5K25

Crystal structure of human phosphatase PRL-2 in complex with the ADP-bound Bateman domain of human magnesium transporter CNNM3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0004727	molecular_function	prenylated protein tyrosine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005769	cellular_component	early endosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation
C	0010960	biological_process	magnesium ion homeostasis

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue ADP C 501

Chain	Residue
C	THR319
C	HIS412
C	LEU434
C	THR436
C	GLU438
C	ASP439
C	ASP323
C	CYS324
C	PHE325
C	GLY345
C	HIS346
C	THR347
C	ARG348
C	PRO350

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250

Chain	Residue	Details
A	ASP69

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160

Chain	Residue	Details
A	CYS101

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	VAL102
A	ARG107

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Cysteine methyl ester => ECO:0000305

Chain	Residue	Details
A	CYS164

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site_id	SWS_FT_FI5
Number of Residues	1
Details	LIPID: S-farnesyl cysteine => ECO:0000269|PubMed:11447212, ECO:0000269|PubMed:9018080

Chain	Residue	Details
A	CYS164

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