5TVP

SUMO2 bound to Mouse Tdp2 catalytic domain with a 5'-phosphorylated DNA ternary complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
B	0003824	molecular_function	catalytic activity
E	0003824	molecular_function	catalytic activity
G	0003824	molecular_function	catalytic activity
I	0003824	molecular_function	catalytic activity
K	0003824	molecular_function	catalytic activity
M	0003824	molecular_function	catalytic activity
O	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue PO4 I 401

Chain	Residue
I	LEU275
I	ARG276
I	ASP277
I	HIS323
I	ARG324
I	ARG327
I	HOH544

---

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO I 402

Chain	Residue
I	LYS349
I	HOH518
M	ALA311
M	HOH513
I	LEU347
I	GLU348

---

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO I 403

Chain	Residue
I	CYS149
I	TYR153
I	VAL345
I	GLY346
I	LEU347
I	GLU348
I	HOH514

---

site_id	AC4
Number of Residues	6
Details	binding site for residue PO4 O 401

Chain	Residue
O	LEU275
O	ARG276
O	ASP277
O	HIS323
O	ARG324
O	ARG327

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO O 402

Chain	Residue
O	GLU348
O	LYS349
O	HOH526

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO O 403

Chain	Residue
O	LEU139
O	PRO140
O	PRO166
O	TYR167
O	TYR170

---

site_id	AC7
Number of Residues	1
Details	binding site for residue EDO O 404

Chain	Residue
O	ASP343

---

site_id	AC8
Number of Residues	9
Details	binding site for residue PO4 E 401

Chain	Residue
E	LEU275
E	ASP277
E	HIS323
E	ARG324
E	ARG327
E	PO4403
E	HOH519
E	HOH535
E	HOH541

---

site_id	AC9
Number of Residues	6
Details	binding site for residue PO4 E 403

Chain	Residue
E	ASP277
E	ARG324
E	ARG327
E	PO4401
E	HOH519
E	HOH559

---

site_id	AD1
Number of Residues	6
Details	binding site for residue PO4 G 401

Chain	Residue
G	LEU275
G	ARG276
G	ASP277
G	HIS323
G	ARG324
G	ARG327

---

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO G 402

Chain	Residue
G	LEU347
G	GLU348
G	LYS349

---

site_id	AD3
Number of Residues	3
Details	binding site for residue EDO G 403

Chain	Residue
G	ILE180
G	THR182
G	GLN204

---

site_id	AD4
Number of Residues	2
Details	binding site for residue EDO G 404

Chain	Residue
G	PHE201
G	HOH533

---

site_id	AD5
Number of Residues	2
Details	binding site for residue EDO G 405

Chain	Residue
G	LYS252
G	CYS283

---

site_id	AD6
Number of Residues	6
Details	binding site for residue PO4 B 401

Chain	Residue
B	LEU275
B	ARG276
B	ASP277
B	HIS323
B	ARG324
B	ARG327

---

site_id	AD7
Number of Residues	5
Details	binding site for residue EDO B 402

Chain	Residue
B	LEU139
B	PRO140
B	TYR167
B	TYR170
B	HOH537

---

site_id	AD8
Number of Residues	7
Details	binding site for residue PO4 A 401

Chain	Residue
A	LEU275
A	ASP277
A	HIS323
A	ARG324
A	ARG327
A	HOH504
A	HOH514

---

site_id	AD9
Number of Residues	4
Details	binding site for residue EDO A 402

Chain	Residue
A	LEU347
A	GLU348
A	LYS349
A	HOH529

---

site_id	AE1
Number of Residues	6
Details	binding site for residue PO4 K 401

Chain	Residue
K	LEU275
K	ARG276
K	ASP277
K	HIS323
K	ARG324
K	ARG327

---

site_id	AE2
Number of Residues	5
Details	binding site for residue EDO K 402

Chain	Residue
E	HOH507
K	LEU347
K	GLU348
K	LYS349
K	HOH535

---

site_id	AE3
Number of Residues	3
Details	binding site for residue EDO K 403

Chain	Residue
K	LEU139
K	PRO166
K	HOH543

---

site_id	AE4
Number of Residues	7
Details	binding site for residue PO4 M 401

Chain	Residue
M	LEU275
M	ARG276
M	ASP277
M	HIS323
M	ARG324
M	ARG327
M	HOH530

---

site_id	AE5
Number of Residues	1
Details	binding site for residue CL M 402

Chain	Residue
M	LYS349

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:23806337

Chain	Residue	Details
Q	LYS11
O	ASP272
E	ASP272
G	ASP272
B	ASP272
A	ASP272
K	ASP272
M	ASP272

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P61956

Chain	Residue	Details
Q	LYS11
O	ASP132
E	ASP132
G	ASP132
B	ASP132
A	ASP132
K	ASP132
M	ASP132

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:P61956

Chain	Residue	Details
I	GLU162
Q	LYS21
E	GLU162
G	GLU162
B	GLU162
A	GLU162
K	GLU162
M	GLU162

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	SITE: Interaction with 5' end of substrate DNA => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:27060144

Chain	Residue	Details
I	TYR188
O	TYR188
E	TYR188
G	TYR188
B	TYR188
A	TYR188
K	TYR188
M	TYR188

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	SITE: Interaction with 5' end of substrate DNA => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:24808172, ECO:0000269|PubMed:27060144

Chain	Residue	Details
I	TRP307
B	HIS359
A	TRP307
A	HIS359
K	TRP307
K	HIS359
M	TRP307
M	HIS359
I	HIS359
O	TRP307
O	HIS359
E	TRP307
E	HIS359
G	TRP307
G	HIS359
B	TRP307

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	SITE: Interaction with 5' end of substrate DNA => ECO:0000269|PubMed:23104055

Chain	Residue	Details
I	PHE325
O	PHE325
E	PHE325
G	PHE325
B	PHE325
A	PHE325
K	PHE325
M	PHE325

---