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5JK7

The X-ray structure of the DDB1-DCAF1-Vpr-UNG2 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000781cellular_componentchromosome, telomeric region
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0006281biological_processDNA repair
A0006289biological_processnucleotide-excision repair
A0006511biological_processubiquitin-dependent protein catabolic process
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007056biological_processspindle assembly involved in female meiosis
A0010498biological_processproteasomal protein catabolic process
A0016055biological_processWnt signaling pathway
A0016567biological_processprotein ubiquitination
A0019076biological_processviral release from host cell
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
A0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
A0032991cellular_componentprotein-containing complex
A0034644biological_processcellular response to UV
A0035234biological_processectopic germ cell programmed cell death
A0035861cellular_componentsite of double-strand break
A0042752biological_processregulation of circadian rhythm
A0043066biological_processnegative regulation of apoptotic process
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0044725biological_processepigenetic programming in the zygotic pronuclei
A0044877molecular_functionprotein-containing complex binding
A0045070biological_processpositive regulation of viral genome replication
A0045722biological_processpositive regulation of gluconeogenesis
A0045732biological_processpositive regulation of protein catabolic process
A0046726biological_processpositive regulation by virus of viral protein levels in host cell
A0048511biological_processrhythmic process
A0051093biological_processnegative regulation of developmental process
A0051702biological_processbiological process involved in interaction with symbiont
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060337biological_processtype I interferon-mediated signaling pathway
A0070062cellular_componentextracellular exosome
A0070914biological_processUV-damage excision repair
A0071987molecular_functionWD40-repeat domain binding
A0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
A0097510biological_processbase-excision repair, AP site formation via deaminated base removal
A0097602molecular_functioncullin family protein binding
A0160072molecular_functionubiquitin ligase complex scaffold activity
A1901990biological_processregulation of mitotic cell cycle phase transition
A2000242biological_processnegative regulation of reproductive process
B0000781cellular_componentchromosome, telomeric region
B0003676molecular_functionnucleic acid binding
B0003677molecular_functionDNA binding
B0003684molecular_functiondamaged DNA binding
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0006281biological_processDNA repair
B0006289biological_processnucleotide-excision repair
B0006511biological_processubiquitin-dependent protein catabolic process
B0006915biological_processapoptotic process
B0006974biological_processDNA damage response
B0007056biological_processspindle assembly involved in female meiosis
B0010498biological_processproteasomal protein catabolic process
B0016055biological_processWnt signaling pathway
B0016567biological_processprotein ubiquitination
B0019076biological_processviral release from host cell
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
B0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
B0032991cellular_componentprotein-containing complex
B0034644biological_processcellular response to UV
B0035234biological_processectopic germ cell programmed cell death
B0035861cellular_componentsite of double-strand break
B0042752biological_processregulation of circadian rhythm
B0043066biological_processnegative regulation of apoptotic process
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0044725biological_processepigenetic programming in the zygotic pronuclei
B0044877molecular_functionprotein-containing complex binding
B0045070biological_processpositive regulation of viral genome replication
B0045722biological_processpositive regulation of gluconeogenesis
B0045732biological_processpositive regulation of protein catabolic process
B0046726biological_processpositive regulation by virus of viral protein levels in host cell
B0048511biological_processrhythmic process
B0051093biological_processnegative regulation of developmental process
B0051702biological_processbiological process involved in interaction with symbiont
B0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0060337biological_processtype I interferon-mediated signaling pathway
B0070062cellular_componentextracellular exosome
B0070914biological_processUV-damage excision repair
B0071987molecular_functionWD40-repeat domain binding
B0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
B0097510biological_processbase-excision repair, AP site formation via deaminated base removal
B0097602molecular_functioncullin family protein binding
B0160072molecular_functionubiquitin ligase complex scaffold activity
B1901990biological_processregulation of mitotic cell cycle phase transition
B2000242biological_processnegative regulation of reproductive process
C0016567biological_processprotein ubiquitination
D0004844molecular_functionuracil DNA N-glycosylase activity
D0006281biological_processDNA repair
D0006284biological_processbase-excision repair
D0016799molecular_functionhydrolase activity, hydrolyzing N-glycosyl compounds
E0016567biological_processprotein ubiquitination
F0005515molecular_functionprotein binding
F0006351biological_processDNA-templated transcription
F0006355biological_processregulation of DNA-templated transcription
F0006811biological_processmonoatomic ion transport
F0019058biological_processviral life cycle
F0034220biological_processmonoatomic ion transmembrane transport
F0039592biological_processsymbiont-mediated arrest of host cell cycle during G2/M transition
F0042025cellular_componenthost cell nucleus
F0043655cellular_componenthost extracellular space
F0043657cellular_componenthost cell
F0044071biological_processsymbiont-mediated perturbation of host cell cycle progression
F0044423cellular_componentvirion component
F0046718biological_processsymbiont entry into host cell
F0051260biological_processprotein homooligomerization
F0051701biological_processbiological process involved in interaction with host
F0052151biological_processsymbiont-mediated activation of host apoptosis
F0075732biological_processviral penetration into host nucleus
G0004844molecular_functionuracil DNA N-glycosylase activity
G0006281biological_processDNA repair
G0006284biological_processbase-excision repair
G0016799molecular_functionhydrolase activity, hydrolyzing N-glycosyl compounds
H0005515molecular_functionprotein binding
H0006351biological_processDNA-templated transcription
H0006355biological_processregulation of DNA-templated transcription
H0006811biological_processmonoatomic ion transport
H0019058biological_processviral life cycle
H0034220biological_processmonoatomic ion transmembrane transport
H0039592biological_processsymbiont-mediated arrest of host cell cycle during G2/M transition
H0042025cellular_componenthost cell nucleus
H0043655cellular_componenthost extracellular space
H0043657cellular_componenthost cell
H0044071biological_processsymbiont-mediated perturbation of host cell cycle progression
H0044423cellular_componentvirion component
H0046718biological_processsymbiont entry into host cell
H0051260biological_processprotein homooligomerization
H0051701biological_processbiological process involved in interaction with host
H0052151biological_processsymbiont-mediated activation of host apoptosis
H0075732biological_processviral penetration into host nucleus
Functional Information from PROSITE/UniProt
site_idPS00130
Number of Residues10
DetailsU_DNA_GLYCOSYLASE Uracil-DNA glycosylase signature. KVVIlGQDPY
ChainResidueDetails
DLYS138-TYR147

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsMOD_RES: Phosphoserine; by host => ECO:0000255|HAMAP-Rule:MF_04080
ChainResidueDetails
FSER79
FSER94
FSER96
HSER79
HSER94
HSER96

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:8900285, ECO:0000269|PubMed:9724657, ECO:0000312|PDB:1SSP, ECO:0000312|PDB:4SKN
ChainResidueDetails
DALA153
DPRO167
DGLN213
DGLY277
GALA153
GPRO167
GGLN213
GGLY277

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:8900285, ECO:0000312|PDB:4SKN
ChainResidueDetails
DCYS157
GPHE279
GARG282
GSER285
DSER178
DILE256
DPHE279
DARG282
DSER285
GCYS157
GSER178
GILE256

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Essential for UNG2 recruitment to nuclear foci => ECO:0000269|PubMed:22521144
ChainResidueDetails
DSER88
GSER88
BLYS1121

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
DGLY295
GGLY295

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PDB entries from 2025-06-11

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