5NG9
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist CIP-AS at 1.15 A resolution.
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue FLC A 301 |
| Chain | Residue |
| A | MET19 |
| A | HIS23 |
| A | ARG31 |
| A | FLC302 |
| A | HOH436 |
| A | HOH601 |
| A | HOH659 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue FLC A 302 |
| Chain | Residue |
| A | HOH401 |
| A | HOH411 |
| A | HOH482 |
| A | ARG31 |
| A | FLC301 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue LI A 303 |
| Chain | Residue |
| A | GLU97 |
| A | ILE100 |
| A | ASP101 |
| A | HOH459 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue 8VN A 304 |
| Chain | Residue |
| A | TYR61 |
| A | PRO89 |
| A | THR91 |
| A | ARG96 |
| A | LEU138 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | GLU193 |
| A | MET196 |
| A | 8WQ305 |
| A | HOH414 |
| A | HOH462 |
| A | HOH579 |
| A | HOH597 |
| A | HOH609 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue 8WQ A 305 |
| Chain | Residue |
| A | TYR61 |
| A | PRO89 |
| A | THR91 |
| A | ARG96 |
| A | LEU138 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | GLU193 |
| A | 8VN304 |
| A | HOH462 |
| A | HOH579 |
| A | HOH597 |
| A | HOH609 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 306 |
| Chain | Residue |
| A | LYS82 |
| A | LYS116 |
| A | HOH403 |
| A | HOH610 |
| A | HOH635 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 307 |
| Chain | Residue |
| A | ARG64 |
| A | LYS69 |
| A | HOH580 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 308 |
| Chain | Residue |
| A | ARG148 |
| A | ARG149 |
| A | HOH453 |
| A | HOH720 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 309 |
| Chain | Residue |
| A | LYS60 |
| A | SER140 |
| A | HOH406 |
| A | HOH444 |
| A | HOH455 |
| A | HOH477 |
| A | HOH614 |
| A | HOH650 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
