5SVS
Anomalous Mn2+ signal reveals a divalent cation-binding site in the head domain of the ATP-gated human P2X3 ion channel
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001614 | molecular_function | purinergic nucleotide receptor activity |
| A | 0001666 | biological_process | response to hypoxia |
| A | 0004931 | molecular_function | extracellularly ATP-gated monoatomic cation channel activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0007165 | biological_process | signal transduction |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0007274 | biological_process | neuromuscular synaptic transmission |
| A | 0009266 | biological_process | response to temperature stimulus |
| A | 0009408 | biological_process | response to heat |
| A | 0009409 | biological_process | response to cold |
| A | 0009612 | biological_process | response to mechanical stimulus |
| A | 0009743 | biological_process | response to carbohydrate |
| A | 0010524 | biological_process | positive regulation of calcium ion transport into cytosol |
| A | 0014832 | biological_process | urinary bladder smooth muscle contraction |
| A | 0015267 | molecular_function | channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0030424 | cellular_component | axon |
| A | 0030432 | biological_process | peristalsis |
| A | 0033198 | biological_process | response to ATP |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0035590 | biological_process | purinergic nucleotide receptor signaling pathway |
| A | 0043005 | cellular_component | neuron projection |
| A | 0043235 | cellular_component | receptor complex |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048167 | biological_process | regulation of synaptic plasticity |
| A | 0048266 | biological_process | behavioral response to pain |
| A | 0050804 | biological_process | modulation of chemical synaptic transmission |
| A | 0050850 | biological_process | positive regulation of calcium-mediated signaling |
| A | 0050909 | biological_process | sensory perception of taste |
| A | 0051649 | biological_process | establishment of localization in cell |
| A | 0060079 | biological_process | excitatory postsynaptic potential |
| A | 0070207 | biological_process | protein homotrimerization |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0071318 | biological_process | cellular response to ATP |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 0098662 | biological_process | inorganic cation transmembrane transport |
| A | 0098685 | cellular_component | Schaffer collateral - CA1 synapse |
| A | 0098686 | cellular_component | hippocampal mossy fiber to CA3 synapse |
| A | 0098794 | cellular_component | postsynapse |
Functional Information from PROSITE/UniProt
| site_id | PS01212 |
| Number of Residues | 27 |
| Details | P2X_RECEPTOR ATP P2X receptors signature. GGvLGIkIgWvCDLDkawdqCiPkYsF |
| Chain | Residue | Details |
| A | GLY236-PHE262 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:27626375 |
| Chain | Residue | Details |
| A | TRP21-PHE43 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 278 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:27626375 |
| Chain | Residue | Details |
| A | LEU44-ILE322 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:27626375 |
| Chain | Residue | Details |
| A | ILE323-ILE341 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0007744|PDB:6AH5 |
| Chain | Residue | Details |
| A | LYS63 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:6AH4, ECO:0007744|PDB:6AH5 |
| Chain | Residue | Details |
| A | LYS65 | |
| A | THR172 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29674445, ECO:0007744|PDB:5YVE |
| Chain | Residue | Details |
| A | GLU111 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29674445, ECO:0000269|PubMed:31232692, ECO:0007744|PDB:5SVS, ECO:0007744|PDB:5YVE, ECO:0007744|PDB:6AH5 |
| Chain | Residue | Details |
| A | ASP158 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP, ECO:0007744|PDB:6AH4, ECO:0007744|PDB:6AH5 |
| Chain | Residue | Details |
| A | SER275 | |
| A | ASN279 | |
| A | LYS299 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP, ECO:0007744|PDB:6AH4, ECO:0007744|PDB:6AH5 |
| Chain | Residue | Details |
| A | ARG281 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK |
| Chain | Residue | Details |
| A | ASN139 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27626375, ECO:0000269|PubMed:29674445, ECO:0000269|PubMed:31232692, ECO:0007744|PDB:5SVJ, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP, ECO:0007744|PDB:5SVQ, ECO:0007744|PDB:5SVR, ECO:0007744|PDB:5SVS, ECO:0007744|PDB:5SVT, ECO:0007744|PDB:5YVE, ECO:0007744|PDB:6AH4, ECO:0007744|PDB:6AH5 |
| Chain | Residue | Details |
| A | ASN170 | |
| A | ASN290 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27626375, ECO:0000269|PubMed:31232692, ECO:0007744|PDB:5SVJ, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP, ECO:0007744|PDB:5SVQ, ECO:0007744|PDB:5SVS, ECO:0007744|PDB:5SVT, ECO:0007744|PDB:6AH4, ECO:0007744|PDB:6AH5 |
| Chain | Residue | Details |
| A | ASN194 |
