5Y3M

Crystal structure of bovine TLR9 in complex with two DNAs (CpG DNA and TCGTTT DNA)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002224	biological_process	toll-like receptor signaling pathway
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane
B	0002224	biological_process	toll-like receptor signaling pathway
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0006955	biological_process	immune response
B	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00041
Number of Residues	45
Details	HTH_ARAC_FAMILY_1 Bacterial regulatory proteins, araC family signature. QLkaLSngSlppgirlqkLdVSSNSiGFvipg.FfvrATRliElNL

Chain	Residue	Details
A	GLN686-LEU730

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1580
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	GLU25-ASP815
B	GLU25-ASP815

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:25686612, ECO:0007744|PDB:3WPE

Chain	Residue	Details
A	TRP46
A	SER71
A	LYS94
B	TRP46
B	SER71
B	LYS94

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site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q2EEY0

Chain	Residue	Details
A	TYR131
A	TYR178
A	TYR207
A	ARG261
B	TYR131
B	TYR178
B	TYR207
B	ARG261

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site_id	SWS_FT_FI4
Number of Residues	4
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q9NR96

Chain	Residue	Details
A	CYS257
A	CYS264
B	CYS257
B	CYS264

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site_id	SWS_FT_FI5
Number of Residues	26
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN63
A	ASN565
A	ASN667
A	ASN692
A	ASN729
B	ASN63
B	ASN128
B	ASN199
B	ASN209
B	ASN241
B	ASN339
A	ASN128
B	ASN380
B	ASN472
B	ASN511
B	ASN565
B	ASN667
B	ASN692
B	ASN729
A	ASN199
A	ASN209
A	ASN241
A	ASN339
A	ASN380
A	ASN472
A	ASN511

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