5JBT

Mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (APLP2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
Y	0004867	molecular_function	serine-type endopeptidase inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 301

Chain	Residue
A	GLU70
A	ASN72
A	VAL75
A	GLU77
A	GLU80
A	HOH463

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site_id	AC2
Number of Residues	9
Details	binding site for residue SO4 Y 101

Chain	Residue
X	PRO13
Y	ARG42
Y	ASN43
Y	ASN44
Y	HOH202
Y	HOH218
A	HIS217
A	GLY219
X	GLY12

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
A	VAL53-CYS58

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site_id	PS00280
Number of Residues	19
Details	BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FiyGGCggnrnnFesedyC

Chain	Residue	Details
Y	PHE33-CYS51

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27810896","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11827488","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25301953","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27810896","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1H4W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L3T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P92","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U30","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U32","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JBT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Required for specificity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Sulfotyrosine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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