5L2X
Crystal structure of human PrimPol ternary complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| A | 0006269 | biological_process | DNA replication, synthesis of primer |
| A | 0042276 | biological_process | error-prone translesion synthesis |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| B | 0006269 | biological_process | DNA replication, synthesis of primer |
| B | 0042276 | biological_process | error-prone translesion synthesis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue DTP A 401 |
| Chain | Residue |
| A | ARG76 |
| A | ARG291 |
| A | LYS297 |
| A | CA402 |
| A | HOH519 |
| A | HOH530 |
| C | DT3 |
| D | DDG14 |
| A | TYR100 |
| A | ASP114 |
| A | GLU116 |
| A | LYS165 |
| A | SER167 |
| A | HIS169 |
| A | ARG288 |
| A | ASN289 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 402 |
| Chain | Residue |
| A | ASP114 |
| A | GLU116 |
| A | DTP401 |
| A | HOH514 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue DTP B 401 |
| Chain | Residue |
| B | ARG76 |
| B | TYR100 |
| B | ASP114 |
| B | GLU116 |
| B | LYS165 |
| B | SER167 |
| B | HIS169 |
| B | ARG288 |
| B | ASN289 |
| B | ARG291 |
| B | LYS297 |
| B | CA402 |
| B | HOH537 |
| B | HOH544 |
| G | DT3 |
| H | DDG14 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 402 |
| Chain | Residue |
| B | ASP114 |
| B | GLU116 |
| B | DTP401 |
| B | HOH503 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for Di-nucleotide DC G 6 and 5IU G 7 |
| Chain | Residue |
| G | DG5 |
| G | DA8 |
| H | DT10 |
| H | DA11 |
| H | DG12 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for Di-nucleotide 5IU G 7 and DA G 8 |
| Chain | Residue |
| G | DC6 |
| G | DC9 |
| H | DG9 |
| H | DT10 |
| H | DA11 |
| H | DG12 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for Di-nucleotide DC H 13 and DDG H 14 |
| Chain | Residue |
| B | ASP280 |
| B | ARG288 |
| B | DTP401 |
| G | DC4 |
| G | DG5 |
| H | DG12 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27819052","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L2X","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24126761","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27819052","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5L2X","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27819052","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5L2X","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
