5LUZ

Structure of Human Neurolysin (E475Q) in complex with neurotensin peptide products

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006111	biological_process	regulation of gluconeogenesis
A	0006508	biological_process	proteolysis
A	0006518	biological_process	peptide metabolic process
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0016787	molecular_function	hydrolase activity
A	0042277	molecular_function	peptide binding
A	0046872	molecular_function	metal ion binding
A	1902809	biological_process	regulation of skeletal muscle fiber differentiation
B	0004222	molecular_function	metalloendopeptidase activity
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006111	biological_process	regulation of gluconeogenesis
B	0006508	biological_process	proteolysis
B	0006518	biological_process	peptide metabolic process
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0008233	molecular_function	peptidase activity
B	0008237	molecular_function	metallopeptidase activity
B	0016787	molecular_function	hydrolase activity
B	0042277	molecular_function	peptide binding
B	0046872	molecular_function	metal ion binding
B	1902809	biological_process	regulation of skeletal muscle fiber differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	HIS474
A	HIS478
A	GLU503
C	PRO10

---

site_id	AC2
Number of Residues	1
Details	binding site for residue CL A 1002

Chain	Residue
A	ASN163

---

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 1003

Chain	Residue
A	GLU73
A	ILE77
A	ASN496

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 1001

Chain	Residue
B	HIS478
B	GLU503
D	PRO9
B	HIS474

---

site_id	AC5
Number of Residues	1
Details	binding site for residue CL B 1002

Chain	Residue
B	ASN163

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---