5OMW
Mutant T252A of E. coli leucyl-tRNA synthetase, tRNA(leu) and leucyl-adenylate analogue in the aminoacylation conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002161 | molecular_function | aminoacyl-tRNA editing activity |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004823 | molecular_function | leucine-tRNA ligase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006429 | biological_process | leucyl-tRNA aminoacylation |
| A | 0106074 | biological_process | aminoacyl-tRNA metabolism involved in translational fidelity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0002161 | molecular_function | aminoacyl-tRNA editing activity |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004823 | molecular_function | leucine-tRNA ligase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006412 | biological_process | translation |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006429 | biological_process | leucyl-tRNA aminoacylation |
| D | 0106074 | biological_process | aminoacyl-tRNA metabolism involved in translational fidelity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 900 |
| Chain | Residue |
| A | CYS159 |
| A | CYS176 |
| A | THR181 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | binding site for residue LSS A 901 |
| Chain | Residue |
| A | HIS52 |
| A | ASN55 |
| A | TYR56 |
| A | ASP80 |
| A | SER496 |
| A | GLY529 |
| A | GLY530 |
| A | GLU532 |
| A | HIS533 |
| A | HIS537 |
| A | GLN566 |
| A | GLY567 |
| A | MET568 |
| A | VAL569 |
| A | MET620 |
| B | A76 |
| A | MET40 |
| A | LEU41 |
| A | PRO42 |
| A | TYR43 |
| A | HIS49 |
| A | GLY51 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 101 |
| Chain | Residue |
| B | U8 |
| B | G9 |
| B | G12 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue ZN D 900 |
| Chain | Residue |
| D | CYS159 |
| D | CYS176 |
| D | THR181 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | binding site for residue LSS D 901 |
| Chain | Residue |
| D | MET40 |
| D | LEU41 |
| D | PRO42 |
| D | TYR43 |
| D | HIS49 |
| D | GLY51 |
| D | HIS52 |
| D | ASN55 |
| D | TYR56 |
| D | ASP80 |
| D | GLY529 |
| D | GLY530 |
| D | GLU532 |
| D | HIS533 |
| D | HIS537 |
| D | GLN566 |
| D | GLY567 |
| D | MET568 |
| D | VAL569 |
| D | MET620 |
| E | A76 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue MG E 101 |
| Chain | Residue |
| E | U8 |
| E | G9 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 12 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PypSGrLHMGHV |
| Chain | Residue | Details |
| A | PRO42-VAL53 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00049 |
| Chain | Residue | Details |
| A | LYS622 | |
| D | LYS622 |
