3R7X
Crystal Structure Analysis of a Quinazolinedione sulfonamide bound to human GluR2: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glutamate receptor 2 | polymer | 263 | 29347.9 | 2 | UniProt (P42262) Pfam (PF10613) Pfam (PF00060) | Homo sapiens (human) | GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2 |
| 2 | C (A) | N-[6-(1H-imidazol-1-yl)-7-nitro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]methanesulfonamide | non-polymer | 366.3 | 1 | Chemie (QSN) | |||
| 3 | D (B) | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 446 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 117 (UniProt: P42262)
A, B: 120 - 263 (UniProt: P42262)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | cloning artifact |
| Pro 2 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Gly 118 | - | linker |
| Thr 119 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58695.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 513.4 | |
| All* | Total formula weight | 59209.2 |
