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5LX5

CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782-RP.

Functional Information from GO Data
ChainGOidnamespacecontents
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0007165biological_processsignal transduction
A0007267biological_processcell-cell signaling
A0007623biological_processcircadian rhythm
A0008284biological_processpositive regulation of cell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0009435biological_processNAD biosynthetic process
A0016607cellular_componentnuclear speck
A0016757molecular_functionglycosyltransferase activity
A0019363biological_processpyridine nucleotide biosynthetic process
A0030054cellular_componentcell junction
A0032922biological_processcircadian regulation of gene expression
A0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
A0042802molecular_functionidentical protein binding
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0047280molecular_functionnicotinamide phosphoribosyltransferase activity
A0048511biological_processrhythmic process
A0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
A0060612biological_processadipose tissue development
A0070062cellular_componentextracellular exosome
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0007165biological_processsignal transduction
B0007267biological_processcell-cell signaling
B0007623biological_processcircadian rhythm
B0008284biological_processpositive regulation of cell population proliferation
B0008286biological_processinsulin receptor signaling pathway
B0009435biological_processNAD biosynthetic process
B0016607cellular_componentnuclear speck
B0016757molecular_functionglycosyltransferase activity
B0019363biological_processpyridine nucleotide biosynthetic process
B0030054cellular_componentcell junction
B0032922biological_processcircadian regulation of gene expression
B0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
B0042802molecular_functionidentical protein binding
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0047280molecular_functionnicotinamide phosphoribosyltransferase activity
B0048511biological_processrhythmic process
B0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
B0060612biological_processadipose tissue development
B0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues38
Detailsbinding site for residue 7A0 A 501
ChainResidue
ATYR188
ATHR304
AARG311
AARG349
AVAL350
AILE351
AGLY353
AILE378
AALA379
AGLY383
AGLY384
AHIS191
AHOH602
AHOH604
AHOH605
AHOH611
AHOH614
AHOH645
AHOH647
AHOH673
AHOH689
AHOH757
APHE193
AHOH769
AHOH831
AHOH909
AHOH952
BASP16
BTYR18
BARG392
BDPO502
BHOH607
AARG196
AASP219
ASER241
AVAL242
AALA244
ASER275

site_idAC2
Number of Residues15
Detailsbinding site for residue DPO A 502
ChainResidue
AARG40
AARG392
ASER398
ALYS400
ALYS415
ALYS423
AHOH601
AHOH603
AHOH606
AHOH620
AHOH655
AHOH709
AHOH801
BARG196
B7A0501

site_idAC3
Number of Residues35
Detailsbinding site for residue 7A0 B 501
ChainResidue
AASP16
ATYR18
AARG392
ADPO502
AHOH655
BTYR188
BHIS191
BPHE193
BARG196
BASP219
BSER241
BVAL242
BALA244
BSER275
BTHR304
BARG311
BARG349
BVAL350
BILE351
BGLY353
BALA379
BGLY383
BGLY384
BHOH601
BHOH602
BHOH603
BHOH634
BHOH650
BHOH677
BHOH683
BHOH740
BHOH767
BHOH768
BHOH806
BHOH829

site_idAC4
Number of Residues13
Detailsbinding site for residue DPO B 502
ChainResidue
BHOH832
BHOH887
AARG196
A7A0501
BARG40
BARG392
BSER398
BLYS400
BLYS415
BLYS423
BHOH604
BHOH607
BHOH674

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBINDING:
ChainResidueDetails
AARG196
BHIS247
BARG311
BGLY353
BGLY384
BARG392
AASP219
AHIS247
AARG311
AGLY353
AGLY384
AARG392
BARG196
BASP219

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895
ChainResidueDetails
AMET1
BMET1

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ATYR188
BTYR188

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER472
BSER472

226707

PDB entries from 2024-10-30

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