3R7X

Crystal Structure Analysis of a Quinazolinedione sulfonamide bound to human GluR2: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE QSN A 264

Chain	Residue
A	GLU13
A	HOH278
A	HOH349
A	HOH458
A	TYR16
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	THR174
A	TYR220

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site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GLU B 264

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193
B	TYR220
B	HOH294
B	HOH315

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:20614889, ECO:0000269|PubMed:21531559

Chain	Residue	Details
A	TYR61
A	ARG96
A	GLU193
B	TYR61
B	ARG96
B	GLU193

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	PRO89
A	SER142
B	PRO89
B	SER142

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:P19491

Chain	Residue	Details
A	SER150
B	SER150

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000250|UniProtKB:P19491

Chain	Residue	Details
A	SER184
B	SER184

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3

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