531559, ECO:0007744\|PDB:2XHD, ECO:0007744\|PDB:3R7X

Chain	Residue	Details
A	ARG506
B	ARG506
C	ARG506
D	ARG506
E	ARG506
F	ARG506

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:20614889, ECO:0000269\|PubMed:21531559, ECO:0007744\|PDB:2XHD

Chain	Residue	Details
A	GLU726
B	GLU726
C	GLU726
D	GLU726
E	GLU726
F	GLU726

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000250\|UniProtKB:P19491

Chain	Residue	Details
A	SER683
B	SER683
C	SER683
D	SER683
E	SER683
F	SER683

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000250\|UniProtKB:P19491

Chain	Residue	Details
A	SER717
B	SER717
C	SER717
D	SER717
E	SER717
F	SER717

site_id	SWS_FT_FI6
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN413
B	ASN413
C	ASN413
D	ASN413
E	ASN413
F	ASN413

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)