5WLB

KRas G12V, bound to GppNHp and miniprotein 225-15a/b

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
D	0007165	biological_process	signal transduction
D	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue GNP A 201

Chain	Residue
A	VAL12
A	GLY60
A	ASN116
A	LYS117
A	ASP119
A	SER145
A	ALA146
A	LYS147
A	MG202
A	HOH404
A	HOH411
A	GLY13
A	HOH427
A	HOH441
B	HOH109
A	VAL14
A	GLY15
A	LYS16
A	SER17
A	ALA18
A	PHE28
A	ASP30

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 202

Chain	Residue
A	SER17
A	GNP201
A	HOH404
A	HOH427
B	HOH109

---

site_id	AC3
Number of Residues	8
Details	binding site for residue PG4 A 203

Chain	Residue
A	ASP69
A	GLN99
A	ARG102
A	VAL103
D	ASP69
D	GLN99
D	ARG102
D	VAL103

---

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 C 101

Chain	Residue
C	PRO2
C	ARG3
C	HOH207

---

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 C 102

Chain	Residue
C	ARG6
C	ARG23

---

site_id	AC6
Number of Residues	26
Details	binding site for residue GNP D 201

Chain	Residue
D	VAL12
D	GLY13
D	VAL14
D	GLY15
D	LYS16
D	SER17
D	ALA18
D	PHE28
D	GLY60
D	ASN116
D	LYS117
D	ASP119
D	LEU120
D	SER145
D	ALA146
D	LYS147
D	MG202
D	HOH308
D	HOH309
D	HOH316
D	HOH317
D	HOH325
D	HOH330
D	HOH333
D	HOH335
E	HOH112

---

site_id	AC7
Number of Residues	5
Details	binding site for residue MG D 202

Chain	Residue
D	SER17
D	GNP201
D	HOH309
D	HOH325
E	HOH112

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---