5NG9

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist CIP-AS at 1.15 A resolution.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue FLC A 301

Chain	Residue
A	MET19
A	HIS23
A	ARG31
A	FLC302
A	HOH436
A	HOH601
A	HOH659

---

site_id	AC2
Number of Residues	5
Details	binding site for residue FLC A 302

Chain	Residue
A	HOH401
A	HOH411
A	HOH482
A	ARG31
A	FLC301

---

site_id	AC3
Number of Residues	4
Details	binding site for residue LI A 303

Chain	Residue
A	GLU97
A	ILE100
A	ASP101
A	HOH459

---

site_id	AC4
Number of Residues	16
Details	binding site for residue 8VN A 304

Chain	Residue
A	TYR61
A	PRO89
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143
A	GLU193
A	MET196
A	8WQ305
A	HOH414
A	HOH462
A	HOH579
A	HOH597
A	HOH609

---

site_id	AC5
Number of Residues	14
Details	binding site for residue 8WQ A 305

Chain	Residue
A	TYR61
A	PRO89
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143
A	GLU193
A	8VN304
A	HOH462
A	HOH579
A	HOH597
A	HOH609

---

site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 A 306

Chain	Residue
A	LYS82
A	LYS116
A	HOH403
A	HOH610
A	HOH635

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 A 307

Chain	Residue
A	ARG64
A	LYS69
A	HOH580

---

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 A 308

Chain	Residue
A	ARG148
A	ARG149
A	HOH453
A	HOH720

---

site_id	AC9
Number of Residues	8
Details	binding site for residue GOL A 309

Chain	Residue
A	LYS60
A	SER140
A	HOH406
A	HOH444
A	HOH455
A	HOH477
A	HOH614
A	HOH650

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:16483599

Chain	Residue	Details
A	ARG96
A	GLU193
A	TYR61

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	PRO89

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	THR143
A	THR91
A	SER142

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3

---