3R7X

Crystal Structure Analysis of a Quinazolinedione sulfonamide bound to human GluR2: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity

Summary for 3R7X

• Entry DOI: 10.2210/pdb3r7x/pdb
• Related: 2CMO
• Descriptor: Glutamate receptor 2, N-[6-(1H-imidazol-1-yl)-7-nitro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]methanesulfonamide, GLUTAMIC ACID, ... (4 entities in total)
• Functional Keywords: ion channel, ionic channel, postsynaptic membrane, transmembrane, transport protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane ; Multi-pass membrane protein : P42262
• Total number of polymer chains: 2
• Total formula weight: 59209.17

Authors

Kallen, J. (deposition date: 2011-03-23, release date: 2011-05-18, Last modification date: 2017-07-26)

• Primary citation: Koller, M.,Lingenhoehl, K.,Schmutz, M.,Vranesic, I.T.,Kallen, J.,Auberson, Y.P.,Carcache, D.A.,Mattes, H.,Ofner, S.,Orain, D.,Urwyler, S.; Quinazolinedione sulfonamides: A novel class of competitive AMPA receptor antagonists with oral activity.; Bioorg.Med.Chem.Lett., 21:3358-3361, 2011; PubMed: 21531559; DOI: 10.1016/j.bmcl.2011.04.017

Experimental method

X-RAY DIFFRACTION (2.1 Å)