5ZG3

Crystal structure of the GluA2o LBD in complex with glutamate and TAK-137

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Glutamate receptor 2	polymer	263	29337.8	6	UniProt (P42262) Pfam (PF10613) Pfam (PF00060) In PDB	Homo sapiens (Human)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	E, A, D	9-(4-phenoxyphenyl)-3,4-dihydro-2H-2lambda~6~-pyrido[2,1-c][1,2,4]thiadiazine-2,2-dione	non-polymer		352.4	3	Chemie (9C6)
3	E, F, A, B, C...	GLUTAMIC ACID	non-polymer		147.1	6	Chemie (GLU)
4	D, E, F, B, C	ZINC ION	non-polymer		65.4	12	Chemie (ZN)
5	E, F, B, C, D	ACETATE ION	non-polymer		59.0	11	Chemie (ACT)
6		water	water		18.0	1062	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 413 - 527 (UniProt: P42262)

PDB	External Database	Details
Gly 411	-	expression tag
Ser 412	-	expression tag

A, B, C, D, E, F: 653 - 796 (UniProt: P42262)

PDB	External Database	Details
Gly 641	-	linker
Thr 642	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	176027.0
Non-Polymers*	Number of molecules	32
	Total formula weight	3374.4
All*	Total formula weight	179401.4

*Water molecules are not included.