5JIX

PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-Br-cGMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004692	molecular_function	cGMP-dependent protein kinase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue CA A 501

Chain	Residue
A	THR348
A	HOH617
A	HOH629
A	HOH639
A	HOH665
A	HOH700
A	HOH712

---

site_id	AC2
Number of Residues	1
Details	binding site for residue CA A 502

Chain	Residue
A	HOH718

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 503

Chain	Residue
A	HOH607
A	HOH611
A	HOH682
A	HOH686
A	HOH711
A	HOH605

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CA A 504

Chain	Residue
A	GLU395
A	GLN398
A	EDO508
A	HOH636
A	HOH657
A	HOH667

---

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO A 505

Chain	Residue
A	TYR312
A	ILE313
A	GLU318
A	GLU395
A	NA512
A	HOH606

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 506

Chain	Residue
A	LYS297
A	ASP383
A	GLU385
A	THR386
A	HOH613

---

site_id	AC7
Number of Residues	6
Details	binding site for residue EDO A 507

Chain	Residue
A	ILE314
A	GLU319
A	GLY320
A	ARG366
A	HOH609
A	HOH626

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO A 508

Chain	Residue
A	ASP308
A	ASP311
A	GLY392
A	THR393
A	GLN398
A	CA504
A	HOH667

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO A 509

Chain	Residue
A	GLU353
A	TYR354
A	TYR404
A	HOH685
A	HOH687

---

site_id	AD1
Number of Residues	9
Details	binding site for residue PE5 A 510

Chain	Residue
A	ASN289
A	LYS332
A	LEU345
A	GLU373
A	PHE394
A	GLU396
A	LEU397
A	HOH608
A	HOH653

---

site_id	AD2
Number of Residues	16
Details	binding site for residue 6J7 A 511

Chain	Residue
A	GLN335
A	LYS347
A	PHE355
A	GLY356
A	GLU357
A	LYS358
A	ALA359
A	ARG366
A	SER367
A	ALA368
A	ILE370
A	LEU408
A	ASP412
A	ARG415
A	HOH624
A	HOH643

---

site_id	AD3
Number of Residues	7
Details	binding site for residue NA A 512

Chain	Residue
A	GLU305
A	TYR307
A	ILE313
A	GLU395
A	LYS399
A	EDO505
A	HOH606

---

Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrEGEeGStFFILakG

Chain	Residue	Details
A	ILE313-GLY329

---

site_id	PS00889
Number of Residues	18
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEkALisddv......RSAnIiA

Chain	Residue	Details
A	PHE355-ALA372

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	130
Details	Region: {"description":"cGMP-binding, high affinity; cAMP-binding, low affinity","evidences":[{"source":"PubMed","id":"26769964","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26769964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BV6","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26769964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---