5SVS

Anomalous Mn2+ signal reveals a divalent cation-binding site in the head domain of the ATP-gated human P2X3 ion channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001614	molecular_function	purinergic nucleotide receptor activity
A	0001666	biological_process	response to hypoxia
A	0004931	molecular_function	extracellularly ATP-gated monoatomic cation channel activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0007165	biological_process	signal transduction
A	0007268	biological_process	chemical synaptic transmission
A	0007274	biological_process	neuromuscular synaptic transmission
A	0009266	biological_process	response to temperature stimulus
A	0009408	biological_process	response to heat
A	0009409	biological_process	response to cold
A	0009612	biological_process	response to mechanical stimulus
A	0009743	biological_process	response to carbohydrate
A	0010524	biological_process	positive regulation of calcium ion transport into cytosol
A	0014832	biological_process	urinary bladder smooth muscle contraction
A	0016020	cellular_component	membrane
A	0030424	cellular_component	axon
A	0030432	biological_process	peristalsis
A	0033198	biological_process	response to ATP
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035590	biological_process	purinergic nucleotide receptor signaling pathway
A	0043005	cellular_component	neuron projection
A	0043235	cellular_component	receptor complex
A	0046872	molecular_function	metal ion binding
A	0048167	biological_process	regulation of synaptic plasticity
A	0048266	biological_process	behavioral response to pain
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0050850	biological_process	positive regulation of calcium-mediated signaling
A	0050909	biological_process	sensory perception of taste
A	0051649	biological_process	establishment of localization in cell
A	0060079	biological_process	excitatory postsynaptic potential
A	0070207	biological_process	protein homotrimerization
A	0070588	biological_process	calcium ion transmembrane transport
A	0071318	biological_process	cellular response to ATP
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0098662	biological_process	inorganic cation transmembrane transport
A	0098685	cellular_component	Schaffer collateral - CA1 synapse
A	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
A	0098794	cellular_component	postsynapse

Functional Information from PROSITE/UniProt

site_id	PS01212
Number of Residues	27
Details	P2X_RECEPTOR ATP P2X receptors signature. GGvLGIkIgWvCDLDkawdqCiPkYsF

Chain	Residue	Details
A	GLY236-PHE262

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29674445","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5YVE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29674445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31232692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29674445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31232692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31232692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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